A5102934884- Foot and Ankle Surgery
- Antifungal resistance and susceptibility
- Tendon Structure and Treatment
- Neurological Complications and Syndromes
- Lower Extremity Biomechanics and Pathologies
- Neuroendocrine regulation and behavior
- Reproductive biology and impacts on aquatic species
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Orthopedic Surgery and Rehabilitation
- Aquaculture Nutrition and Growth
- Parasitic Diseases Research and Treatment
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Metabolism and Genetic Disorders
- Cystic Fibrosis Research Advances
- Vitamin C and Antioxidants Research
- Antibiotics Pharmacokinetics and Efficacy
- Poisoning and overdose treatments
- Folate and B Vitamins Research
- Medication Adherence and Compliance
- Chronic Kidney Disease and Diabetes
- Organ Transplantation Techniques and Outcomes
- Sports injuries and prevention
- Drug-Induced Adverse Reactions
Nagasaki University Hospital
2017-2025
Sasebo City General Hospital
2021-2025
Nagasaki University
2012-2025
Kyoto first Red Cross hospital
2024
Kogakuin University
2022
Chiba University
2021
Hiroshima University
2018-2020
Gifu University
2016-2019
Tottori University
2019
Osaka University
2002-2015
An 82-year-old woman undergoing peritoneal dialysis (PD) presented to our hospital with cloudy PD effluent since four days. The leukocyte count in the was elevated 2900/μL, and patient diagnosed PD-related peritonitis. Treatment cefazolin ceftazidime initiated; however, did not improve. Culture of revealed presence Streptococcus gordonii. switched ampicillin monotherapy; when still normalize, catheter removed for management refractory peritonitis, which then cured. S. gordonii can form...
Abstract Liposomal amphotericin B (L-AMB) is a broad-spectrum antifungal drug that used to treat fungal infections. However, clinical evidence of its use in patients with renal failure limited. Here, we aimed identify factors associated acute kidney injury (AKI) administered L-AMB. We retrospectively utilized combination Diagnosis Procedure Combination data and laboratory obtained from hospitals throughout Japan between April 2008 January 2018. In total, 507 L-AMB were identified. After...
Abstract Although polypharmacy is common among patients on hemodialysis (HD), its association with prognosis remains unclear. This study aimed to elucidate the between number of prescribed medicines and all-cause mortality in HD, accounting for essential (i.e., antihypertensives, antidiabetic medicines, statins) non-essential medicines. We evaluated 339 who underwent maintenance HD at Nagasaki Renal Center July 2011 June 2012 followed up until 2021. After adjusting patient characteristics,...
Retrograde drilling (RD) is generally used for treating osteochondral lesion of the talus (OLT) with a stable fragment and nearly normal articular cartilage surface. Previous studies that included participants various ages have reported good clinical results. This study aimed to clarify outcomes RD OLT in juvenile patients whose bone-forming ability physical activity might affect healing process.This retrospective 8 who underwent (5 boys 3 girls, mean age 14.9 years, follow-up 2 7 medial 1...
Secretory leukocyte protease inhibitor (SLPI) is a protein found in various fluids, including parotid secretions, cervical mucus, seminal plasma and ascites, potent of human elastase activity. The objective the study was 2-fold, to evaluate (i) presence SLPI Fallopian tube, (ii) effect on acrosome reaction sperm.Western blot analysis revealed that detected as 12 kDa band isthmus, ampulla infundibulum tube. Immunohistochemistry using an anti-SLPI polyclonal antibody positive staining...
Background: In the evaluation of osteochondral lesions talar dome (OLT), bone marrow (BML) are commonly observed in subchondral on magnetic resonance imaging (MRI). However, significance BML, such as histology overlying cartilage, is still unclear. The purpose this study was to investigate relationship between BML and cartilage degeneration OLT. Methods: Thirty-three ankles with OLT were included study. All underwent CT MRI had operative treatment. divided into 2 groups, depending presence...
Background: Large osteochondral lesions of the talus (OLT) with good articular cartilage can be fixed by using bioabsorbable pins. These pins have various advantages but they adverse effects such as foreign body inflammation. This negative impact on subchondral bone seen marrow edema (BME) magnetic resonance imaging (MRI). The purpose this study was to investigate course change in BME MRI, including osteolytic around OLT treated pin fixation. Methods: comprised 13 ankles 12 patients, who...
Chronic ankle instability (CAI) induces osteoarthritis (OA) by inflicting abnormal stresses on the medial gutter. It is important to detect early OA change and explore factors likely induce OA. The purpose of this study was evaluate subchondral bone in gutter CAI using computed tomography (CT) scans.Thirty-five ankles with (CAI group) 35 without (control were included. region interest (ROI) CT axial images set tibia talus. Hounsfield unit (HU) ROIs measured corrected HU fibula same slice....
Acute kidney injury (AKI) often develops during the administration of liposomal amphotericin B (L-AMB), a broad-spectrum antifungal drug. However, clinical recovery approaches for AKI patients administered L-AMB are not well established. This retrospective analysis used data obtained from hospitals throughout Japan. was defined as ≥ 1.5-fold increase within 7 days or ≥0.3 mg/dL 2 in serum creatinine. return to creatinine levels below equal those recorded before onset. Ninety were assessed...
Abstract Vasotocin (VT) and isotocin (IT) are teleost neurohypophysial hormones produced by neurosecretory neurons in the magnocellular part of preoptic nucleus (PM) hypothalamus. Several previous studies indicated that involved reproductive behavior. The changes expression VT IT genes were thus studied an situ hybridization technique immunohistochemical avidin-biotin-complex method pre-spawning chum salmon (Oncorhynchus keta). Male female fish caught at Atsuta, mouth Ishikari Bay, Chitose,...
High serum calcium levels should be avoided in patients on hemodialysis (HD) because they can induce cardiovascular diseases and worsen the patient's prognosis. In contrast, low prognosis of with cerebral hemorrhage general population. So far, whether HD are associated remains unknown. This study aimed to reveal association between HD, including in-hospital death, volume hematoma, onset hemorrhage.
We investigated the efficacy of supplementing diet with choline or betaine in ameliorating lipid accumulation induced by vitamin B6 (B6) deficiency rat liver. Male Wistar rats were fed a control, B6-deficient, choline-supplemented (2, 4, 6 g bitartrate/kg diet) B6-deficient betaine-supplemented (1, 2, 4 anhydrous/kg for 35 d; all diets contained 9 L-methionine (Met)/kg diet. Choline supplementation attenuated liver deposition and restored plasma profiles to control levels. These treatments...
BACKGROUND Endocan is expressed in vascular endothelial cells, and its expression enhanced following injury via inflammatory cytokines. Subsequently, endocan secreted into the circulation. Thus, serum levels are considered a marker of injury. However, to best our knowledge, no data on peritoneal dialysis (PD) patients available. MATERIAL AND METHODS This study included 21 PD who underwent equilibration test (PET) more than once between 2011 2015. Serum samples were collected from each...
Effects of the coastal oceanographic conditions on sexual maturation, salinity tolerance, and expression vasotocin (VT) gene in homing chum salmon, Oncorhynchus keta, were studied by four years fieldwork transfer experiments. In 1992 1993, fish sampled at three sites along their migratory pathway Sanriku coast, Japan. experiments 1994 1995, captured seawater (SW) environment transferred to SW or freshwater (FW) aquaria 1 4 days later. The distribution cold warm currents, which governs...
Subepithelial deposits are observed in rare adult IgA nephropathy (IgAN) cases and a key diagnostic finding IgA-dominant infection-related glomerulonephritis (IgA-IRGN). Sometimes, it is difficult to distinguish IgA-IRGN from IgAN without precise clinical history. We hypothesized that some might be diagnosed as with subepithelial (IgAN-SD) aimed clarify the significance of patients IgAN. examined 464 at Nagasaki University Hospital affiliated hospitals between 1996 2013. The differences...
Despite previous studies suggesting that choline and betaine ameliorate lipid accumulation in rat livers, the relative effectiveness of two nutrients is unclear. We examined efficacy dietary supplementation with or ameliorating induced by vitamin B6 (B6) deficiency liver. Male Wistar rats were fed control, B6-deficient, choline-supplemented betaine-supplemented both B6-deficient diets (all containing 9 g l-methionine (Met)/kg) for 35 d. Two experiments performed, i.e., one using 17 mmol/kg...
The effect of statin on hemodialysis patients is controversial. Although previous large-scale studies did not clarify its in this population, recent suggest that statins could be useful reducing the risk cardiovascular events and all-cause mortality specific groups undergoing hemodialysis. aforementioned included a small percentage Asians, few have investigated effects Asians Thus, we benefits maintenance at single center Japan. We obtained demographic, clinical, data all who underwent...