A5013127948- Trace Elements in Health
- Antifungal resistance and susceptibility
- Plant Disease Resistance and Genetics
- Wheat and Barley Genetics and Pathology
- Polysaccharides and Plant Cell Walls
- Viral Infections and Immunology Research
- Fungal Infections and Studies
- Polysaccharides Composition and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Nanocomposite Films for Food Packaging
- Cancer-related gene regulation
- Synthesis of heterocyclic compounds
- Genetics and Plant Breeding
- Myasthenia Gravis and Thymoma
- Plant Pathogens and Fungal Diseases
- Fern and Epiphyte Biology
- Mycotoxins in Agriculture and Food
- Plant and Fungal Species Descriptions
- Plant Micronutrient Interactions and Effects
- Yeasts and Rust Fungi Studies
- Alzheimer's disease research and treatments
- Sulfur-Based Synthesis Techniques
- Peptidase Inhibition and Analysis
- S100 Proteins and Annexins
- MicroRNA in disease regulation
Peking University Cancer Hospital
2024-2025
Peking University
2024-2025
Xi'an University of Technology
2024
Shandong Agricultural University
2020-2024
Tianjin Medical University
2018-2024
Chongqing Jiaotong University
2024
Nanjing Brain Hospital
2013-2024
Nanjing Medical University
2013-2024
Jiangnan University
2024
Beijing Botanical Garden
2022-2023
Fungal disease meets its match Fusarium head blight (FHB), caused by a fungus, reduces wheat crop yield and introduces toxins into the harvest. From assembly of genome Thinopyrum elongatum , wild relative used in breeding programs to improve cultivated wheat, Wang et al. cloned gene that can address both problems (see Perspective Wulff Jones). The encoded glutathione S -transferase detoxifies trichothecene toxin and, when expressed confers resistance FHB. Science this issue p. eaba5435 ; see also 822
Hemophilia A, a bleeding disorder resulting from F8 mutations, can only be cured by gene therapy. A promising strategy is CRISPR-Cas9-mediated precise insertion of in hepatocytes at highly expressed loci, such as albumin (Alb). Unfortunately, the vivo integration efficiency long insert very low (~ 0.1%).We report that use double-cut donor leads to 10- 20-fold increase liver editing efficiency, thereby completely reconstituting serum activity mouse model hemophilia after hydrodynamic...
Background & AimsA common variant in the solute carrier family 39 member 6 gene (SLC39A6) has been associated with survival times of patients esophageal squamous cell carcinoma (ESCC). We investigated function SLC39A6 and ways which this affects tumor progression by studying ESCC samples lines.MethodsSLC39A6 was expressed or knocked down expression short hairpin RNAs cells (KYSE30 KYSE450) HeLa using lentiviral vectors; we analyzed effects on proliferation, colony formation, migration,...
In plants, the mechanism for ecological sympatric speciation (SS) is little known. Here, after ruling out possibility of secondary contact, we show that wild emmer wheat, at microclimatically divergent microsite "Evolution Canyon" (EC), Mt. Carmel, Israel, underwent triple SS. Initially, it split following a bottleneck an ancestral population, and further diversified to three isolated populations driven by disruptive selection. Remarkably, two postzygotically (SFS1 SFS2) sympatrically...
Immune checkpoint inhibitors (ICIs) are emerging promising agents for the treatment of patients with esophageal squamous cell carcinoma (ESCC), however, there only a small proportion respond to ICI therapy. Therefore, selecting candidate who will benefit most from these drugs is critical. However, validated biomarkers predicting immunotherapy response and overall survival lacking. As fundamental principle therapy T cell-mediated tumor killing (TTK), we aimed develop unique TTK-related gene...
The maintenance of cellular calcium homeostasis is associated with signalling transduction and the functions many membrane compartments, especially endoplasmic reticulum (ER) function. ER-localized proteins that serve to maintain ER in Candida albicans are still unclear. In this study, Spf1, putative C. homologue Saccharomyces cerevisiae P-type ATPase ScSpf1, was investigated for its roles homeostasis, hyphal development virulence. We constructed an Spf1 null mutant which showed decreased...
// Chunling Liu 1, * , Huan Guo 2, Xinxin Cheng 1 Mingming Shao Chen Wu Suhan Wang 2 Hongmin Li Lixuan Wei Yanning Gao Wen Tan Shujun Tangchun Dianke Yu Dongxin Lin State Key Laboratory of Molecular Oncology and Department Etiology Carcinogenesis, Cancer Institute Hospital, Chinese Academy Medical Science Peking Union College, Beijing, China Occupational Environmental Health Ministry Education Lab for Environment Health, School Public Huazhong University Sciences Technology, Wuhan, These...
Zinc transporters have been found to be associated with the pathogenesis of numerous human diseases including cancer. As most lethal gynecologic malignancy, ovarian cancer is characterized by rapid progression and widespread metastases. However, function underlying mechanism zinc in metastasis remain unclear.The relationship between transporter gene expressions clinical outcomes was assessed online database Kaplan-Meier plotter ( http://kmplot.com/analysis/ ). Immunohistochemistry performed...
Background: Mild cognitive impairment (MCI) is considered to be a transitional state between normal aging and Alzheimer's dementia (AD). Recent studies have indicated that executive function (EF) declines during MCI. However, only limited number of investigated the neural basis EF deficits in Herein, we investigate changes regional brain spontaneous activity functional connectivity (FC) control network (ECN) high low groups. Methods: According composite score (ADNI-EF) from Disease...
Iron is an essential element required for most organisms. The high-affinity iron-uptake systems in the opportunistic pathogen Candida albicans are activated under iron-limited conditions and also virulence. Here one component of systems, multicopper oxidase (MCO) genes, was characterized. We examined expression five MCO genes demonstrated that CaFET3 CaFET34 were major response to iron deficiency. Complementation Saccharomyces cerevisiae fet3Δ mutant showed could effectively rescue growth...
Background Motor imagery therapy (MIT) showed positive effects on upper limbs motor function. However, the mechanism by which MIT improves limb function is not fully understood. Therefore, our purpose was to investigate changes in functional connectivity (FC) within and outside sensorimotor network (SMN) induced associated with improvement stroke patients. Methods A total of 26 hemiplegic patients were randomly divided into ( n = 13) control groups. Fugl-Meyer Assessment Upper Extremity...
Zinc homeostasis has been known to play a role in myocardial ischemia/reperfusion (I/R) injury, but the precise molecular mechanisms regulating expression of ZIP transporters during reperfusion are still unclear. The aim this study was determine whether ER Stress/CaMKII/STAT3 pathway plays regulation cellular zinc homeostasis. deficiency increased mRNA and protein expressions stress relevant markers Chop Bip, STAT3 phosphorylation H9c2 or HL-1 cells, an effect that abolished by ZnCl2....