A5100389592- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Geological and Geochemical Analysis
- High-pressure geophysics and materials
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Luminescence and Fluorescent Materials
- Luminescence Properties of Advanced Materials
- Antibiotic Resistance in Bacteria
- Enterobacteriaceae and Cronobacter Research
- Animal Virus Infections Studies
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Genomics and Chromatin Dynamics
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Pancreatitis Pathology and Treatment
- Atmospheric chemistry and aerosols
- Phytochemical compounds biological activities
- Endoplasmic Reticulum Stress and Disease
- earthquake and tectonic studies
Nanjing Tech University
2024-2025
Nanjing Agricultural University
2014-2025
State Forestry and Grassland Administration
2025
Shandong Agricultural University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Peking Union Medical College Hospital
2019-2024
Beijing Center for Disease Prevention and Control
2024
Capital Medical University
2024
University of Missouri
2024
Henan Provincial People's Hospital
2024
Inorganic arsenic is a carcinogen, and its ingestion through foods such as rice presents significant risk to human health. Plants chemically reduce arsenate arsenite. Using genome-wide association (GWA) mapping of loci controlling natural variation in accumulation Arabidopsis thaliana allowed us identify the reductase required for this reduction, which we named High Arsenic Content 1 (HAC1). Complementation verified identity HAC1, expression Escherichia coli lacking functional confirmed...
Esophageal squamous-cell carcinoma (ESCC), one of the most prevalent and lethal malignant disease, has a complex but unknown tumor ecosystem. Here, we investigate composition ESCC tumors based on 208,659 single-cell transcriptomes derived from 60 individuals. We identify 8 common expression programs epithelial cells discover 42 cell types, including 26 immune 16 nonimmune stromal subtypes in microenvironment (TME), analyse interactions between cancer other among different types TME....
Light is a major environmental cue affecting various physiological and metabolic processes in plants. Although plant photoreceptors are well characterized, the mechanisms by which light regulates downstream responses less clear. In Arabidopsis thaliana, accumulation of photoprotective anthocyanin pigments dependent, R2R3 MYB transcription factor MYB75/PAP1 accumulation. Here, we report that MYB75 interacts with phosphorylated MAP KINASE4 (MPK4). Their interaction dependent on MPK4 kinase...
CHDTEPDB (URL: ) is a manually integrated database for congenital heart disease (CHD) that stores the expression profiling data of CHD derived from published papers, aiming to provide rich resources investigating deeper correlation between human and aberrant transcriptome expression. The development diseases involves important regulatory roles RNAs, can reflect underlying etiology inherited diseases. Hence, collecting compiling critical significance comprehensive understanding mechanisms...
Nanosized dual window afterglow particles possess X-ray rechargeable and photo-stimulation properties for long-term bioimaging.
ABSTRACT The porcine epidemic diarrhea virus (PEDV), a highly pathogenic coronavirus, poses significant challenges to global swine agriculture with severe economic consequences. Our research reveals that in addition known transmission routes, PEDV can be airborne, initially invading the nasal mucosa and subsequently being transported by dendritic cells peripheral blood T cells, ultimately leading intestinal disease piglets. This study elucidates cellular mechanisms behind process,...
A new cyanoacrylic acid derivative of carbazole-triphenylethylene as a fluorescent probe has been synthesized and characterized. The exhibits not only aggregation-induced effect (AIE) properties, but also interesting fluorescence multi-responses to solvents, water, ethanol metal ions due its chemical structure. Responses the compound solution in DMF water can be explained terms H-bond, multimer AIE effects. In addition, was found highly sensitive potassium ions. It is suggested that...
Summary Arsenic (As) is an important environmental and food‐chain toxin. We investigated the key components controlling As accumulation tolerance in Arabidopsis thaliana . tested effects of different combinations gene knockout, including arsenate reductase ( HAC 1 ), γ‐glutamyl‐cysteine synthetase (γ ‐ ECS phytochelatin synthase PCS ) phosphate effluxer PHO heterologous expression As‐hyperaccumulator Pteris vittata arsenite efflux Pv ACR 3 on tolerance, accumulation, translocation speciation...
Until now, the afterglow emissions of most developed near infrared (NIR)-emitting persistent luminescent nanoparticles (NPLNPs) were located at approximately 700 nm, edge first tissue transparency window (from 650 to 900 nm), which resulted in relatively low penetration and signal-to-noise ratio (SNR) for vivo imaging. Herein, 5 nm ZnSn2O4:Cr,Eu (ZSO) NPLNPs with NIR emission 800 are synthesized via a direct aqueous-phase synthesis method. The longer ZSO can easily penetrate 3 cm pork...
Significance By determining the structure of a pantothenate energy-coupling factor (ECF) transporter, Lb ECF-PanT, we revealed structural basis how one EcfAA'T module can interact with different S subunits among group II ECF transporters. We also identified residues that mediate intermolecular conformational transmission and/or affect transporter complex stability, and thus are essential for activity. In addition, pantothenate-binding pocket constituting pocket. Last but not least, found...
Abstract Background Pancreatic cancer (PC) is a highly malignant tumor featured with high intra-tumoral heterogeneity and poor prognosis. Cell-in-cell (CIC) structures have been reported in multiple cancers, their presence associated disease progression. Nonetheless, the prognostic values biological functions of CIC-related genes PC remain poorly understood. Methods The sequencing data, as well corresponding clinicopathological information were collected from public databases. Random forest...
Hepatocellular carcinoma (HCC) progression is closely linked to the role of macrophages. This study utilized single-cell RNA sequencing and genomic analysis explore characteristic genes macrophages in HCC their impact on patient prognosis. We obtained se-quencing data from seven samples GEO database. Through principal component t-SNE dimensionality reduction, we identified 2,000 highly variable per-formed clustering annotation 17 cell clusters, revealing 482 macrophage-related feature genes....
Molecular additives are widely used to improve the film quality and optoelectronic performance of solution-processed metal halides, owing their diverse interactions with metal-halide precursors. However, relationship between additive-precursor interaction strength halides remains unclear. In this study, we investigate cesium copper iodide (Cs–Cu–I) light-emitting diodes (LEDs) incorporating crown ether (CE) demonstrate that additive-Cs+ can significantly influence device performance. By...
Black locust (Robinia pseudoacacia L.) plantations transition from seedling to multi-generation coppice systems, leading declines in productivity and biodiversity. However, the structural functional reorganization of soil fungal communities during this remains poorly understood. This study aimed characterize community dynamics across successional stages black stands assess their implications for health ecosystem resilience. Soil three (first-generation forest, first- second-generation...
Based on 2,2′:6′,2′′-terpyridine ligands (L1), five terpyridine derivatives, namely 4′-carbazol-9-yl-2,2′:6′,2′′-terpyridine (L2), 4′-diphenylamino-2,2′:6′,2′′-terpyridine (L3), 4′-bis(4-tert-butylphenyl)amino-2,2′:6′,2′′-terpyridine (L4), 4′-[naphthalen-1-yl-(phenyl)amino]-2,2′:6′,2′′-terpyridine (L5), 4′-[naphthalen-2-yl(phenyl)amino]-2,2′:6′,2′′-terpyridine (L6) and their corresponding Re(I) complexes ReLnnn(CO)33Cl (n = 1–6) have been synthesized characterized by elemental analysis 1H...