A5101727365- Pesticide Exposure and Toxicity
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Heavy Metal Exposure and Toxicity
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- Heme Oxygenase-1 and Carbon Monoxide
- Hydrogen's biological and therapeutic effects
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Autophagy in Disease and Therapy
- S100 Proteins and Annexins
- Mitochondrial Function and Pathology
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Optical Imaging and Spectroscopy Techniques
- Central Venous Catheters and Hemodialysis
- Photoacoustic and Ultrasonic Imaging
- Vitamin C and Antioxidants Research
- Legionella and Acanthamoeba research
- Microtubule and mitosis dynamics
- Potassium and Related Disorders
- Immunotoxicology and immune responses
- Glutathione Transferases and Polymorphisms
Zhejiang Chinese Medical University
2024
Wenzhou Medical University
2015-2024
Third Xiangya Hospital
2009-2023
Central South University
2011-2023
Yancheng Institute of Technology
2019
Rensselaer Polytechnic Institute
2013-2015
First Affiliated Hospital of Wenzhou Medical University
2015
Wuhan No.9 Hospital
2010
Shenzhen University
2009
University of Pennsylvania
2004-2007
Abstract Celastrol, a pentacyclic tritepene extracted from Tripterygium Wilfordi plant, showing potent liver protection effects on several liver‐related diseases. However, the anti‐inflammatory potential of celastrol in fibrosis and detailed mechanisms remain uncovered. This study was to investigate effect further reveal celastrol‐induced with focus AMPK‐SIRT3 signalling. Celastrol showed ameliorative both activated hepatic stellate cells (HSCs) fibrotic liver. remarkably suppressed...
Chlorpyrifos (CPF) is one of the most widely used organophosphorous insecticides. There are links between CPF exposure and neurological disorders. Mitochondrial damage has been implicated to play a key role in CPF-induced neurotoxicity. Mitophagy, selective autophagic elimination mitochondria, an important mitochondrial quality control mechanism. However, mitophagy neurotoxicity remains unclear. In this study, CPF-caused damage, mechanism on neuroapoptosis were extensively studied by using...
We present a time-resolved fluorescence diffuse optical tomography platform that is based on wide-field structured illumination, single-pixel detection, and hyperspectral acquisition. Two spatial light modulators (digital micro-mirror devices) are employed to generate independently illumination detection patterns, coupled with 16-channel spectrophotometer module capture tomographic data sets. The main system characteristics reported, we demonstrate the feasibility of acquiring dense 4D sets...
Increasing epidemiological and toxicological evidence suggests that pesticides other environmental exposures may be associated with the development of Parkinson's disease (PD). Chlorpyrifos (CPF) is a widely used organophosphorous pesticide developmental neurotoxicity. Its neurotoxicity, notably on monoamine system, exposure CPF induce dopaminergic neuronal injury. We investigated whether neonatal to contributes initiation progression neurotoxicity explored possible underlying mechanisms....
Neonatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of death in neonates with no effective treatments. Recent advancements hydrogen (H 2 ) gas offer promising therapeutic approach for ischemia reperfusion injury; however, the impact this HIE remains subject debate. We assessed effects H on and underlying molecular mechanisms rat model neonatal brain injury (HIBI). inhalation significantly attenuated neuronal effectively improved early neurological outcomes HIBI rats as well...
Chlorpyrifos (CPF), one of organophosphorus pesticides (OPs), is associated with developmental neurotoxicity. Inflammatory response closely related CPF-induced The present study aimed at exploring whether sub-toxic CPF exposure on neonatal rats results in neuroinflammation that mediated by HMGB1/TLR4/NF-κB signaling pathway the amygdala. were subcutaneously injected 5mg/kg for 4 consecutive days (postnatal day 11-14) or without HMGB1 inhibitor, glycyrrhizin. We assessed levels...
Hydrogen peroxide (H2O2) causes cell damage via oxidative stress. Heme oxygenase-1 (HO-1) is an antioxidant enzyme that can protect cardiomyocytes against In this study, we investigated whether the heme precursor 5-aminolevulinic acid (5-ALA) with sodium ferrous citrate (SFC) could from H2O2-induced hypertrophy modulation of HO-1 expression. HL-1 cells pretreated with/without 5-ALA and SFC were exposed to H2O2 induce a cardiomyocyte model. Hypertrophy was evaluated by planar morphometry,...
Helicobacter pylori (H. pylori), a gram-negative pathogen, has been shown to colonize multiple organs and cause various forms of extra-gastrointestinal diseases. The association H. infection with vitamin D status in apparently healthy children remained unclear; therefore, we investigated the relationship between among infants toddlers. In this large cross-sectional study, examination data were collected from January 2013 September 2017 Center for Children’s Health Care. Among these children,...
We studied the incidence of umbilical venous catheterization (UVC)-related infection and pathogens in a neonatal intensive care unit (NICU) China. Patients were grouped into <2000-g UVC or non-UVC groups ≥2001-g groups. Blood culture root skin swab taken following insertion extraction. UVCs removed after 7 days cultures tips performed then. A total 516 patients enrolled. The UVC-related septicemia was 9.5%. per 1000 13.6. No significant difference noted between group groups, number positive...
Hypoxic–ischemic brain damage (HIBD) is one of the leading causes injury in infant with high risk mortality and disability; therefore, it important to explore more feasible effective treatment strategies. Here, we assessed neuroprotective effects different hydrogen inhalation times for HIBD. We induced hypoxia–ischemia Sprague–Dawley rats (postnatal day 7, both sexes), followed by 30, 60, or 90 min. Morphological was Nissl TUNEL staining. Acute inflammation evaluated examining expression...
We describe the computed tomography (CT) imaging features of Ewing sarcoma (EWS)/primitive neuroectodermal tumors (PNETs) arising in anterior and middle mediastinum.The CT findings 6 cases mediastinal EWS/PNETs were reviewed retrospectively. All patients examined with chest radiographs CT, 4 underwent isotope bone scans.The average patient age was 40 years. Results using unenhanced showed lobulated, heterogeneous masses patchy, necrotic foci 5 cases, one small, oval homogenous mass sixth...
Glioblastoma (GB) is recognized as one of the most aggressive brain tumors, with a median survival 14.6 months. However, there are still some patients whose time was greater than 3 years, and biological reasons behind this clinical phenomenon arouse our research interests. By conducting proteomic analysis on tumor tissues obtained from GB who survived over years compared to those less 1 year, we identified significant upregulation SelK in shorter times. Therefore, hypothesized that may be an...
Chlorpyrifos (CPF) is a widely used organophosphorus pesticide. Increasing evidence has shown that exposure to CPF in early life might induce neurodevelopmental disorders, but the pathogenesis remains uncertain. Synaptic plasticity plays crucial role neurodevelopment. This study aimed investigate effect of on synaptic hippocampal neurons and establish cellular mechanism underlying these effects. Using CPF-exposed rat primary model, we analyzed impact morphology, expression level presynaptic...
Little is known about pesticide exposure risks for children in rural areas China, many of whom have been left behind by migrant workers. To survey caregivers China and assess their use disposal methods, the measures were used to protect perceptions adverse effects pesticides on children's health. Three or four villages each Xinhua, Gongan Sansui Counties selected random cluster sampling. The main aged 1–6 years surveyed face-to-face interviews. questionnaire was adapted from World Health...
In China, a 9-year-old boy was transferred to the hospital with fever, vomiting, and headache. The disease rapidly deteriorated into vague consciousness. Applying conventional clinical examinations such as blood cerebrospinal fluid (CSF) tests, diagnosis of bacterial meningoencephalitis first drawn, expectant treatments were adopted immediately. However, symptoms did not alleviate, adversely, this died 3 days after admission. Considering skeptical points duration, unknown infectious bacteria...