A5077039092- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Salivary Gland Disorders and Functions
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Boron Compounds in Chemistry
- Oral Health Pathology and Treatment
- Head and Neck Cancer Studies
- Tumors and Oncological Cases
- Cancer Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Bone Tumor Diagnosis and Treatments
- S100 Proteins and Annexins
- Cancer Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Nuclear Physics and Applications
- Ear and Head Tumors
- Cancer, Hypoxia, and Metabolism
- Virology and Viral Diseases
- Proteoglycans and glycosaminoglycans research
- Polyamine Metabolism and Applications
- Cell Adhesion Molecules Research
- Osteomyelitis and Bone Disorders Research
Osaka University
2015-2024
Osaka Dental University
1977-2019
Suita Tokushukai Hospital
2015
California Wellness Foundation
2013
Saiseikaisenri Hospital
2013
National Medical Research Center of Dentistry and Maxillofacial Surgery
2007
Tokushima University
1990-2001
Northwestern University
1989-1991
The neoplastic epithelial duct cells human salivary gland (HSG) and myoepithelial pleomorphic adenoma (HPA) established from were examined by the immunoperoxidase method for presence of specific antigens such as carcioembryonic antigen (CEA), S-100 protein, secretory component (SC), lactoferrin (LF), myosin. Isolation their morphologic features reported previously. Consequently, CEA, SC, LF in HSG was demonstrated. HPA identified to express reactive anti-S-100 anti-myosin anti-CEA sera...
The tumor microbiome, a relatively new research field, affects progression through several mechanisms. Cancer Microbiome Atlas (TCMA) database was recently published. In the present study, we used TCMA and Genome examined microbiome profiling in head neck squamous cell carcinoma (HNSCC), role of intratumoral microbiota prognosis HNSCC patients, differentially expressed genes cells relation to specific bacterial infections. We investigated 18 microbes at genus level that differed between...
Periodontal disease is a risk factor for head and neck squamous cell carcinoma (HNSCC), Porphyromonas gingivalis, major periodontal pathogen, has been identified as specific potentially independent microbial that increases the of cancer mortality. Gene expression in HNSCC due to P. gingivalis infection how changes gene affect prognosis patients are not clarified. When was cultured with cells, it efficiently adhered these cells enhanced their invasive ability. A transcriptome analysis...
A neoplastic epithelial cell line was established from nude mice tumors grown after transplantation of surgical specimens a human parotid gland adenocarcinoma. This line, which had ultrastructure similarities to salivary intercalated duct cells, found by immunohistochemical techniques contain amylase, but myosin not detected. Ultrastructurally, cells an intermediate type between ductal and myoepithelial were in the transplanted tumors. Moreover, expression addition presence amylase detected...
Oral squamous cell carcinoma (OSCC) is the sixth most common cancer and frequently metastasizes to cervical lymph nodes, leading poor survival of patients with OSCC. However, mechanism node metastasis not fully understood. To clarify molecular underlying OSCC regional highly metastatic fluorescent labeled line SAS-LM3 was successfully established allowing us monitor progression metastases in a non-invasive manner. tumors showed increased lymphangiogenesis elevated expression VEGF-C, potent...
Safingol, L- threo-dihydrosphingosine, induces cell death in human oral squamous carcinoma (SCC) cells through an endonuclease G (endoG) -mediated pathway. We herein determined whether safingol induced apoptosis and autophagy SCC cells. Safingol apoptotic a dose-dependent manner. In safingol-treated cells, microtubule-associated protein 1 light chain 3 (LC3)-I was changed to LC3-II the cytoplasmic expression of LC3, amount acidic vesicular organelles (AVOs) stained by acridine orange...
The main objective of this study was to evaluate the biological behavior Hydroxyapatite (HAp)/agarose and calcium carbonate (CaCO3)/agarose composite gels by an alternate soaking process used for treatment surgically produced bone defects in rat cranium. We designed following four groups: (i) HAp (HAp/agarose gel), (ii) CaCO3 (CaCO3/agarose (iii) Agarose (bare agarose (iv) Defect (no filling materials). subdivided into two application types as a (I) Homogenized Group (homogenized materials)...
Sphingosine kinase 1 (SphK1) overexpressed in head and neck squamous cell carcinoma (SCC) regulates tumor growth. The effects of PF-543, a specific SphK1 inhibitor, on human SCC cells were examined. proportion viable after PF-543 treatment decreased time- dose-dependent manner, death occurred SphK1-expressing cells. Flow cytometry analysis revealed that induced both necrosis apoptosis. also granular accumulation LC3 conversion from LC3-I to LC3-II, which was blocked by autophagy inhibitors,...
To identify stem cells in salivary glands, label-retaining (LRCs) were established rat submandibular glands. Developing and regenerating glands labeled with bromodeoxyuridine (BrdU). cause gland regeneration, the injured by duct obstruction. BrdU LRCs observed all parenchymal structures except for acinus of during regeneration. Among these LRCs, a few, but not many, expressed neither keratin18 (K18; an acinar/duct cell marker) nor alpha-smooth muscle actin (alphaSMA; myoepithelial marker),...
The activation of Wnt signaling has been reported in many types squamous cell carcinoma. In this study, using human oral carcinoma (OSCC) cells with different metastatic potential, we investigated the involvement metastasis. Further, aimed to elucidate characteristic biological features related high potential and identify new target molecules for suppression OSCC lymph node We compared SAS-Venus (SAS expressing green fluorescent protein) SAS-LM8, which is a highly line derived from by vivo...