A5057749307- Hearing, Cochlea, Tinnitus, Genetics
- Noise Effects and Management
- Hearing Loss and Rehabilitation
- Carcinogens and Genotoxicity Assessment
- Vestibular and auditory disorders
- Cerebral Venous Sinus Thrombosis
- Organ and Tissue Transplantation Research
- Ear Surgery and Otitis Media
- Autophagy in Disease and Therapy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Radiation Effects and Dosimetry
- Pharmacological Effects of Natural Compounds
- Horticultural and Viticultural Research
- Animal Genetics and Reproduction
- Congenital Ear and Nasal Anomalies
- Photosynthetic Processes and Mechanisms
- Zebrafish Biomedical Research Applications
- Ferroptosis and cancer prognosis
- Plant-Microbe Interactions and Immunity
- Genetic and phenotypic traits in livestock
- Calpain Protease Function and Regulation
- Ginseng Biological Effects and Applications
- Aquaculture disease management and microbiota
- Glioma Diagnosis and Treatment
- Plant Gene Expression Analysis
Southwest Jiaotong University
2025
Capital Medical University
1998-2025
Beijing Tian Tan Hospital
2025
Zhejiang University
2017-2025
Shanghai Jiao Tong University
2018-2021
Shanghai Sixth People's Hospital
2018-2021
Nantong University
2019-2020
Wuxi No.2 People's Hospital
2020
Nanjing Medical University
2020
Animal Science Research Institute
2015
Glycyrrhizic acid (GA) is the main active ingredient extracted from Chinese herb licorice root, and it shows anti-tumor effects in many cancer types, while its role gastric (GC) still unknown. In this study, we evaluated of GA on GC cells explored underlying mechanisms.
Sperm typing is an effective way to study recombination rate on a fine scale in regions of interest. There are two strategies for the amplification single meiotic recombinants: repulsion-phase allele-specific PCR and whole genome (WGA). The former can selectively amplify recombinant molecules from batch sperm but not scalable high-throughput operation. Currently, primer extension pre-amplification only method used WGA sperm, whereas it has limited capacity produce high-coverage products...
Brainstem gliomas (BSGs) harboring a histone 3 lysine27-to-methionine (H3K27M) mutation represent one of the deadliest brain tumors with dismal prognosis, as they exhibit much worse response to therapy compared wildtype BSGs. Early non-invasive recognition H3K27M is paramount for clinical decision-making in treating Plasma and urine samples were prospectively collected from BSG patients before biopsy or surgical resection chronologically divided into discovery, test, validation cohorts....
Abstract Aims To investigate the associations among heteroplasmy levels (i.e. proportions of mutant and wild‐type mitochondrial DNA in same cell), function clinical severity m.3243A>G mutation. Methods A total 17 participants carrying mutation sex‐ age‐matched healthy controls were included this study. Heteroplasmy leukocytes, saliva urine sediment determined by pyrosequencing. The evaluation endocrinological, audiological ophthalmological examinations. Mitochondrial was peripheral blood...
Object: We aimed to identify the relationship between vertigo symptoms and involvement of vestibular dysfunction in sudden sensorineural hearing loss (SSNHL) contribution audiogram classification. Methods: A total 50 patients with unilateral SSNHL were retrospectively divided into group non-vertigo depending on presence vertigo. The involved end organs (VEOs) verified by a battery function tests including video head impulse test (vHIT), cervical vestibular-evoked myogenic potential (cVEMP),...
The bacterial strain M5al is a model for studying the molecular genetics of N2-fixation and engineering microbial production platform chemicals 1,3-propanediol 2,3-butanediol. Here, we present complete genome sequence M5al, which belongs to novel species closely related Klebsiella michiganensis. secretes plant cell wall-degrading enzymes colonizes rice roots but does not cause soft rot disease. also produces siderophores contains gene clusters synthesis transport yersiniabactin critical...
It is important to determine what frequencies and auditory perceptual measures are the most sensitive early indicators of noise-induced hearing impairment.To examine whether loss among shipyard workers increases more rapidly at extended high than clinical subtle processing deficits present in those with extensive noise exposure but little or no loss.This cross-sectional study collected audiometric data (0.25-16 kHz), survey questionnaires, levels from 7890 a Shanghai 2015 2019. Worsening was...
We aimed to assess the effect of noise exposure on bottom-up and top-down attention functions in industrial workers based behavioral brain responses recorded by multichannel electroencephalogram (EEG).In this cross-sectional study, 563 shipyard noise-exposed with clinical normal hearing were recruited for cognitive testing. Personal cumulative (CNE) was calculated long-term equivalent level employment duration. The performance tests compared between high CNE group (H-CNE, >92.2) low group;...
To optimize a protocol for the steroid administration approach idiopathic sudden sensorineural hearing loss (ISSNHL) in China.A questionnaire was distributed to otolaryngologists. The data on demographics, indications first-line and salvage treatment, such as intratympanic of steroids (ITS) postauricular (PAS), procedures were analyzed.74 respondents used oral steroids, 112 intravenous injections, 10 ITS 6 PAS monotherapy 135 or conjunction with injection treatment. Of 249 who ITS, 97.19%...
Twelve genes related to anthocyanin synthesis were isolated from the red flesh of kiwifruit cultivar, Actinidia chinensis var. 'Hongyang', by cDNA and SSH library sequencing homologue cloning. These include partial- or fulllength structural genes, chalcone synthase (CHS), isomerase (CHI), flavanone 3-hydroxylase (F3H), dihydroflavonol 4-reductase (DFR), leucoanthocyanin deoxygenase (LDOX), UDP-glucose: flavonoid 3-Oglucosyltransferase (UFGT) UDPG, regulatory as myeloblast (MYB)...
The objective of this study was to compare 12 bpduplication polymorphisms in exon 4 the κ-casein gene among 3 breeds/populations yak (Bos grunniens).Genomic DNA extracted from blood or muscle samples (N = 211) and a partial sequence amplified by polymerase chain reaction.A polyacrylamide gel electrophoresis assay products (169 bp) revealed 2 variants.These variants differed 12-bp duplication nucleotide corresponding amino acids 147-150 (Glu-Ala-Ser-Pro) 148-151 (Ala-Ser-Pro-Glu).The genotype...
Otosclerosis is characterized by abnormal bone remodeling in the osseous labyrinth and progressive hearing loss. Although etiology of otosclerosis not fully understood, both environmental genetic factors play important roles its pathogenesis. Here, we generated an induced pluripotent stem cell line using episomal plasmid vectors from peripheral blood mononuclear cells a 48-year-old male with otosclerosis. The morphology karyotype were normal. expression pluripotency markers was verified mRNA...
To explore if and how chronic noise exposure impairs auditory processing ability individual susceptibility.