A5055040028- Hydrogen's biological and therapeutic effects
- Biochemical effects in animals
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Treatment and Pharmacology
- Anesthesia and Neurotoxicity Research
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Electron Spin Resonance Studies
- Medical and Biological Ozone Research
- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Cancer therapeutics and mechanisms
- Rheumatoid Arthritis Research and Therapies
- Synthesis and Biological Activity
- Dietary Effects on Health
- Natural product bioactivities and synthesis
- Gut microbiota and health
- Marine Sponges and Natural Products
- Pharmacological Effects of Natural Compounds
- Earthquake and Disaster Impact Studies
- Synthesis and Reactions of Organic Compounds
- Urban and spatial planning
- Plant chemical constituents analysis
- Synthetic Organic Chemistry Methods
- Infant Nutrition and Health
Musashino University
2023
Keio University
2020-2023
Osaka University
2020
National Center For Child Health and Development
2020
Kansai Medical University
2020
Keio University Shonan Fujisawa
2020
Osaka Dental University
2015
Loyola University Medical Center
2006
Tohoku University
2005
Central Research Laboratories (United Kingdom)
1977-2001
Hydrogen exerts beneficial effects in disease animal models of ischemia-reperfusion injury as well inflammatory and neurological disease. Additionally, molecular hydrogen is useful for various novel medical therapeutic applications the clinical setting. In present study, concentration rat blood tissue was estimated. Wistar rats were orally administered super-rich water (HSRW), intraperitoneal intravenous administration saline (HSRS), inhalation gas. A new method determining then applied...
ABSTRACT Bacterial translocation is a major cause of multiple organ dysfunction syndrome in critical illness, and its management an important therapeutic strategy. In this study, we focused on the key factors responsible for bacterial including intestinal microbiome investigated impact molecular hydrogen therapy as countermeasure against murine model sepsis. The experimental protocols were divided into sham, saline treatment (control), (H2) groups. H2 group, 15 mL/kg hydrogen-rich (7 ppm)...
Neonatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of death in neonates with no effective treatments. Recent advancements hydrogen (H 2 ) gas offer promising therapeutic approach for ischemia reperfusion injury; however, the impact this HIE remains subject debate. We assessed effects H on and underlying molecular mechanisms rat model neonatal brain injury (HIBI). inhalation significantly attenuated neuronal effectively improved early neurological outcomes HIBI rats as well...
Background/Objective: The endothelial glycocalyx is a gel-like layer on the vascular surface that crucial for maintaining homeostasis. Massive bleeding leads to shedding of glycocalyx, which can lead leakage during fluid administration. Recently, beneficial effect hydrogen inhalation in treatment hemorrhagic shock has been reported. However, efficacy hydrogen-rich saline protecting remains unclear. In this study, we investigated effects degeneration. Methods: Rats under general anesthesia...
The mRNA expression of inflammatory cytokines in the HRW group was lower than CSAA group. reversed hepatocyte apoptosis as well hepatic inflammation and fibrosis NASH specimens. Molecular hydrogen inhibits LPS-induced via an HO-1/IL-10-independent pathway. improved steatosis + Sirt1 induction by molecular HO-1/AMPK/PPARα/PPARγ pathway suppresses palmitate-mediated abnormal fat metabolism.
Molecular hydrogen (H2) is clinically administered; however, in some hospitals, H2 given to patients without consideration of its safe use. In the present study, we prepared convenient and devices for drinking super-saturated water, intravenous drip infusion H2-rich saline, inhalation gas. order provide useful information researchers using these devices, changes concentration were studied. Our experimental results should contribute advance non-clinical clinical research medicine.
Fatty liver has lower tolerance against ischemia-reperfusion (I/R) injury in operations, including transplantation. Seeking to ameliorate following I/R fatty liver, we examined the protective effect of hydrogen (H2) saline on a methionine and choline-deficient plus high fat (MCDHF) diet-induced mouse model. Saline containing 7 ppm H2 was administrated during process I/R. Livers were obtained analyzed. Primary hepatocytes Kupffer cells (KCs) from subjected hypoxia/reoxygenation....
Hydrogen (H2) is promising as an energy source for the next generation. Medical applications using H2 gas can be also considered a clean and economical technology. Since based on electrolysis of water production has potential to expand medical applications, technology been developed in order safely dilute it supply living body by inhalation, respectively. inert molecule which scavenge highly active oxidants including hydroxyl radical (·OH) peroxynitrite (ONOO−), convert them into water....
Although intensity-modulated radiation therapy (IMRT) has been developed as an alternative to conventional radiotherapy, reducing bone marrow damage is limited. Thus, a novel technology needed further mitigate IMRT-induced damage. Molecular hydrogen (H 2 ) was recently reported preventive and therapeutic antioxidant that selectively scavenges hydroxyl radical (·OH) peroxynitrite (ONOO – ). This observational study aimed examine whether H gas treatment improves in cancer patients. The...
In order to elucidate the mechanism of antihypertensive action dried bonito (katsuobushi), we compared effects extracts with those captopril, an angiotensin I-converting enzyme (ACE) inhibitor, on aorta preparations isolated from rats. Dried (3×10−4 3×10−3 g/ml) more potently relaxed contractions induced by norepinephrine (10−7 M) than KCl (55.9 mM). (3×10−3 slightly inhibited 10−7 M I-induced contractions. contrast, captopril (10−8 did not affect norepinephrine- or 55.9 mM KCl-induced...
Lactobacillus casei I-5 isolated from an alcohol fermentation broth enhanced immunity and prevented pathogenic infection as a probiotic. Mice fed with cells for 11 days prior to intraperitoneal challenge Escherichia coli Juhl exhibited high survival rate compared the control group. Rats 10 significantly increased phagocytosis of peritoneal macrophages. In cell culture system employing macrophages rats, administration activated NF-kappaB stimulated by LPS. It also LPS-stimulated IL-12...
Journal Article A Comparative Electron Microscopic Study of Aclacinomycin and Adriamycin Cardiotoxicities in Rabbits Hamsters Get access Takashi WAKABAYASHI, WAKABAYASHI *Department Pathology, Nagoya City University Medical SchoolMizuho-ku, Nagoya, 467 Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Toshikazu OKI, OKI **Central Research Laboratory Sanraku-Ocean Co., Ltd.Kanagawa, 251 Hiroshi TONE, TONE Shinichi HIRANO, HIRANO Kentaro OMORI Microscopy,...
Hypoxic–ischemic brain damage (HIBD) is one of the leading causes injury in infant with high risk mortality and disability; therefore, it important to explore more feasible effective treatment strategies. Here, we assessed neuroprotective effects different hydrogen inhalation times for HIBD. We induced hypoxia–ischemia Sprague–Dawley rats (postnatal day 7, both sexes), followed by 30, 60, or 90 min. Morphological was Nissl TUNEL staining. Acute inflammation evaluated examining expression...