Magnesium (Mg) alloys have attracted a wealth of attention in orthopedic fields for their superior mechanical properties, degradability, and excellent biocompatibility. Consistently, to resolve the issues on rapid degradation, more studies are dedicated researches composition design, preparation processing, surface modification, degradation modes Mg alloys. Nevertheless, mechanisms by which promote bone healing remain elusive. This review gives an account specific promoting from four...

It is of profound significance for clinical bone regeneration to clarify the specific molecular mechanism from which we found that osteogenic differentiation adipose-derived stem cells (ADSCs) will be probably promoted by exosomes.By means lentiviral transfection, miR-130a-3p overexpression and knockdown ADSCs were constructed. Alizarin Red S was used detect calcium deposits, qPCR osteogenesis-related genes, verify effect on ADSCs. CCK-8 proliferation The target binding between SIRT7...

Human adipose-derived stem cells (ADSCs) can release exosomes; however, their specific functions remain elusive. In this study, we verified that exosomes derived from osteogenically differentiated ADSCs promote osteogenic differentiation of ADSCs. Furthermore, in order to investigate the importance exosomal microRNAs (miRNAs) ADSCs, used microarray assays analyze expression profiles miRNAs undifferentiated as well ADSCs; 201 were upregulated and 33 downregulated between two types exosomes....

Abstract Background Human adipose-derived stem cells (hADSCs) are with the potential to differentiate in multiple directions. miR-204-5p is expressed at low levels during osteogenic differentiation of hADSCs, and its specific regulatory mechanism remains unclear. Here, we aimed explore function possible molecular hADSCs. Methods The expression patterns miR-204-5p, Runx2 , alkaline phosphatase ( ALP ), osteocalcin OCN forkhead box C1 FOXC1 ) growth factor 7 GDF7 hADSCs osteogenesis were...

Background and importance Leiomyosarcoma is a rare aggressive malignant tumor with high potential for relapse metastasis. Correct timely diagnosis critical effective treatment, yet it often challenging due to the diverse clinical presentations. This case report highlights significance of early identification consequences delayed in scalp leiomyosarcoma. Clinical presentation We present 39-year-old woman neoplasm. Initially, was missed, leading delay surgical intervention. The demonstrated...

Titanium and titanium alloys (Ti 6 Al 4 V Ti) have been widely used in bone tissue engineering to repair maxillofacial defects caused by traumas tumors. However, such materials are also bio-inert, which does not match the elastic modulus of bone. Therefore, different surface modifications proposed for clinical application. Based on use traditional alloy field defects, we prepared a compound Gr-Ti scaffold with ADSC-derived Exos. The results showed that scaffolds low toxicity good...

3D-printed titanium (Ti) materials have attracted much attention in the field of bone tissue repair. However, combination strength traditional alloy with is lower, and elastic modulus higher than that natural tissue, which makes susceptible to stress shielding phenomena after implantation. Therefore, it urgent find better surface modification technology. In this study, physical chemical properties, toxicity, proliferation adipose stem cells composite graphene-coated (Gr–Ti) were investigated...

Skin cutaneous melanoma (SKCM) is one of the most aggressive and life-threatening cancers with high incidence rate, metastasis rate mortality. Early detection stratification risk assessment are essential to treat SKCM improve survival rate. The aim this study construct an immune-related lncRNAs (immlncRNAs) prognosis model identify immune biomarkers for early diagnosis, target immunotherapy SKCM. For purpose, we identified 46 immlncRNAs significantly correlated prognostic patients were...

Gliomas are the most prevalent primary malignant brain tumors worldwide. Growing evidences indicate that circular RNAs (circRNAs) play an important role in regulation of biological behavior tumors. We aimed to investigate and mechanism circVCAN glioma. RNase R treatment was utilized assess cyclic properties circVCAN. CircVCAN, miR-488-3p, myocyte enhancer factor 2C (MEF2C) levels glioma tissues cells were detected by reverse transcription real-time polymerase chain reaction (RT-qPCR),...

It is a significant challenge to flexible wearable sensors that incur unstable output signals and malfunction because of omnipresent low-frequency vibrations. Because their design in terms molecular friction almost the opposite elasticity material, current sensing soft materials possess adequate but inadequate damping vibration. In contrast, using highly damaging for challenging due substantial hysteresis. Herein, self-damping ionic elastomer with heterogeneous two-phase structure introduced...

Abstract Background: Human adipose-derived stem cells (hADSCs) are with the potential to differentiate in multiple directions. MiR-204-5p is expressed at low levels during osteogenic differentiation of hADSCs, and its specific regulatory mechanism remains unclear. Here, we aimed explore function possible molecular miR-204-5p hADSCs. Methods: The expression patterns miR-204-5p, Runx2, alkaline phosphatase (ALP), osteocalcin (OCN), forkhead box C1 (FOXC1) growth factor 7 (GDF7) hADSCs...

Abstract Background: Human adipose-derived stem cells (hADSCs) are with the potential to differentiate in multiple directions. MiR-204-5p is expressed at low levels during osteogenic differentiation of hADSCs, and its specific regulatory mechanism remains unclear. Here, we aimed explore function possible molecular miR-204-5p hADSCs. Methods: The expression patterns miR-204-5p, Runx2 , alkaline phosphatase ( ALP ), osteocalcin OCN forkhead box C1 FOXC1 ) growth factor 7 GDF7 hADSCs...

Abstract Background: Human adipose-derived stem cells (hADSCs) are with the potential to differentiate in multiple directions. MiR-204-5p is poorly expressed during osteogenic differentiation of hADSCs, and its specific regulatory mechanism remains unclear. Here, we aimed explore function possible molecular miR-204-5p involved hADSCs. Methods: The expression pattern miR-204-5p, Runx2, Alkaline phosphatase (ALP), Osteocalcin (OCN), Forkhead box C1(FOXC1) growth factor 7(GDF7) hADSCs...