A5033994290- Cell death mechanisms and regulation
- Alzheimer's disease research and treatments
- Trace Elements in Health
- Carbon and Quantum Dots Applications
- Amyotrophic Lateral Sclerosis Research
- Autophagy in Disease and Therapy
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Connective Tissue Growth Factor Research
- CRISPR and Genetic Engineering
- Heat shock proteins research
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurogenetic and Muscular Disorders Research
- Polyoxometalates: Synthesis and Applications
- Genetics and Neurodevelopmental Disorders
- Pluripotent Stem Cells Research
- Machine Learning in Bioinformatics
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cellular transport and secretion
- Chemical Synthesis and Analysis
- Carcinogens and Genotoxicity Assessment
- Neurological diseases and metabolism
- Immune Cell Function and Interaction
Jilin University
2012-2025
Jilin Medical University
2020
University of Tennessee at Knoxville
2012-2017
Alzheimer's disease is a common progressive neurodegenerative disorder, pathologically characterized by the presence of β-amyloid plaques and neurofibrillary tangles. Current treatment approaches using drugs only alleviate symptoms without curing disease, which serious issue influences quality life patients their caregivers. In recent years, stem cell technology has provided new insights into diseases, including Parkinson's amyotrophic lateral sclerosis. Currently, main sources cells include...
It has been reported that miR-375-3p plays a critical role in numerous diseases. To elucidate its biological function, particularly differential expression and specific mechanisms of action Alzheimer’s disease (AD) small cell lung cancer (SCLC), this study comprehensively explores the associations between target genes both AD SCLC. The focus is specifically on impact progression remodeling tumor microenvironment. We utilized databases such as psRNATarget database STRING database, to...
Chaperonin containing TCP1 subunit 2 (CCT2) is essential in various neurodegenerative diseases, albeit its role the pathogenesis of Alzheimer's disease (AD) remains elusive. This study aimed to evaluate CCT2 disease. First, bioinformatics database analysis revealed that was significantly downregulated patients with and associated autophagic clearance β-amyloid. The 789 differentially expressed genes overlapped AD-group CCT2-low/high group, CCT2-high-associated screened by Pearson...
The clinical prevention, diagnosis, treatment, and drug development of Alzheimer's disease (AD) require urgent detection novel targets methods. Autophagy microglia are significantly associated with the pathogenesis early AD. This study indicated that microRNA-375-3p can inhibit autophagy by promoting mTOR phosphorylation in normal physiological conditions, while promoted enhanced neural repair inhibiting expression presenilin 1 AD pathogenesis. Furthermore, co-treatment rapamycin,...
The γ-secretase complex is composed of at least four components: presenilin 1 or presenilin-2, nicastrin (NCT), anterior pharynx-defective (Aph-1), and enhancer 2. In this study, using knockout cell lines, our data demonstrated that NCT, as well 2, completely blocked γ-secretase-catalyzed processing C-terminal fragment (CTF)α CTFβ, the fragments β-amyloid precursor protein (APP) produced by α-secretase β-secretase cleavages, respectively. Interestingly, in Aph-1-knockout cells, CTFα CTFβ...
Presenilin-1 (PS1) or presenilin-2 (PS2), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin enhancer-2 (Pen-2) have been considered the minimal essential subunits required to form an active γ-secretase complex. Besides PS, which has widely believed function as catalytic subunit of complex, functional roles other in complex remain debatable. In current study, we set out determine role Pen-2 activity. To this end, using knockout cells combination with siRNA...
Presenilin-associated protein (PSAP) was originally identified as a mitochondrial proapoptotic protein. To further explore the apoptotic pathway that involves PSAP, our yeast two-hybrid screen revealed PSAP interacts with death receptor, DR6. DR6 is relatively less common member of receptor family and has been shown to mediate neurotoxicity amyloid-β, mutant SOD1, prion proteins also implicated in regulation immune cell proliferation differentiation. Our previous study showed induces...
TNF α /CHX-induced apoptosis is dependent on caspase-8 activation and regulated by Bcl-2. However, the specific participants precise mechanisms underlying this apoptotic pathway are poorly understood. The proapoptotic proteins Bak Bax—members of Bcl-2 family—are essential for functioning mitochondrial pathway. In study, we used CRISPR/Cas9 system to knockout in human SH-SY5Y cell line determined effects apoptosis. Our data showed that overexpression dramatically prevented apoptosis, then...
Amyotrophic lateral syndrome (ALS) is a progressive degenerative disorder characterized by motor neuron death and axon degeneration. Mitochondrial dysfunction plays key role in the pathogenesis of ALS, mechanism which remains poorly understood. The B-cell lymphoma-2 (Bcl-2) family proteins that control mediate mitochondrial function apoptosis, including pro-apoptotic members Bcl2-Associated X (Bax), are involved ALS development. receptor 6 (DR6) regulates DR6 antibodies can prevent...
Abstract Background One of the most promising treatments for neurodegenerative diseases is stem cell therapy; however, there are still some limitations in treatment Alzheimer's disease (AD), and specific molecular mechanism that affects cognitive function remains unclear. Therefore, it necessary to develop a strategy increase recruitment cells lesion site clinical application. Fe 3 O 4 nanoparticles have good physiological stability, biocompatibility, conducive active uptake cells. Methods...
PDGF, a potent chemoattractant, induces cell migration via MAPK and PI3K/Akt pathways. However, the downstream mediators are still elusive. In particular, role of extracellular is largely unknown. this study, we identified that matricellular protein Cyr61, which de novo synthesized in response to PDGF stimulation, key mediator ERK JNK pathways, independent p38 AKT thereby mediates PDGF‐induced smooth muscle (SMC) migration, but not proliferation. Our results revealed when Cyr61 was newly by...