A5100361790- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Renal and related cancers
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Endoplasmic Reticulum Stress and Disease
- Renal cell carcinoma treatment
- Genetic and Kidney Cyst Diseases
- Genetics and Neurodevelopmental Disorders
- Nuclear Structure and Function
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Soil and Water Nutrient Dynamics
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Tuberous Sclerosis Complex Research
- Soil Carbon and Nitrogen Dynamics
- Cancer-related Molecular Pathways
- Organ Donation and Transplantation
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Developmental Biology and Gene Regulation
- RNA regulation and disease
- Hearing Loss and Rehabilitation
The First Affiliated Hospital, Sun Yat-sen University
2022-2025
Sun Yat-sen University
2010-2025
Chengdu Institute of Biology
2024
Chinese Academy of Sciences
2013-2024
Chongqing Cancer Hospital
2024
Chongqing University
2024
Academia Sinica
2024
Columbia University
2022-2023
Jiangxi Provincial Cancer Hospital
2023
Columbia University Irving Medical Center
2023
Abstract In developing vertebrate embryos, Pax3 is expressed in the neural tube and paraxial mesoderm that gives rise to skeletal muscles. mutants develop muscular defects; furthermore, essential for proper activation of myogenic determination factor gene, MyoD, during early muscle development PAX3 chromosomal translocations result tumors, providing evidence has diverse functions myogenesis. To investigate specific development, we have examined cell survival gene expression presomitic...
Abstract The biosynthesis and metabolism of RNA play important roles in regulating gene expression. On the other hand, it has been shown that expression profiling is differentially distinct between cancer normal cells, suggesting possibility aberrant regulation might be associated with development progression cancer. In current study, we found Sam68, an RNA‐binding protein links cellular signalling to processing, was markedly overexpressed breast cells tissues. Immunohistochemical analysis...
Background & AimsA common variant in the solute carrier family 39 member 6 gene (SLC39A6) has been associated with survival times of patients esophageal squamous cell carcinoma (ESCC). We investigated function SLC39A6 and ways which this affects tumor progression by studying ESCC samples lines.MethodsSLC39A6 was expressed or knocked down expression short hairpin RNAs cells (KYSE30 KYSE450) HeLa using lentiviral vectors; we analyzed effects on proliferation, colony formation, migration,...
Abstract The transcription factor Six1 is essential for induction of sensory cell fate and formation auditory epithelium, but how it activates gene expression programs to generate distinct cell-types remains unknown. Here, we perform genome-wide characterization binding at different stages epithelium development find that Six1-binding cis-regulatory elements changes dramatically cell-state transitions. Intriguingly, pre-occupies enhancers cell-type-specific regulators effectors before their...
Background/Aims: Trastuzumab is an important treatment used for patients with Her-2-positive breast cancer, but increasing incidence of trastuzumab resistance has been observed clinically during the past decade. Aberrant microRNA (miR) expression levels are correlated prognosis and response to in cancer. MiR-129-5p downregulated trastuzumab-resistant human cancer cells (JIMT-1), its potential function underlying mechanism remain unclear. Methods: Quantitative RT-PCR (qRT-PCR) was determine...
EYA1 is known to be overexpressed in human breast cancer, which the Myc protein also accumulated association with decreased phospho-T58 (pT58) levels. We have recently reported that functions as a unique phosphatase dephosphorylate at pT58 regulate However, it remains unclear whether EYA1-mediated dephosphorylation on T58 critical function regulating stability cancer. Furthermore, EYA1's substrate specificity has remained elusive. In this study, we investigated these questions, and here,...
Chondrocyte hypertrophy is the terminal step in chondrocyte differentiation and crucial for endochondral bone formation. How signaling pathways regulate hypertrophic remains incompletely understood. In this study, using a Tbx18:Cre (Tbx18Cre/+) gene-deletion approach, we selectively deleted gene protein SMAD family member 4 (Smad4f/f ) limbs of mice. We found that Smad4-deficient mice develop prominent shortened limb, with decreased expression markers, including Col2a1 Acan, humerus at...
Acute kidney injury (AKI) is a common, complex, and severe clinical syndrome characterized by rapid decline in renal function, combined with tissue damage. Currently, the prevention treatment of AKI are focused on symptomatic treatment, rather than treating underlying causes. Therefore, there no specific to prevent except for dialysis. In this study, we used cisplatin-induced mouse human kidney-2 (HK-2) cell models evaluate protective effect eleutheroside B, an active compound traditional...
Abstract Biogenesis of organelles requires targeting a subset proteins to specific subcellular domains by signal peptides or mechanisms controlling mRNA localization and local translation. How distribution translation mRNAs for organelle biogenesis is achieved remains elusive likely be dependent on the cellular context. Here we identify Trinucleotide repeat containing-6a ( Tnrc6a ), component miRNA pathway, distinctively localized apical granules differentiating airway multiciliated cells...
The mechanism of alternative pre-mRNA splicing (AS) during preimplantation development is largely unknown. In order to capture the dynamic changes AS occurring embryogenesis, we carried out bioinformatics analysis based on scRNA-seq data over time-course in mouse. We detected numerous previously-unreported differentially expressed genes at specific developmental stages and investigated nature both minor major zygotic genome activation (ZGA). differential atlas were established. alternatively...
SRrp86 is a unique member of the SR protein superfamily containing one RNA recognition motif and two serine-arginine (SR)-rich domains separated by an unusual glutamic acid-lysine (EK)-rich region.Previously, we showed that could regulate alternative splicing both positively negatively modulating activity other proteins EK domain inhibit constitutive splicing.These functions were most consistent with model in which interacting thereby target proteins.To identify specific interact SRrp86,...