A5103192731- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Protein Tyrosine Phosphatases
- RNA Research and Splicing
- Signaling Pathways in Disease
- Glioma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Cancer, Lipids, and Metabolism
- Phytochemical compounds biological activities
- FOXO transcription factor regulation
- Medicinal Plant Pharmacodynamics Research
- Cancer Mechanisms and Therapy
- Ion channel regulation and function
- Plant Disease Resistance and Genetics
- Connective Tissue Growth Factor Research
- Kruppel-like factors research
- Protein Kinase Regulation and GTPase Signaling
- Advanced Breast Cancer Therapies
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
Wenzhou Medical University
2014-2024
Jilin Agricultural University
2022
New York University
2014-2016
Wuhan University
2015
Renmin Hospital of Wuhan University
2015
University of Alabama at Birmingham
2015
Our recent studies found that isorhapontigenin (ISO) showed a significant inhibitory effect on human bladder cancer cell growth, accompanied with cell-cycle G0-G1 arrest as well downregulation of Cyclin D1 expression at transcriptional level via inhibition Sp1 transactivation in cells. In the current study, potential ISO tumor formation has been explored xenograft nude mouse model, and molecular mechanisms underlying anticancer activities have elucidated both vitro vivo. Moreover,...
Glioblastoma (GBM) is the most common malignant brain tumor, and glioma stem cells (GSCs) are considered a major source of treatment resistance for glioblastoma. Identifying new compounds that inhibit growth GSCs understanding their underlying molecular mechanisms therefore important developing novel therapy GBM. We investigated potential inhibitory effect isorhapontigenin (ISO), an anticancer compound identified in our recent investigations, on anchorage-independent patient-derived...
Cheliensisin A (Chel A), as a novel styryl-lactone isolated from Goniothalamus cheliensis Hu, has been demonstrated to have an inhibition of EGF-induced Cl41 cell transformation via stabilizing p53 protein in Chk1-dependent manner, suggesting its chemopreventive activity our previous studies. However, underlying molecular mechanisms not fully characterized yet. In the current study, we found that Chel treatment could increase c-Jun phosphorylation and activation, whereas phosphorylation, by...
Abstract Background Metastasis is the leading cause of death in patients with bladder cancer (BC). However, current available treatments exert little effects on metastatic BC. Moreover, traditional grading and staging have only a limited ability to identify Accumulating evidence indicates that aberrant expression microRNA intimately associated tumor progression. So far, many miRNAs been identified as molecular targets for diagnosis therapy. This study focused role miR‐516a‐5p (miR‐516a)...
The X-linked inhibitor of apoptosis protein (XIAP) contains three N-terminal BIR domains that mediate anti-apoptosis and one C-terminal RING finger domain whose function(s) are not fully defined. Here we show the XIAP strongly inhibits expression p63α, a known tumor suppressor. knockdown in urothelial cells or deletion knockin mice markedly upregulates p63α expression. This RING-mediated downregulation is critical for malignant transformation normal following EGF treatment. We further...
Because bladder cancer (BC) is one of the most common malignant cancers urinary system, identification BC cell growth‐associated effectors great significance. Cyclin‐dependent kinase (CDK)6 a member CDK family cycle‐related proteins and plays an important role in growth. This borne out by fact that CDK6 inhibitor had been approved to treat several types cancers. Nevertheless, underlying molecular mechanisms concerning how regulate expression remains unclear. In present study, it was observed...
Bladder cancer (BC) ranks as the sixth most common in United States and is leading cause of death patients with urinary malignancies. p63 a member p53 family believed to function tumor suppressor human BCs. Our recent studies revealed previously unknown RING XIAP promoting microRNA 4295 (miR-4295) transcription, thereby reducing p63α protein translation enhancing normal urothelial transformation, whereas upregulates hsp70 subsequently activating HSP70/Wasf3/Wave3/matrix metalloproteinase 9...
Skin and feather follicle development are essential processes for goose embryonic growth. Transcriptome next-generation sequencing (NGS) network analyses were performed to improve the genome of Zhedong White discover critical genes, miRNAs, pathways involved in skin morphogenesis. Sequencing output generated 6,002,591,668 8,675,720,319 clean reads from fifteen libraries. There 1234, 3024, 4416, 5326 different genes showing differential expression four stages, E10 vs. E13, E18, E23, E28,...
Abstract Lung cancer remains the leading cause of cancer‐related deaths, with cigarette smoking being most critical factor, linked to nearly 90% lung cases. NNK, a highly carcinogenic nitrosamine found in tobacco, is implicated cancer‐causing effects smoke. Although NNK known mutate or activate certain oncogenes, its potential interaction p27 modulating these currently unexplored. Recent studies have identified specific downregulation human squamous cell carcinoma, contrast adenocarcinoma....
Glioblastoma (GB) is recognized as one of the most aggressive brain tumors, with a median survival 14.6 months. However, there are still some patients whose time was greater than 3 years, and biological reasons behind this clinical phenomenon arouse our research interests. By conducting proteomic analysis on tumor tissues obtained from GB who survived over years compared to those less 1 year, we identified significant upregulation SelK in shorter times. Therefore, hypothesized that may be an...
<div>Abstract<p><b>Purpose:</b> The carcinogenic capacity of B[a]P/B[a]PDE is supported by epidemiologic studies. However, the molecular mechanisms responsible for B[a]P/B[a]PDE-caused lung cancer have not been well investigated. We evaluated here role novel target PHLPP2 in inflammation and carcinogenesis upon exposure.</p><p><b>Experimental Design:</b> used Western blotting, RT-PCR, [<sup>35</sup>S]methionine pulse...
<div>Abstract<p><b>Purpose:</b> The carcinogenic capacity of B[a]P/B[a]PDE is supported by epidemiologic studies. However, the molecular mechanisms responsible for B[a]P/B[a]PDE-caused lung cancer have not been well investigated. We evaluated here role novel target PHLPP2 in inflammation and carcinogenesis upon exposure.</p><p><b>Experimental Design:</b> used Western blotting, RT-PCR, [<sup>35</sup>S]methionine pulse...
Abstract Our previous studies have demonstrated that X-linked inhibitor of apoptosis protein (XIAP) plays a regulatory role in cancer invasion via mediation RhoGDIα SUMOylation at Ser138 colorectal HCT116 cells. However, the alteration/association XIAP invasion, progression, and lung metastasis bladder (BC) as well molecular mechanisms leading to this alteration during BC development not been explored yet. Herein, we found was overexpressed human high grade BCs, metastatic T24T cells, mouse...
Background: Cisplatin-based dualagent chemotherapy is the preferred first-line for non-small cell lung cancer (NSCLC) patients. Moreover, sensitivity of patients to cisplatin associated with good prognosis, so it very important find biomarkers predict cisplatin, which can effectively improve efficacy chemotherapy.Methods: GEO dataset was used analyze relationship between CRTAC1 expression and overall survival in NSCLC treated cisplatin. The effect on lines vitro vivo evaluated by ATP assay,...