A5100437270- Toxoplasma gondii Research Studies
- Antimicrobial agents and applications
- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Organometallic Complex Synthesis and Catalysis
- Polymer Surface Interaction Studies
- Parasitic Infections and Diagnostics
- Surface Modification and Superhydrophobicity
- Synthesis and properties of polymers
- Antimicrobial Peptides and Activities
- Polymer composites and self-healing
- Block Copolymer Self-Assembly
- Carbon dioxide utilization in catalysis
- Cyclopropane Reaction Mechanisms
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Photochromic and Fluorescence Chemistry
- Catalytic C–H Functionalization Methods
- Icing and De-icing Technologies
- Petroleum Processing and Analysis
- Electrospun Nanofibers in Biomedical Applications
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Synthetic Organic Chemistry Methods
- Herpesvirus Infections and Treatments
Chinese Academy of Sciences
2012-2025
Jilin University
2016-2025
Zhejiang Sci-Tech University
2022-2025
Suzhou Institute of Nano-tech and Nano-bionics
2025
Shanghai Institute of Optics and Fine Mechanics
2024
Institute of High Energy Physics
2024
Harbin Engineering University
2024
State Key Laboratory of Polymer Physics and Chemistry
2019-2023
Changchun Institute of Applied Chemistry
2014-2023
Southern Medical University
2023
Bacterial infections and multiple encrustations are life-threatening complications in patients implanted with urological devices. Limited by time-consuming procedures substrate dependence, it is difficult to simultaneously prevent the aforementioned complications. Herein, reported design of a salt-triggered chondroitin sulfate complex (CS/Si-N+ ) coating adaptive dissociation, which realizes dual functions antibacterial anti-multiple devices arbitrary shapes. The existence covalent...
The formation of biofilm and thrombus on medical catheters poses a significant life-threatening concern. Hydrophilic anti-biofouling coatings upon catheter surfaces with complex shapes narrow lumens are demonstrated to have the potential in reducing complications. However, their effectiveness is constrained by poor mechanical stability weak substrate adhesion. Herein, novel zwitterionic polyurethane (SUPU) strong long-term developed controlling ratio sulfobetaine-diol ureido-pyrimidinone....
Two-dimensional (2D) platelet structures with uniform dimensions and spatially defined diverse cores are highly sought but still challenging to access. Living crystallization-driven self-assembly (CDSA)-seeded growth enables the creation of 2D core-shell nanomaterials core compositions via sequential epitaxial crystallization block copolymers. Nevertheless, general limitation process strict requirements heteroepitaxial is a major obstacle formation segmented nanoparticles extended...
Two-dimensional, size-tunable, water-dispersible particle micelles with spatially defined chemistries can be obtained by using "living" crystallization-driven self-assembly (CDSA) approach. Nevertheless, a major obstacle of crystalline particles in drug delivery application is the difficulty accessing to cargo within cores. In present work, we design four different types biocompatible two-dimensional platelets poly(ε-caprolactone) (PCL) core, hydrophobic poly(4-vinylprydine) (P4VP) segment,...
The right combination: A catalytic asymmetric multicomponent reaction has been developed in which two stereogenic carbon centers are constructed a single step (see scheme; erythro/threo 90:10, up to 80 % yield, 98 ee). This type of enantioselective three-component generates α,β-dihydroxy acid derivatives good yields and with excellent enantioselectivities. Bn=benzyl. Supporting information for this article is available on the WWW under...
A green, rapid, and efficient method was developed for synthesizing quinazolinone derivatives from substituted 2-halobenzoic acids amidines via microwave-assisted iron-catalyzed cyclization with or without ligand in water (methods B) DMF C D). With these methods, moderate to high yields of the desired products can be obtained even inactive substrates, such as guanidines. To best our knowledge, this is first report on synthesis N-heterocyclic compounds by C–N coupling aqueous media.
Platinum(II) complex [Pt(Me(3)SiC[triple bond]CbpyC[triple bond]CSiMe(3))(C[triple bond]CPh)(2)] (1) with 5,5-bis(trimethylsilylethynyl)-2,2'-bipyridine (Me(3)SiC[triple bond]CSiMe(3)) and phenylacetylene (PhC[triple bond]CH) exhibits unusual luminescence vapochromism to volatile organic compounds (VOCs) including CH(2)Cl(2), CHCl(3), CH(3)I, which is useful for detection of halohydrocarbon one carbon atom molecular weight less than 150. Crystal structural determination 1, 1 x...
A series of highly phosphorescent PtAg2 heterotrinuclear alkynyl complexes with bis(diphenylphosphinomethyl)phenylphosphine (dpmp) were prepared and characterized structurally. The solution phosphorescence various emitting colors is systematically modulated by modifying substituents as well π-conjugated systems in aromatic acetylides. crystals, powders, or films exhibit reversible stimuli-responsive changes upon exposure to vapor MeCN, pyridine, DMF, etc., resulting from perturbation...
Platycodin D (PLD), an effective triterpene saponin extracted from the root of Platycodon grandiflorum, has been reported to have anti-inflammatory effect. The aim this study was investigate effects PLD on LPS-induced inflammation in primary rat microglia cells. production TNF-α, IL-6, and IL-1β were detected by ELISA. expression LXRα, ABCA1, TLR4, NF-κB western blotting.The results showed that significantly inhibited ROS, BV2 also activation. Furthermore, our prevented TLR4 translocation...
Surface-tethered hierarchical polymer brushes find wide applications in the development of antibacterial surfaces due to well-defined spatial distribution and separate but complementary properties different blocks. Existing methods achieve such mainly focused on inorganic material substrates, precluding their practical common medical devices. In this work, a brush system is proposed facilely constructed polymeric substrates via light living graft polymerization. The with micrometer-scale...
Uncontrolled hemorrhage is the leading factor causing death in military trauma and clinical practice usually accompanied with bacterial infection. The fabrication of a functional hemostatic sponge for combating bacteria vital importance. Poly(hexamethylene biguanide) hydrochloride (PHMB) has been shown to have remarkable bactericide effect. However, PHMB after use might toxic effect on humans. Herein, powerful surface-adaptive, on-demand antibacterial sodium alginate/gelatin fabricated by...
Two-dimensional (2D) core–shell nanoparticles have been attracting increasing interest due to their wide applications in materials science. Living crystallization-driven self-assembly (CDSA) is an ambient temperature, seeded growth method of crystallizable block copolymers (BCPs) selective solvents, which has demonstrated be a powerful tool for the creation one-dimensional (1D)/2D nanomaterials with precise control over size and compositions. Nevertheless, development efficient living CDSA...
Abstract Constructing multifunctional surfaces is one of the practical approaches to address catheter‐related multiple complications but generally time‐consuming and substrate‐dependent. Herein, a novel anti‐adhesion, antibacterial, low friction, robustness coating on medical catheters are developed via universal readily scalable method based regulable polyelectrolyte surfactant complex. The complex rapidly assembled in step by electrostatic hydrophobic interactions between organosilicon...
Abstract The dispersion reversible addition‐fragmentation chain transfer (RAFT) polymerization of 4‐vinylpyridine in toluene the presence polystyrene dithiobenzoate (PS‐CTA) macro‐RAFT agent with different length is discussed. RAFT undergoes an initial slow homogeneous and a subsequent fast heterogeneous one. rate dependent on PS‐CTA length, short generally leads to polymerization. induces self‐assembly situ synthesized polystyrene‐ b ‐poly(4‐vinylpyridine) block copolymer into highly...
Neospora caninum is an intracellular protozoan parasite closely related to Toxoplasma gondii that mainly infects canids as the definitive host and cattle intermediate host, resulting in abortion leading financial losses worldwide. Commercial vaccines or drugs are not available for prevention treatment of bovine neosporosis. Knowledge about hallmarks immune response this infection could form basis important strategies. The innate system first responds invading subsequently initiates...
Neospora caninum is an intracellular parasite that causes significant economic losses in cattle industry. Understanding the host resistance mechanisms innate immune response to neosporosis could facilitate exploration of approaches for controlling N. infection. The NLR inflammasome a multiprotein platform cell cytoplasm and plays critical roles against microbes.Neospora caninum-infected wild-type (WT) macrophages Nlrp3 -/- macrophages, inhibitory were used investigate activation its role...
Star poly(<sub>L</sub>-lysine) homo- and copolymers with excellent antimicrobial activity improved biocompatibility can be readily prepared by the combination of ultra-fast ring opening polymerization efficient side-chain modification.
Abstract Ferroelectricity in ultrathin 2D materials has garnered significant attention owing to its potential applications nonvolatile memory, nanoelectronics, and optoelectronics. However, the exploration of ferroelectricity possessing inherent centrosymmetric or mirror symmetry, particularly domain, remains limited. In this study, chemical vapor deposition (CVD) technique is utilized synthesize Bi 2 WO 6 (BWO) nanoflakes, revealing robustly intercorrelated out‐of‐plane (OOP) in‐plane (IP)...