A5017146720- Transplantation: Methods and Outcomes
- Lung Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
- Myasthenia Gravis and Thymoma
- Polyomavirus and related diseases
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Immune cells in cancer
- Pulmonary Hypertension Research and Treatments
- Peptidase Inhibition and Analysis
- Chemokine receptors and signaling
- Surgical Simulation and Training
- Trauma Management and Diagnosis
- Occupational and environmental lung diseases
- Congenital Diaphragmatic Hernia Studies
- Pneumothorax, Barotrauma, Emphysema
- Medical Imaging and Analysis
- Lung Cancer Research Studies
- Pituitary Gland Disorders and Treatments
Nagoya University
2019-2025
Nagoya University Hospital
2020-2025
Kyoto University
2015-2023
Kyoto University Hospital
2016-2023
Japan Cancer Society
2022
Okayama University
2022
Tokyo Medical University
2022
Highlights•HPS2-iPSCs and cHPS2-iPSCs were generated from HPS2 patient fibroblasts•Anti-NaPi2b antibody was useful for isolating AT2 cells human lung AOs•The enlargement abnormal distribution of LBs observed in HPS2-AOs•Impaired surfactant secretion demonstrated HPS2-AOsSummaryIt has been challenging to generate vitro models alveolar diseases, as the stable culture type 2 (AT2) difficult. Methods generating expanding derived induced pluripotent stem (iPSCs) have established are expected be...
We have reported loss of SMAD4 promotes expression CCL15 from colorectal cancer to recruit CCR1+ myeloid cells through the CCL15-CCR1 axis, which contributes invasion and liver metastasis. However, molecular mechanism lung metastasis is yet be elucidated. Our purpose determine whether similar involved in cancer.In a mouse model, we examined could affect metastatic activity axis. immunohistochemically analyzed SMAD4, CCL15, CCR1 with 107 clinical specimens metastases. also characterized using...
Three-dimensional computed tomography (3D-CT) technologies have been developed and refined over time. Recently, high-speed high-quality 3D-CT also introduced to the field of thoracic surgery. The purpose this manuscript is demonstrate several examples these in various scenarios surgery.A newly-developed 3D image analysis software system was used Kyoto University Hospital. Simulation and/or navigation were performed using technology surgeries.Preoperative simulation most patients undergoing...
Abstract Lung cancer treatment is difficult owing to chemoresistance. Hypoxia‐inducible factor 1 ( HIF ‐1) and ‐1‐induced glycolysis are correlated with chemoresistance; however, this not evident in lung cancer. We investigated the effect of ‐1 α carbonic anhydrase IX CAIX ), a transmembrane protein neutralizing intracellular acidosis, on chemoresistance prognosis patients after induction chemoradiotherapy. Associations , glucose transporter GLUT 1), were using A549 cells under normoxia or...
Malignant pleural mesothelioma (MPM) has extremely limited treatment despite a poor prognosis. Moreover, molecular targeted therapy for MPM not yet been implemented; thus, new is highly desirable. Near-infrared photoimmunotherapy (NIR-PIT) recently developed cancer that combines the specificity of antibodies targeting tumors with toxicity induced by photoabsorber after exposure to NIR-light. In this study, we phototherapy podoplanin (PDPN) use both NIR-PIT and an anti-PDPN antibody, NZ-1. An...
BackgroundSmall cell lung cancer (SCLC) has a poor prognosis, and its treatment options are limited. Delta-like protein 3 (DLL3) is expressed specifically in SCLC considered promising therapeutic target for patients with this disease. Rovalpituzumab tesirine (Rova-T) was the first antibody-drug conjugate targeting DLL3. Although Rova-T development unfortunately terminated, DLL3 remains an ideal SCLC. Near infrared photoimmunotherapy (NIR-PIT) new form of that employs antibody-photosensitiser...
Combined induced pluripotent stem cells and airway-on-a-chip establish the global axis of planar cell polarity in patient-derived airway sheet.
Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment (TME). Most CAFs shape TME toward immunosuppressive milieu and attenuate efficacy immune checkpoint blockade (ICB) therapy. However, detailed mechanism how heterogeneous regulate response to ICB therapy has not been defined. Here, we show that a recently defined CAF subset characterized by expression Meflin, glycosylphosphatidylinositol-anchored protein marker mesenchymal stromal/stem cells, is...
Abstract Objectives Chest wall infiltration in primary lung cancer affects the surgical and therapeutic strategies. This study evaluates efficacy of chest vessel involvement subpleural (CWVI) on ultra-high-resolution CT (UHR-CT) for detecting invasion. Materials methods A retrospective analysis cases with confirmed pleural invasion was conducted from November 2019 to April 2022 . Seventy-seven patients (mean ± standard deviation age 70 8 years, 64 males) who underwent preoperative...
There are few papers on three-dimensional (3D) images of the lungs using non-enhanced computed tomography (CT). This study aimed to investigate accuracy 3D CT. The included 10 consecutive cases for each lung lobe, totalling 50 between March and December 2022. patients had both contrast-enhanced CT taken within 2 months before surgery. A image analysis system (SYNAPSE VINCENT) was used obtain pulmonary artery (PA), vein (PV), bronchus (Br). automatically generated based CTs, which were then...
Peripheral helper T (Tph) cells, together with plasma are the major pathogenic lymphocytes in synovium rheumatoid arthritis (RA). However, whether these cells involved RA-associated lung and/or airway disease is unknown. Tph sputum were analyzed by flow cytometry and compared those synovial fluid tissue. Forty RA subjects for whom induced could be collected along several clinical parameters; severity was assessed using Disease Activity Score 28 joints (DAS28). Lung chest computed tomography...
The aim of the study was to describe specific characteristics patients with microscopic residual disease (R1) after surgical resection for non-small cell lung cancer and evaluate effect postoperative therapy in R1 patients. We retrospectively reviewed clinical data 3,296 Enrolled were divided into two groups: those who received (PT) did not receive (NPT). A total 52 enrolled. Of those, 27 (51.9%) underwent extended resections addition standard surgery, 37 assigned PT group 15 NPT group....
ABSTRACT In cases of thymoma with autoimmune disease, extended thymectomy may improve disease symptoms and medication effects. Myasthenia gravis (MG) is the most common complication, but Stiff‐Person syndrome (SPS) rare, there are few reports surgery. present case, we performed robot‐assisted on a 74‐year‐old man who had MG SPS. At 6 months after surgery, his SPS improved dose prednisolone been reduced, confirming that surgical treatment contributed to control. Thus far, only two studies...
Mesothelioma is characterized by the inactivation of tumor suppressor genes, with frequent mutations in neurofibromin 2 (NF2), BRCA1-associated protein 1 (BAP1), and cyclin-dependent kinase inhibitor 2A (CDKN2A). These lead to disruptions Hippo signaling pathway histone methylation, promoting growth. NF2 result Merlin loss, leading uncontrolled cell proliferation, whereas BAP1 impair chromatin remodeling hinder DNA damage repair. Emerging molecular targets mesothelioma include mesothelin...
ObjectiveUse of 3-dimensional computed tomography for preoperative and intraoperative simulation has been introduced in the field thoracic surgery. However, provides only static simulation, which is a significant limitation surgical simulation. Dynamic reflecting deformation lung, not developed. The aim this study was to develop novel system that generates dynamic images based on patient-specific data.MethodsWe developed an original software, Resection Process Map, anatomic pulmonary...
Radiological pleuroparenchymal fibroelastosis (PPFE) lesion is characterized by pleural thickening with associated signs of subpleural fibrosis on high-resolution computed tomography (HRCT). This study evaluated the clinical significance radiological PPFE as an isolated finding or other interstitial lung diseases (ILDs) in patients having fibrotic ILDs and registered for cadaveric transplantation (LT).This retrospective included 118 ILD LT. HRCT was assessed. The impact features...