A5066346618- Gut microbiota and health
- Esophageal Cancer Research and Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- RNA modifications and cancer
- Water Treatment and Disinfection
- Antibiotic Resistance in Bacteria
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Anaerobic Digestion and Biogas Production
- Colorectal Cancer Screening and Detection
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Probiotics and Fermented Foods
- Advanced biosensing and bioanalysis techniques
- Congenital heart defects research
- Zebrafish Biomedical Research Applications
- Immune cells in cancer
- Polyamine Metabolism and Applications
- Legionella and Acanthamoeba research
- Clostridium difficile and Clostridium perfringens research
- Multiple and Secondary Primary Cancers
Shanghai Sixth People's Hospital
2025
Shanghai Jiao Tong University
2025
Southeast University
2020-2024
Harbin Medical University
2017-2024
Second Affiliated Hospital of Harbin Medical University
2024
Nanjing Institute of Environmental Sciences
2020-2023
Ministry of Ecology and Environment
2020-2023
Zhejiang Zanyu Technology (China)
2023
Chung Shan Medical University Hospital
2023
Shantou University
2019-2020
Lnc2Cancer 2.0 (http://www.bio-bigdata.net/lnc2cancer) is an updated database that provides comprehensive experimentally supported associations between lncRNAs and human cancers. In 2.0, we have the with more data several new features, including (i) exceeding a 4-fold increase over previous version, recruiting 4989 lncRNA-cancer 1614 165 cancer subtypes. (ii) newly adding about 800 circulating, drug-resistant prognostic-related in various (iii) appending regulatory mechanism of lncRNA...
CHDTEPDB (URL: ) is a manually integrated database for congenital heart disease (CHD) that stores the expression profiling data of CHD derived from published papers, aiming to provide rich resources investigating deeper correlation between human and aberrant transcriptome expression. The development diseases involves important regulatory roles RNAs, can reflect underlying etiology inherited diseases. Hence, collecting compiling critical significance comprehensive understanding mechanisms...
Antibiotics, antimicrobial resistance determinants and human pathogens are new types of environmental pollutants that pose a great threat to health. Wastewater treatment plants (WWTPs) important sources novel pollutants; however, few studies have investigated their impact on surrounding natural water. Therefore, this study used WWTP as the entry point explore removal efficiency antibiotics, further analyze effluent receiving waters. The had good effect fluoroquinolones, macrolides,...
This study aimed to evaluate the efficacy and safety of intrathecal pemetrexed (IP) for treating patients with leptomeningeal metastases (LM) from non-small-cell lung cancer (NSCLC) who progressed epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) treatment in an expanded, prospective, single-arm, phase II clinical (ChiCTR1800016615).
Lnc2Meth (http://www.bio-bigdata.com/Lnc2Meth/), an interactive resource to identify regulatory relationships between human long non-coding RNAs (lncRNAs) and DNA methylation, is not only a manually curated collection annotation of experimentally supported lncRNAs-DNA methylation associations but also platform that effectively integrates tools for calculating identifying the differentially methylated lncRNAs protein-coding genes (PCGs) in diverse diseases. The provides: (i) advanced search...
The pathogenesis of chronic urticaria (CU) is closely related to imbalances in immunity. gastrointestinal microflora provides a vast and continuous stimulation for the immune system. However, composition diversity gut CU patients are rarely reported.10 10 healthy individuals were selected this study, their intestinal microbiome was detected by 16S rRNA sequencing. data analyzed using R language software.392 bacterial OTUs common groups, but there 159 particularly existing group, while 87...
BackgroundKARS encodes both mitochondrial and cytoplasmic lysyl-tRNA synthetase, which is one of the aminoacyl-tRNA synthetases (ARSs) necessary for protein translation. Pathogenic variants in KARS have been reported to be involved hearing loss, visual disorders, neuropathology, diseases combined with multisystem phenotypes. In vitro studies shown that mutations cause a decrease aminoacylation. However, pathogenetic mechanisms underlying complex neurological phenotypes remain largely...
Sex differences in glioma incidence and outcome have been previously reported but remain poorly understood. Many sex that affect the cancer risk were thought to be associated with evolution. In this study, we used an integrated framework infer timing clonal status of mutations ~600 diffuse gliomas from The Cancer Genome Atlas (TCGA) including glioblastomas (GBMs) low-grade (LGGs), investigated difference mutation clonality. We observed higher overall subclonal burden female patients...
Somatic mutations have long been recognized as an important feature of cancer. However, analysis somatic mutations, to date, has focused almost entirely on the protein coding regions genome. The potential roles in human noncoding RNAs (lncRNAs) are therefore largely unknown, particularly their functional significance across different cancer types. In this study, we characterized some lncRNAs whose expression was affected by (defined MutLncs) and constructed global MutLnc landscapes 17 types...
Previous studies have shown the role of bacterial lipopolysaccharide (LPS) in promoting tumor progression. Our previous study found that community richness LPS-producing bacteria was significantly increased fresh stool samples esophageal cancer (EC) patients, but relative LPS levels and underlying mechanism EC progression remain unknown. In this study, an case-control content higher serum patients. Functional experiments CCK8 assay transwell showed contributed to proliferation, migration,...
It is known that an imbalance in the intestinal f lora plays a crucial role colorectal cancer (CRC), but effect of food consumption patterns on types flora remains to be clarified. We aimed analyze associations between intake and healthy CRC individuals.Food data were recorded using Food Frequency Questionnaire (FFQ). The composition diversity detected by 16S rRNA gene sequencing, analyzed R version 3.1.1 software.Higher red meat or pickled foods, lower white meat, fruits, vegetables, beans,...
OBJECTIVE: Intestinal microbiota plays a vital role in the pathogenesis of colorectal cancer (CRC), which is crucial for assessing risk and prognosis CRC. Most studies regarding human gut mainly based on feces, but exact composition vary significantly due to fecal easily affected by many factors. We aim evaluate whether intestinal lavage fluid (IVF) better substitution mirroring microbiota. METHODS: performed 16S rRNA gene analysis IVF samples from 30 CRC patients 25 healthy individuals,...
The cancer microbiota was considered the main risk factor for progression. We had proved that Fusobacterium periodonticum (F.p) higher abundance in Esophageal cancer(EC)tissues. Bioinformation analysis found BCT a key virulence protein of F.p. However, little is known about role and mechanism EC. This study aimed to recognize F.p explore promoting
N-Nitrosamine disinfection by-products (NAs-DBPs) have been well proven for its role in esophageal carcinogenesis. However, the of intratumoral microorganisms squamous cell carcinoma (ESCC) has not yet explored context exposure to NAs-DBPs. Here, multi-omics integration reveals