A5029648742- Cell death mechanisms and regulation
- Hippo pathway signaling and YAP/TAZ
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Advanced Graph Neural Networks
- Natural Language Processing Techniques
- Modular Robots and Swarm Intelligence
- Developmental Biology and Gene Regulation
- IoT and Edge/Fog Computing
- RNA modifications and cancer
- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Robotics and Automated Systems
- Data Stream Mining Techniques
- Phagocytosis and Immune Regulation
- Speech and dialogue systems
- Nuclear Receptors and Signaling
- COVID-19 diagnosis using AI
- Retinoids in leukemia and cellular processes
- Topic Modeling
- Tensor decomposition and applications
- Protist diversity and phylogeny
- Hedgehog Signaling Pathway Studies
- Blind Source Separation Techniques
- NF-κB Signaling Pathways
Berkeley Systems (United States)
2023
University of California, Berkeley
2023
University of Oxford
2017-2023
Brown University
2019-2023
University of California, Los Angeles
2023
National Institutes of Health
2018-2022
National Institute of Dental and Craniofacial Research
2018-2022
Dublin Business School
2022
Princeton University
2020
Massachusetts Institute of Technology
2017
Mobility, power, and price points often dictate that robots do not have sufficient computing power on board to run contemporary robot algorithms at desired rates. Cloud providers such as AWS, GCP, Azure offer immense increasingly low latency demand, but tapping into from a is non-trivial. We present FogROS2, an open-source platform facilitate cloud fog robotics included in the Robot Operating System 2 (ROS 2) distribution. FogROS2 distinct its predecessor FogROS1 9 ways, including lower...
// Haishan Huang 1,2 , Li Ma 2 Jingxia Yonghui Yu Dongyun Zhang Jinlong Wei Honglei Jin Derek Xu 2,3 Jimin Gao 1 and Chuanshu Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China Nelson Institute Environmental Medicine, New York University Tuxedo, NY, USA 3 Jericho High School, Jericho, NY Correspondence: Huang, email: Gao, Keywords : NF-κB p50, arsenite, c-Myc, protein...
Glioblastoma (GBM) is the most common malignant brain tumor, and glioma stem cells (GSCs) are considered a major source of treatment resistance for glioblastoma. Identifying new compounds that inhibit growth GSCs understanding their underlying molecular mechanisms therefore important developing novel therapy GBM. We investigated potential inhibitory effect isorhapontigenin (ISO), an anticancer compound identified in our recent investigations, on anchorage-independent patient-derived...
Resistance to apoptosis due caspase deregulation is considered one of the main hallmarks cancer. However, discovery novel non-apoptotic functions has revealed unknown intricacies about interplay between these enzymes and tumor progression. To investigate this biological problem, we capitalized on a Drosophila model with human relevance based simultaneous overactivation EGFR JAK/STAT signaling pathways. Our data indicate that widespread activation initiator caspases limits JNK facilitates...
Current evidence has associated caspase activation with the regulation of basic cellular functions without causing apoptosis. Malfunction non-apoptotic activities may contribute to specific neurological disorders, metabolic diseases, autoimmune conditions and cancers. However, our understanding remains limited. Here, we show that prevents intracellular accumulation Patched receptor in autophagosomes subsequent Patched-dependent induction autophagy Drosophila follicular stem cells. These...
Abstract Human cancers often re-express germline factors, yet their mechanistic role in oncogenesis and cancer progression remains unknown. Here we demonstrate that DEAD-box helicase 4 (DDX4), a factor RNA conserved all multicellular organisms, contributes to increased cell motility cisplatin-mediated drug resistance small lung (SCLC) cells. Proteomic analysis suggests DDX4 expression upregulates proteins related DNA repair immune/inflammatory response. Consistent with these trends lines,...
Dendritic arbor morphology influences how neurons receive and integrate extracellular signals. We show that the ELAV/Hu family RNA-binding protein Found in (Fne) is required for space-filling dendrite growth to generate highly branched arbors of Drosophila larval class IV dendritic arborization neurons. Dendrites fne mutant are shorter more dynamic than wild-type, leading decreased coverage. These defects result from both a decrease stable microtubules loss dendrite-substrate interactions...
Recent benchmarks found In-Context Learning (ICL) outperforms both deep learning and tree-based algorithms on small tabular datasets. However, larger datasets, ICL for cannot run without severely compromising performance, due to its quadratic space time complexity w.r.t. dataset size. We propose MIXTUREPFN, which extends nearest-neighbor sampling the state-of-the-art model uses bootstrapping finetune said inference-time dataset. MIXTUREPFN is Condorcet winner across 36 diverse datasets...
The singular value decomposition (SVD) factors a matrix into three separate matrices: two (semi-)unitary matrices whose columns are left/right vectors and one diagonal entries values. Typically, performing SVD on big is taxing due to its compu-tational complexity in the cubic order of dimensions. With advances rapid growth deep learning techniques broad spectrum applications, fundamental question arises: can neural networks learn values matrix? To answer this question, we propose novel...
Embryonic cells and cancer share various cellular characteristics important for their functions. It has been thus proposed that similar mechanisms of regulation may be present in these otherwise disparate cell types. To explore how regulative embryonic are fundamentally different from cancerous cells, we report here a fine balance tumor suppressor protein Retinoblastoma1 (Rb1) germline factor Vasa proper proliferation differentiation the somatic during embryogenesis sea urchin. Rb1 knockdown...
Derek Xu, Shuyan Dong, Changhan Wang, Suyoun Kim, Zhaojiang Lin, Bing Liu, Akshat Shrivastava, Shang-Wen Li, Liang-Hsuan Tseng, Guan-Ting Alexei Baevski, Hung-yi Lee, Yizhou Sun, Wei Wang. Proceedings of the 61st Annual Meeting Association for Computational Linguistics (Volume 1: Long Papers). 2023.
Summary Human cancers often re-express germline factors, yet their mechanistic role in oncogenesis and cancer progression remains unknown. Here we demonstrate that DDX4, a factor RNA helicase conserved all multicellular organisms, contributes to epithelial mesenchyme transition (EMT)-like features cisplatin resistance small cell lung (SCLC) cells. DDX4 depletion H69AR SHP77 lines decreased motility cisplatin, whereas its overexpression increased these features. Proteomic analysis suggests...
Material responses to static and dynamic stimuli, represented as nonlinear curves, are design targets for engineering functionalities like structural support, impact protection, acoustic photonic bandgaps. Three-dimensional metamaterials offer significant tunability due their internal structure, yet existing methods struggle capture complex behavior-to-structure relationships. We present GraphMetaMat, a graph-based framework capable of designing three-dimensional with programmable arbitrary...
Large language models (LLMs) have made significant strides at code generation through improved model design, training, and chain-of-thought. However, prompt-level optimizations remain an important yet under-explored aspect of LLMs for coding. This work focuses on the few-shot examples present in most prompts, offering a systematic study whether improve LLM's coding capabilities, which largest impact, how to select impactful examples. Our offers 2 approaches selecting examples, model-free...
Doublecortin-like kinase1 and 2 (DCLKs) are protein Ser/Thr kinases important for neuronal development. More recently, they also reported to regulate plasticity such as cell proliferation differentiation of stem cells cancer cells, but the details their functions in this biological context still unclear. With an attempt reveal DCLKs regulation, we here used sea urchin embryo that undergoes highly regulative development experimental model. We found both transcripts proteins uniformly present...
Mobility, power, and price points often dictate that robots do not have sufficient computing power on board to run contemporary robot algorithms at desired rates. Cloud providers such as AWS, GCP, Azure offer immense increasingly low latency demand, but tapping into from a is non-trivial. We present FogROS2, an open-source platform facilitate cloud fog robotics included in the Robot Operating System 2 (ROS 2) distribution. FogROS2 distinct its predecessor FogROS1 9 ways, including lower...
Summary Resistance to apoptosis due caspase deregulation is considered one of the main hallmarks cancer. However, discovery novel non-apoptotic functions has revealed unknown intricacies about interplay between these enzymes and tumor progression. To investigate this biological problem, we capitalized on a Drosophila model highly relevant for humans that relies concomitant upregulation EGFR JAK/STAT signaling pathway. Our results indicate widespread activation initiator caspases limits JNK...
A great deal of research has highlighted the role medial prefrontal cortex (mPFC) in encoding motivational value and decision making. Further, alcohol‐induced plasticity mPFC been implicated aberrant alcohol drinking behaviors; however, we have little understanding how neurons are related stimuli real time, what downstream circuits involved. Here, sought to dissect projection‐defined subpopulations within punishment resistant drinking. To allow for vivo recordings neural activity from...
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Resistance to apoptosis due caspase deregulation is considered one of the main hallmarks cancer. However, discovery novel non-apoptotic functions has revealed unknown intricacies about interplay between these enzymes and tumor progression. To investigate this biological problem, we capitalized on a Drosophila model highly relevant for humans that relies concomitant upregulation EGFR JAK/STAT signaling pathway. Our results indicate widespread activation initiator caspases limits JNK...