Cisplatin is commonly used to treat cancers and associated with a significant risk of irreversible sensorineural hearing loss. However, no effective preventive strategies are available for cisplatin-induced HL. Therefore, efforts have been made discover new drugs protecting cochlear hair cells from damage. We found that phytochemical, aucubin, attenuated apoptosis, the production reactive oxygen species, mitochondrial dysfunction in House Ear Institute Organ Corti 1 cells. Moreover, aucubin...

Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors, but its side effects limit application. Ototoxicity, major adverse effect cisplatin, causes irreversible sensorineural hearing loss. Unfortunately, there are no effective approaches to protect against this damage. Autophagy has been shown exert beneficial in diseases models. However, role autophagy cisplatin-induced ototoxicity not well elucidated. In study, we aimed investigate whether novel activator...

Vestibular neuritis (VN) is a most common disorder that has comorbid presentation with acute vestibular syndrome (AVS) in the absence of cochlear symptom. Sudden sensorineural hearing loss (SSHL) continuous vertigo (SHLV) lasts more than 1 day another AVS. VN and SHLV can be easily differentiated by reference to their clinical features, namely without or involvement. Although are considered as two different disorders, pathophysiologies explained similar mechanisms. mechanisms underlying SSHL...

Object: We aimed to identify the relationship between vertigo symptoms and involvement of vestibular dysfunction in sudden sensorineural hearing loss (SSNHL) contribution audiogram classification. Methods: A total 50 patients with unilateral SSNHL were retrospectively divided into group non-vertigo depending on presence vertigo. The involved end organs (VEOs) verified by a battery function tests including video head impulse test (vHIT), cervical vestibular-evoked myogenic potential (cVEMP),...

Benign paroxysmal positional vertigo (BPPV) is the most common vestibular disorder affecting about 20% of dizzy patients. Early diagnosis and treatment can improve quality life for patients.We reviewed classifications different subtypes benign problems we encountered using diagnostic criteria Bárány Society.Both Dix-Hallpike maneuver supine roll test were performed on 568 patients, diagnoses made based patient history type provoked nystagmus (if any). Next, numbers patients with each subtype...

Hearing loss is the most common human sensory deficit. relies on stereocilia, inserted into cuticular plate of hair cells (HCs), where they play an important role in perception sound and its transmission. Although numerous genes have been associated with hearing loss, function many cell has yet to be elucidated. Herein, we focused nonerythroid spectrin αII (SPTAN1), abundant plate, surrounding rootlets stereocilia along plasma membrane. Interestingly, mice HC-specific Sptan1 knockout...

Objective To describe the clinical features of benign paroxysmal positional vertigo ( BPPV ) in children. Design A retrospective study. Setting Six children diagnosed with between March 2014 and 2015 were retrospectively evaluated. was using Dix‐Hallpike supine roll tests treated either modified Epley particle repositioning procedure or Lempert Gufoni manoeuvre. Follow‐up performed at 1‐week intervals until nystagmus disappeared during testing. Participants total six followed up for a period...

The clinical efficacy of triple semicircular canal occlusion (TSCO) and vestibular nerve resection (VNS) for patients with Ménière's disease has been unclear.To explore changes in symptoms after TSCO its advantages compared to the classical operation VNS Menière's disease.In total, 36 performed or at Shanghai Jiao Tong University Affiliated Sixth People's Hospital, China from May 2005 July 2021, all them were enrolled our study. Twelve underwent TSCO, 23 VNS, 1 had both treatments. We...

To explore the composition of vestibular disorders presenting with acute syndrome (AVS).We performed a case analysis 209 AVS patients between January 2016 and December 2020. These were grouped into different disorder categories according to relevant diagnostic criteria.We classified 14 categories, including 110 cases neuritis, 30 idiopathic sudden sensorineural hearing loss vertigo, 17 first attack continuous vertigo migraine, 15 Ramsay Hunt syndrome, 11 labyrinthitis secondary chronic...

To optimize a protocol for the steroid administration approach idiopathic sudden sensorineural hearing loss (ISSNHL) in China.A questionnaire was distributed to otolaryngologists. The data on demographics, indications first-line and salvage treatment, such as intratympanic of steroids (ITS) postauricular (PAS), procedures were analyzed.74 respondents used oral steroids, 112 intravenous injections, 10 ITS 6 PAS monotherapy 135 or conjunction with injection treatment. Of 249 who ITS, 97.19%...

Objective:To explore the epidemiological characteristics and to help accomplish accurate diagnosis treatment strategies by analyzing composition clinical features of various diseases with acute constant vertigo.Method:We retrospectively analyzed medical records (including name, sex, age, diabetes, hypertension, history vertigo, family history, etc.),otoneurological examination, vestibular function tests radiological examination patients syndrome.We classified according diagnostic criteria,...

Objective:To analyze the nystagmus characteristics of 9 patients with horizontal semicircular canal light cupula.Method:Patients who visited department otolaryngology Shanghai sixth people's hospital from September 2017 to December a typical history positional vertigo and roll test evoked geotropic direction changing that lasted more than one minute were enrolled in study.Nystagmus was monitored using videonystagmoscopy (VNG), parameters nystagmus,including latency, duration intensity...

Objective: To explore composition and characteristics of vertigo in children. Method:The diagnosis, medical history examinations 46 patients (≤17 years old) with were studied retrospectively. Result:Of the children enrolled this study, 19 BPVC(41.3%), 11 VM(23.9%),4 BPPV(8.7%), 3 unclassifiable vestibular syndrome(6.5%), 2 Meniere's disease (4.3%), 1 patient sudden deafness vertigo, labyrinthitis, paroxysmal, neuritis, head trauma, light cupula, benign paroxysmal torticollis (2.2%,...

We retrospectively analyzed 2 patients of unilateral Meniere's disease with downbeat nystagmus. Audiometric test, the Dix-Hallpike maneuver and supine roll test were performed. Both presented spontaneous nystagmus components, components exaggerated by maneuver. Spontaneous positional component can occur in disease, which may be resulted from excitation three semicircular canals.

Objective:To retrospectively analyze the characteristics of 100 cases with Dix-Hallpike test induced nystagmus, especially vertical downward component.Method:One hundred positive between December 2017 and January 2018 were included in this study. roll performed all patients, max slow phase velocity (SPV), latency duration positional nystagmus analyzed SPSS 22.0 software.Result:According to difference direction head-hanging position on test, patients classified into 9 types. When only...

Stereocilium is a component of the sensory cells inner ear and plays an important role in mechanotransduction. With development technologies such as gene editing, more genes/proteins’ functions are recognized. Actin composes core stereocilia crucial to maintenance stereocilia. At same time, other proteins located or cuticular plate also play role. Therefore, this article reviews actin protein related stereocilia, summarizes various stereocilia. Key words: Actin; Gene; stereocilium

Vestibular schwannomas (VS), which develop from the Schwann cells(SCs) of vestibular nerve, are most prevalent benign tumors cerebellopontine angle and internal auditory canal. Despite advances in treatment, cellular components mechanisms VS tumor progression remain unclear. Here, we performed single-cell RNA-seq on clinically surgically isolated samples sophisticated clarified their composition, including heterogeneous cell subtypes. Advanced bioinformatics analysis also revealed associated...