A5010613587- Gamma-ray bursts and supernovae
- Astronomical Observations and Instrumentation
- Astrophysical Phenomena and Observations
- SAS software applications and methods
- Pulsars and Gravitational Waves Research
- Statistical and numerical algorithms
- Micro and Nano Robotics
- Solar and Space Plasma Dynamics
- Astronomy and Astrophysical Research
- Cellular Mechanics and Interactions
- Astrophysics and Cosmic Phenomena
- Particle Detector Development and Performance
- Cell Image Analysis Techniques
- 3D Printing in Biomedical Research
- Earthquake Detection and Analysis
- Ionosphere and magnetosphere dynamics
- Protist diversity and phylogeny
- Microtubule and mitosis dynamics
- Receptor Mechanisms and Signaling
- Particle Accelerators and Free-Electron Lasers
- Atmospheric and Environmental Gas Dynamics
- Chromosomal and Genetic Variations
- Diffusion and Search Dynamics
- Cystic Fibrosis Research Advances
- Atomic and Subatomic Physics Research
The University of Tokyo
2020-2025
Tokyo University of the Arts
2019-2024
Hiroshima University
2008-2019
Combined induced pluripotent stem cells and airway-on-a-chip establish the global axis of planar cell polarity in patient-derived airway sheet.
Tissue growth and deformation result from the combined effects of various cellular events, including cell shape change, rearrangement, division, death. Resolving integrating these events is essential for understanding coordination tissue-scale by individual behaviors that are critical morphogenesis, wound healing, other collective phenomena. For epithelial tissues composed tightly connected cells, texture tensor method provides a unified framework quantifying tissue strains tracking cells in...
Abstract Tissues consist of cells with different molecular and/or mechanical properties. Measuring the forces and stresses in mixed-cell populations is essential for understanding mechanisms by which tissue development, homeostasis, disease emerge from cooperation distinct cell types. However, many previous studies have primarily focused their measurements on dissociated or aggregates a single-cell type, leaving mechanics largely unexplored. In present study, we aimed to elucidate influence...
Multiciliated cells (MCCs) in tracheas generate mucociliary clearance through coordinated ciliary beating. Apical microtubules (MTs) play a crucial role this process by organizing the planar cell polarity (PCP)–dependent orientation of basal bodies (BBs), for which underlying molecular basis remains elusive. Herein, we found that deficiency Daple, dishevelled-associating protein, tracheal MCCs impaired polarized apical MTs without affecting core PCP proteins, causing significant defects BB...
The paracellular barrier function of tight junctions (TJs) in epithelial cell sheets is robustly maintained against mechanical fluctuations, by molecular mechanisms that are poorly understood. Vinculin an adaptor a mechanosensory complex at the adherens junction. Here, we generated vinculin KO Eph4 cells and analyzed their confluent cell-sheet properties. We found dispensable for basic TJ structural integrity larger solutes. However, indispensable ions. In addition, TJs stochastically showed...
<h2>Abstract</h2> Complex networks of interacting molecular components living cells are responsible for many important processes, such as signal processing and transduction. An challenge is to understand how the individual properties these interactions biochemical transformations determine system-level biological functions. Here, we address issue accuracy transduction performed by a bacterial chemotaxis system. The sensitivity bacteria chemoattractant gradient has been measured...
Synchronous and directed ciliary beating in trachea allows transport ejection of virus dust from the body. This function depends on coordinated configuration basal bodies (root cilia) apical cell membrane. However, mechanism for their formation remains unknown. In this study, we show that polarity microtubule bundles plays a significant role organization bodies. A mathematical model incorporating has been formulated which provides coherent explanation is able to reproduce experimental...
Tissues consist of cells with different molecular and/or mechanical properties. Measuring the forces and stresses in mixed-cell populations is essential for understanding mechanisms by which tissue development, homeostasis, disease emerge from cooperation distinct cell types. However, many previous studies have primarily focused their measurements on dissociated or aggregates a single-cell type, leaving mechanics largely unexplored. In present study, we aimed to elucidate influence...