A5102753555- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Ion Channels and Receptors
- Mitochondrial Function and Pathology
- Bladder and Urothelial Cancer Treatments
- Electron Spin Resonance Studies
- Redox biology and oxidative stress
- Cancer-related Molecular Pathways
- Advanced biosensing and bioanalysis techniques
- Electrochemical Analysis and Applications
- Nanopore and Nanochannel Transport Studies
- Epigenetics and DNA Methylation
- RNA regulation and disease
- RNA Research and Splicing
- Vestibular and auditory disorders
Zhejiang University
2013-2025
First Affiliated Hospital Zhejiang University
2021
Shanghai Jiao Tong University
2018-2019
Shanghai Sixth People's Hospital
2019
The synapse between inner hair cells (IHCs) and type I spiral ganglion neurons (SGNs) has been identified as a sensitive structure to noise-induced damage in the mammalian cochlea. Since this provides major information pathway from cochlea auditory brain, it is important maintain its integrity. Neurotrophin-3 (NT-3) known play an role development functional maintenance of synapse. Application exogenous NT-3, or overexpression gene transgenic animal model, have shown value protect damage. In...
Detection of carcinogenesis-related miRNAs presents significant challenges due to their low abundance and high specificity, necessitating highly sensitive reliable analytical methods. Herein, we propose a generic in situ electrochemical biosensor for the effective detection by rationally integrating an entropy-driven DNA circuit (EDC) with tetrahedral scaffold. The key advancement this work is implementation nanostructures (TDNs) as both scaffold substrate EDC directly on electrode surface....
Hearing loss is the most common human sensory deficit. relies on stereocilia, inserted into cuticular plate of hair cells (HCs), where they play an important role in perception sound and its transmission. Although numerous genes have been associated with hearing loss, function many cell has yet to be elucidated. Herein, we focused nonerythroid spectrin αII (SPTAN1), abundant plate, surrounding rootlets stereocilia along plasma membrane. Interestingly, mice HC-specific Sptan1 knockout...
Since the first report of noise-induced synaptic damage in animals without permanent threshold shifts (PTSs), concept hidden hearing loss (NIHHL) has been proposed to cover functional deficits associated with synaptopathy. Moreover, potential deficit synaptopathy largely attributed auditory nerve fibers (ANFs) a low spontaneous spike rate (SSR). As this group ANFs is critical for coding at suprathreshold levels and noisy background, coding-in-noise (CIND) considered be main consequence...
ABSTRACTBladder cancer (BC) is the most expensive to manage on a per-patient basis, costing about $4 billion in total healthcare expenditure per annum America alone. Therefore, identifying natural compound for prevention of BC tremendous importance managing this disease. Previous studies have identified isorhapontigenin (ISO) as having an 85% preventive effect against invasive formation induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). The results showed here that ISO treatment...