A5069090764- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Dialysis and Renal Disease Management
- FOXO transcription factor regulation
- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- Folate and B Vitamins Research
- PI3K/AKT/mTOR signaling in cancer
- Long-Term Effects of COVID-19
- Lipid metabolism and disorders
- Immune Cell Function and Interaction
- Renal Diseases and Glomerulopathies
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Systemic Lupus Erythematosus Research
- Protein Tyrosine Phosphatases
- Bladder and Urothelial Cancer Treatments
- interferon and immune responses
Huazhong University of Science and Technology
2019-2024
Central Hospital of Wuhan
2013-2024
Wuhan University
2015-2024
Renmin Hospital of Wuhan University
2015-2023
Wuhan Donghu University
2023
Zhongnan Hospital of Wuhan University
2020
New York University
2015-2018
University of Alabama at Birmingham
2015
The dysregulation of CD3 + CD8 T lymphocytes, CD16 CD56 NK cells, C1q as well IL-6, along with bacterial coinfection, were important causes exacerbation the patients’ condition and death.
Although our most recent studies have identified Isorhapontigenin (ISO), a novel derivative of stilbene that isolated from Chinese herb Gnetum cleistostachyum, for its inhibition human bladder cancer growth, nothing is known whether ISO possesses an inhibitory effect on invasion. Thus, we addressed this important question in current study and discovered treatment could inhibit mouse-invasive development following carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) exposure vivo We also...
The carcinogenic capacity of B[a]P/B[a]PDE is supported by epidemiologic studies. However, the molecular mechanisms responsible for B[a]P/B[a]PDE-caused lung cancer have not been well investigated. We evaluated here role novel target PHLPP2 in inflammation and carcinogenesis upon exposure.We used Western blotting, RT-PCR, [(35)S]methionine pulse immunohistochemistry staining to determine downregulation following exposure. Both B[a]PDE-induced Beas-2B cell transformation model B[a]P-caused...
Our recent studies found that isorhapontigenin (ISO) showed a significant inhibitory effect on human bladder cancer cell growth, accompanied with cell-cycle G0-G1 arrest as well downregulation of Cyclin D1 expression at transcriptional level via inhibition Sp1 transactivation in cells. In the current study, potential ISO tumor formation has been explored xenograft nude mouse model, and molecular mechanisms underlying anticancer activities have elucidated both vitro vivo. Moreover,...
Abstract Lung cancer has the highest morbidity and mortality among all cancers. Discovery of early diagnostic prognostic biomarkers lung can greatly facilitate survival rate reduce its mortality. In our study, by analyzing Gene Expression Omnibus Oncomine databases, we found a novel potential oncogene uridine‐cytidine kinase 2 ( UCK ), which was overexpressed in tumor tissues compared to adjacent nontumor or normal lung. Then confirmed this finding clinical samples. Specifically, identified...
Glioblastoma (GBM) is the most common malignant brain tumor, and glioma stem cells (GSCs) are considered a major source of treatment resistance for glioblastoma. Identifying new compounds that inhibit growth GSCs understanding their underlying molecular mechanisms therefore important developing novel therapy GBM. We investigated potential inhibitory effect isorhapontigenin (ISO), an anticancer compound identified in our recent investigations, on anchorage-independent patient-derived...
The X-linked inhibitor of apoptosis protein (XIAP) is a well-known potent suppressor and also participates in cancer cell biological behaviors, therefore attracting great attentions as potential antineoplastic therapeutic target for past years. Anti-IAP therapy reported to be closely related epidermal growth factor receptor (EGFR) expression level. However, whether how XIAP modulates EGFR remains largely unknown. Human was knockdown with short-hairpin RNA two different bladder lines, T24T...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related mortality worldwide. The oncogenic role Matrin-3 (MATR3), an a nuclear matrix protein, in HCC remains largely unknown. Here, we document biological function MATR3 based on integrated bioinformatics analysis and functional studies. According to TCGA database, expression was found be positively correlated with clinicopathological characteristics HCC. receiver operating characteristic (ROC) curve Kaplan-Meier (KM)...
Peroxiredoxin 3 (PRDX3) is an abundant and effective enzyme, which aids in the removal of H<sub>2</sub>O<sub>2</sub> mitochondria, thereby inhibiting cell autophagy. PRDX3 a target protein microRNA (miRNA/miR)-383, overexpression has been found to inhibit growth glioma cells. We hypothesized that miR-383 serves antitumor role by oxidative stress during tumor growth. In current study, human U87 cells were transfected with pre-/short hairpin (sh)-PRDX3 vectors mimics/inhibitors. Apoptosis...
Since the end of 2019, dialysis patients have been at risk coronavirus disease 2019 (COVID-19) as well other potential complications. Hence, we sought to describe clinical characteristics with severe acute respiratory syndrome 2 (SARS-CoV-2) infection.We reviewed outcomes, which consisted data extracted from medical records 695 registered Dialysis Center Central Hospital Wuhan January 13th, 2020, February 29th, and performed statistical analysis. According results, there were 447, 227 21...
Our most recent studies demonstrate that miR-137 is downregulated in human bladder cancer (BC) tissues, while treatment of BC cells with isorhapontigenin (ISO) elevates abundance. Since ISO showed a strong inhibition invasive formation the N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced mouse model, elucidation potential biological effect on antagonizing invasion and molecular mechanisms underlying upregulation are very important. Here we discovered ectopic expression led to specific...
Relapse after initial remission reduces renal survival in patients with primary membranous nephropathy (PMN). In this study, we aim to identify risk factors of relapse PMN and construct a model at high early.
The association between serum uric acid (UA) and all-cause cardiovascular-related mortality in hemodialysis (HD) patients is conflicting. We investigated this explored the effect modification of underlying nutritional status, as reflected lean tissue index (LTI) Geriatric Nutritional Risk Index (GNRI), which serve markers muscle mass risk HD patients.
Abstract Our previous studies demonstrated that CCR9 plays an important role in several aspects of T-cell acute lymphoblastic leukemia progression and is a potential therapeutic target. However, the underlying mechanism regulates expression remains incompletely understood. In this study, bioinformatics analysis validation clinical samples revealed lncRNA15691 to be positively correlated with mRNA significantly upregulated CCR9high cell lines. LncRNA15691, previously uncharacterized lncRNA,...
Controversy remains as to whether initiating haemodialysis (HD) with a central venous catheter (CVC) and vascular access conversion are associated the risk of morbidity mortality in incident HD patients.
Background: As pointed out by the recent Kidney Disease Outcomes Quality Initiative Clinical Practice Guideline for Vascular Access, current quality of evidence supporting preoperative vascular anatomy and patient outcomes is suboptimal insufficient to make recommendations. This study assessed arteriovenous fistulas (AVFs) created with different arterial diameters on hospitalization mortality rates in patients undergoing hemodialysis at authors’ center. Methods: Data from 261 who underwent...