A5101444791- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Esophageal Cancer Research and Treatment
- Death Anxiety and Social Exclusion
- Physical Education and Training Studies
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Technology Adoption and User Behaviour
- Cancer Research and Treatments
- Mycobacterium research and diagnosis
- Cancer Immunotherapy and Biomarkers
- Industrial Vision Systems and Defect Detection
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Smart Agriculture and AI
- Spectroscopy and Chemometric Analyses
- Tuberculosis Research and Epidemiology
- Gastrointestinal Tumor Research and Treatment
- Technology and Data Analysis
- Digital Marketing and Social Media
- Transgenic Plants and Applications
- Face recognition and analysis
- Wnt/β-catenin signaling in development and cancer
Capital Medical University
2023
Xinjiang University
2023
Beijing Chao-Yang Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2021
Nanjing Normal University
2021
Academy of Medical Sciences
2020
Capital University of Physical Education and Sports
2020
Guangdong Baiyun University
2020
National Clinical Research
2019
Jining First People's Hospital
2019
Abstract Approximately half of the world’s 500,000 new oesophageal squamous-cell carcinoma (ESCC) cases each year occur in China. Here, we show whole-genome sequencing DNA and RNA 94 Chinese individuals with ESCC. We identify six mutational signatures (E1–E6), Signature E4 is unique ESCC linked to alcohol intake genetic variants alcohol-metabolizing enzymes. discover significantly recurrent mutations 20 protein-coding genes, 4 long non-coding RNAs 10 untranslational regions. Functional...
Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate composition ESCC tumors based on 208,659 single-cell transcriptomes derived from 60 individuals. We identify 8 common expression programs epithelial cells discover 42 cell types, including 26 immune 16 nonimmune stromal subtypes in microenvironment (TME), analyse interactions between cancer other among different types TME....
Papillary thyroid carcinoma (PTC) is the most common type of cancer. However, we know little mutational spectrum in Chinese population. Thus, here report identification somatic mutations for PTC using 402 tumor-normal pairs (Discovery: 91 via exome sequencing; validation: 311 Sanger sequencing). We observed three distinct signatures, evidently different from two signatures among Caucasian PTCs. Ten significantly mutated genes were identified, previously uncharacterized. Notably, found that...
With the rapid development of mobile devices, users can now read on screen. Electronic reading (e-reading) has become a common style with growth in online learning or electronic (e-learning). E-book applications (APPs) are widely developed and applied for However, it is difficult readers to change their habits preference from paper-printed books digital devices. The study readers' continuance intention use e-book APPs first step improving e-reading. This focuses influential factors...
Background & AimsA common variant in the solute carrier family 39 member 6 gene (SLC39A6) has been associated with survival times of patients esophageal squamous cell carcinoma (ESCC). We investigated function SLC39A6 and ways which this affects tumor progression by studying ESCC samples lines.MethodsSLC39A6 was expressed or knocked down expression short hairpin RNAs cells (KYSE30 KYSE450) HeLa using lentiviral vectors; we analyzed effects on proliferation, colony formation, migration,...
Inhibitory control is a sub-ability of executive function and plays an important role in the entire cognitive process. However, declines inhibitory during aging significantly impair quality life elderly people. Investigating methods to delay decline has become focal point current research. Tai Chi Chuan (TCC) one effective method used older adults. specific effects TCC on mechanisms through which may improve cognition adults have not been comprehensively investigated.The study explores...
Scratch, a kind of visual programming software, has been widely used in instruction for primary school children. Scratch constructs digital world children to design, develop, and create coursework which their creative thinking is fostered. Different instructional methods have designed implemented stimulate children’s skills through coursework. This study investigated whether scaffolding construction with mind mapping promoted course. Two groups 84 fifth-grade pupils participated the study....
// Chunling Liu 1, * , Huan Guo 2, Xinxin Cheng 1 Mingming Shao Chen Wu Suhan Wang 2 Hongmin Li Lixuan Wei Yanning Gao Wen Tan Shujun Tangchun Dianke Yu Dongxin Lin State Key Laboratory of Molecular Oncology and Department Etiology Carcinogenesis, Cancer Institute Hospital, Chinese Academy Medical Science Peking Union College, Beijing, China Occupational Environmental Health Ministry Education Lab for Environment Health, School Public Huazhong University Sciences Technology, Wuhan, These...
Rationale: Whole-genome sequencing has identified many amplified genes in esophageal squamous-cell carcinoma (ESCC).This study investigated the role and clinical relevance of these ESCC.Methods: We collected ESCC non-tumor tissues from 225 individuals who underwent surgery.Clinical data were survival time was measured date diagnosis to last follow-up or death.Patient compared with immunohistochemical staining score using Kaplan-Meier methods hazard ratios calculated by Cox models.Cells gene...
Adenocarcinoma at the gastroesophageal junction (ACGEJ) has dismal clinical outcomes, and there are currently few specific effective therapies because of limited knowledge on its genomic transcriptomic alterations. The present study investigates changes in ACGEJ from Chinese patients analyzes their drug vulnerabilities associations with survival time. Here we show that major chromosome instability promoted tumorigenic focal copy-number variations COSMIC Signature 17-featured single...
Aims: The aim of the present study was to investigate role endoplasmic reticulum stress and apoptosis in experimental diabetic nephropathy. effects ACE inhibitor on were also assessed.
Genetic variation (rs372883C/T) in the 3'-untranslated region of BTB and CNC homology 1 (BACH1) has been associated with pancreatic ductal adenocarcinoma (PDAC) risk our previous genome-wide association study; however, action roles this genetic PDAC remains unknown.Methods: BACH1 expression was measured by quantitative real-time PCR, Western blot immunohistochemistry.The effects on cell proliferation sensitivity to gemcitabine were examined alteration cells.Angiogenesis determined vitro...
Abstract Esophageal squamous-cell carcinoma (ESCC) is one of the most lethal malignancies in world and occurs at particularly higher frequency China. While several genome-wide association studies (GWAS) germline variants whole-genome or whole-exome sequencing somatic mutations ESCC have been published, there no comprehensive database publically available for this cancer. Here, we developed Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma (CCGD-ESCC) database, which contains...
Background Lung cancer is the second most commonly diagnosed and leading cause of cancer-related death. Malignant pleural effusion (MPE) a special microenvironment for lung metastasis. Alternative splicing, which regulated by splicing factors, affects expression genes influences carcinogenesis Methods mRNA-seq data alternative events in adenocarcinoma (LUAD) were obtained from The Cancer Genome Atlas (TCGA). A risk model was generated Cox regression analyses LASSO regression. Cell isolation...
The purpose of this work was to achieve non-destructive detection the internal defects in-shell walnuts using X-ray radiography technology based on improved Faster R-CNN network model. First, FPN structure added feature extraction layer extract richer image information. Then ROI Align used instead Pooling for eliminating localization bias problem caused by quantization operation. Finally, Softer-NMS module introduced final regression with predicted bounding box improving accuracy candidate...
Executive function (EF) plays an important role in controlling human actions. Shooting is a closed motor skill, characterized by high anti-interference ability and mental intensity. However, the beneficial effects of exercises such as shooting on EF remain unclear.We utilized expert-novice paradigm Flanker task to examine athletes. Participants were assigned into novice group, expert or control based level training competition experience. Reaction time (RT) accuracy performance across three...
Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal malignant disease, has a complex but unknown tumor ecosystem. Here, we decipher for first time full compositions ESCC based on analyzing 208,659 single-cell transcriptomes in derived from 60 individuals. We identify 8 essential expression programs epithelial cells discovered 43 cell types including 26 immune 17 nonimmune stromal subtypes microenvironment (TME), also explicate interactions between cancer other...
Background:Fibroblast growth factor 9 (FGF9) is reported to be associated with the pathogenesis of cancers. However, its clinic significance in prostate cancer (PCa) had not yet elucidated. The aim this study was investigate diagnostic value FGF9 PCa. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analyses were used detect expression serum at mRNA protein level 90 PCa patients, 48 prostatic benign diseases (PBD) patients 30 normal individuals....
Genome-wide association studies (GWAS) have consistently identified PLCE1 as esophageal squamous cell carcinoma (ESCC) susceptibility gene; however, the functional role of variants remains to be verified. In this study, we performed fine mapping region using our previous ESCC GWAS data and 33 additional risk in locus. Here, report characterization a four-nucleotide insertion/deletion variation (rs71031566 C----/CATTT) that was associated with developing ESCC. We demonstrate for first time...
The purpose of this study was to achieve non-destructive detection the internal defects in-shell walnuts using X-ray radiography technology based on improved Faster R-CNN network model. First, FPN structure added feature-extraction layer extract richer image information. Then, ROI Align used instead Pooling for eliminating localization bias problem caused by quantization operation. Finally, Softer-NMS module introduced final regression with predicted bounding box improving accuracy candidate...
Summary Whole-genome sequencing has identified many amplified genes in esophageal squamous-cell carcinoma (ESCC); however, their roles and the clinical relevance have yet elucidated. Here we show TP53-induced glycolysis apoptosis regulator (TIGAR) is a major player ESCC progression chemoresistance. TIGAR reprograms glucose metabolism from to glutamine pathway through AMP-activated kinase, its overexpression correlated with poor disease outcomes. Tigar knockout mice reduced growth tumor...