A5042433008- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- FOXO transcription factor regulation
- Extracellular vesicles in disease
- Cell death mechanisms and regulation
- Wnt/β-catenin signaling in development and cancer
- Biochemical and Molecular Research
- NF-κB Signaling Pathways
- Polyamine Metabolism and Applications
- PI3K/AKT/mTOR signaling in cancer
- Natural Compounds in Disease Treatment
- Kruppel-like factors research
- Protein Tyrosine Phosphatases
Wenzhou Medical University
2017-2025
Zhejiang Lab
2022-2025
Second Hospital of Shandong University
2022-2025
New York University
2016-2024
Shandong University
2022-2024
Central Hospital of Zibo
2022
Background: Cancer cell-derived exosomal microRNAs (miRNAs) play critical role in orchestrating intercellular communication between tumor cells and microenvironmental factors, including lymphatic endothelial (LECs). Nevertheless, the functions underlying mechanisms of miRNAs metastasis lymphangiogenesis esophageal squamous cell carcinoma (ESCC) remain unclear. Methods: Small RNA sequencing, Gene Expression Omnibus (GEO) analysis qRT‒PCR were performed to identify candidate involved ESCC...
Since invasive bladder cancer (BC) can progress to life threatening metastases, understanding the molecular mechanisms underlying BC invasion is crucial for potentially decreasing mortality of this disease. Herein, it discovered that autophagy-related gene 7 (ATG7) remarkably overexpressed in human tissues. The knockdown ATG7 cells dramatically inhibits cell invasion, revealing a key player regulating invasion. Mechanistic studies indicate MIR190A responsible mRNA stability and protein...
Abstract Lacking effective therapeutic targets heavily restricts the improvement of clinical prognosis for patients diagnosed with esophageal squamous cell carcinoma (ESCC). Ubiquitin Specific Peptidase 21 (USP21) is dysregulated in plenty human cancers, however, its potential function and relevant molecular mechanisms ESCC malignant progression as well value translation remain largely unknown. Here, vitro vivo experiments revealed that aberrant upregulation USP21 accelerated proliferation...
Human bladder cancer (BC) is the fourth most common in United States. Investigation of strategies aiming to elucidate tumor growth and metastatic pathways BC critical for management this disease. Here we found that ATG7 expression was remarkably elevated human urothelial carcinoma N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-induced mouse invasive BC. Knockdown resulted a significant inhibitory effect on tumorigenic cells both vitro vivo by promoting p27 inducing cell cycle arrest at G2/M...
BACKGROUND: Since invasive bladder cancer (BC) is one of the most lethal urological malignant tumors worldwide, understanding molecular mechanisms that trigger migration, invasion, and metastasis BC has great significance in reducing mortality this disease. Although RelA/p65, a member NF-kappa B transcription factor family, been reported to be upregulated human BCs, its regulation motility have not explored yet. METHODS: NF-κBp65 expression was evaluated...
Our recent studies demonstrate that X-linked inhibitor of apoptosis protein (XIAP) is essential for regulating colorectal cancer invasion. Here, we discovered RhoGDIβ was a key XIAP downstream effector mediating bladder (BC) invasion in vitro and vivo. We found both expressions were consistently elevated BCs N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-treated mice comparison to tissues from vehicle-treated human the paired adjacent normal tissues. Knockdown attenuated expression reduced...
Invasive bladder cancer (BC) is one of the most lethal malignant urological tumors. Although miR-200a has been reported as an onco-miRNA that targets PTEN gene in endometrioid carcinoma, its biological significance BC invasion poorly explored. In current study, we found was markedly overexpressed both human tissues and BBN-induced muscle-invasive tissues. We further showed overexpression specifically promoted cell invasion, but not migration, via transcriptional upregulation matrix...
Programmed cell death protein 1 (PD-1) and its ligand PD-L1 blockade have been identified to target immune checkpoints treat human cancers with durable clinical benefit. Several studies reveal that the response PD-1-PD-L1 might correlate expression levels in tumor cells. However, mechanistic pathways regulate are not understood. Here, we reported is regulated by ATG7-autophagy an ATG7-initiated positive feedback loop bladder cancer (BC). Mechanistic revealed ATG7 overexpression elevates...
Abstract Esophageal squamous carcinoma (ESCC) is the major subtype of esophageal cancer in China, accounting for 90% cases. Recent studies revealed that abnormalities Hippo/YAP axis are pervasive ESCC and recognized as important driver progression. Since activity Hippo signaling controlled by phosphorylation cascade, it a mystery why effector YAP still over-activated when cascade inhibited. Several suggested addition to phosphorylation, other protein modifications such ubiquitination also...
Increasing evidence has shown that circular RNAs (circRNAs) interact with RNA-binding proteins (RBPs) and promote cancer progression. However, the function mechanism of circRNA/RBP complex in esophageal squamous cell carcinoma (ESCC) are still largely unknown. Herein, we first characterized a novel oncogenic circRNA, circ-FIRRE, by RNA sequencing (Ribo-free) profiling ESCC samples. Furthermore, observed marked circ-FIRRE overexpression patients high TNM stage poor overall survival....
Cigarette smoking (CS) is one of the greatest health concerns, which can cause lung cancer. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, and has been well-documented for its carcinogenic activity in both epidemiological laboratory studies. PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) tensin homolog (PTEN) are two well-known tumor suppressors that have reported to be downregulated human cancer tissues. However, effect NNK exposure on...
Although microRNAs (miRNAs) are well-known for their potential in cancer, the function and mechanisms of miR-3648 have barely been explored any type cancer. We show here that is upregulated human BC tissues comparison with adjacent non-tumor tissues. Functional studies showed inhibition expression invasive UMUC3 T24T cell lines decreased migration invasion vitro suppressed lung metastasis vivo, whereas overexpression promoted invasion. A bioinformatics screen mRNA 3′ UTR luciferase reporter...
Although basal muscle-invasive bladder cancers (MIBCs) are predominant, more aggressive, and have bad prognoses, molecular mechanisms underlying how MIBC formation/progression been barely explored. In the present study, SNHG1, a long non-coding RNA, was shown to be expressed at higher levels in cells than other types of BC cells, its presence could promote cell invasion. The results revealed that SNHG1 specifically induced MMP2 expression via increasing transcription mRNA stability. one...
The X-linked inhibitor of apoptosis protein (XIAP) contains three N-terminal BIR domains that mediate anti-apoptosis and one C-terminal RING finger domain whose function(s) are not fully defined. Here we show the XIAP strongly inhibits expression p63α, a known tumor suppressor. knockdown in urothelial cells or deletion knockin mice markedly upregulates p63α expression. This RING-mediated downregulation is critical for malignant transformation normal following EGF treatment. We further...
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) is a newly identified family of Ser/Thr phosphatases that catalyzes the dephosphorylation conserved regulatory motif AGC kinases resulting in tumor suppressive function, while CDKN1B/p27 also acts as suppressor by regulating cell cycle, senescence, apoptosis, motility. Our most recent studies reveal CDKN1B required for abundance, which contributes to inhibition carcinogenic arsenite-induced malignant transformation through...
Although MIR516A has been reported to be downregulated and act as a tumor suppressor in multiple cancers, its expression potential contribution human bladder cancer (BC) remain unexplored. Unexpectedly, we showed here that was markedly upregulated BC tissues cell lines, while inhibition of attenuated monolayer growth vitro xenograft vivo, accompanied with increased PHLPP2. Further studies able directly bind the 3′-untranslated region PHLPP2 mRNA, which essential for attenuating expression....