A5016008286- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Sphingolipid Metabolism and Signaling
- Ion channel regulation and function
- Pharmacological Receptor Mechanisms and Effects
- Animal Nutrition and Physiology
- Cancer, Stress, Anesthesia, and Immune Response
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Pharmacological Effects of Natural Compounds
- Nerve injury and regeneration
- Botulinum Toxin and Related Neurological Disorders
- Neurotransmitter Receptor Influence on Behavior
- Chemical Synthesis and Analysis
- Protein Kinase Regulation and GTPase Signaling
- Protein Hydrolysis and Bioactive Peptides
- S100 Proteins and Annexins
- Cell death mechanisms and regulation
- Neuroendocrine regulation and behavior
- Hereditary Neurological Disorders
- Hypothalamic control of reproductive hormones
Institute of Vegetable and Floriculture Science
2018-2025
Gifu University
2007-2025
Kyoto University
1994-2024
Research Institute for Production Development
2021-2024
National Defense Medical Center
2022-2024
University of Tsukuba Hospital
2024
National Defense Medical College
2024
Nagasaki University
2014-2023
University of Tsukuba
2023
Shibuya (Japan)
2022
Oral administration of the perilla leaf extract (PLE) to mice inhibits inflammation, allergic response, and tumor necrosis factor-α production. We also found that PLE suppressed (TNF-α) production in vitro. Using inhibitory activity TNF-α vitro as index for isolation, we searched active constituents from isolated luteolin, rosmarinic acid caffeic components. Among compounds, only luteolin showed vivo activity: inhibition serum production, arachidonic acid-induced ear edema,...
The dentate gyrus of the hippocampus, generating new cells throughout life, is essential for normal recognition memory performance. Reduction brain-derived neurotrophic factor (BDNF) in this structure impairs its functions. To elucidate association between BDNF levels and hippocampal neurogenesis, we first conducted a search compounds that stimulate endogenous production granule neurons. Among ion channel modulators tested, riluzole, neuroprotective agent with anticonvulsant properties...
Peripheral nerve injury causes neuropathic pain, which is characterized by the paradoxical sensations of positive and negative symptoms. Clinically, signs are frequently observed; however, their underlying molecular mechanisms largely unknown. Dysfunction C-fibers assumed to underlie symptoms accompanied long-lasting downregulation Na v 1.8 sodium channel μ-opioid receptor (MOP) in dorsal root ganglion (DRG). In present study, we found that upregulates neuron-restrictive silencer factor...
In a new mouse model for generalized pain syndrome, including fibromyalgia, which used intermittent cold stress (ICS), bilateral allodynia in the hindpaw was observed that lasted more than 12 days; thermal hyperalgesia 15 days. During constant (CCS), mice showed only transient allodynia. A female prevalence ICS-induced gonadectomized but not gonad intact mice. Systemic gabapentin complete anti-allodynic effects ICS at one-tenth dose injury-induced neuropathic model, and central long-lasting...
Here, we investigated the mechanism of antihyperalgesic effect capsaicin cream in nerve injury-induced neuropathic pain model mice. In naive mice, application onto footpad caused no significant changes thermal latency contrast to severe hyperalgesia induced by a ointment. On other hand, 3 h before test concentration dependently reversed both and mechanical observed after partial sciatic injury algogenic-induced nociceptive flexion (ANF) test, 0.1% mice blocked intraplantar (i.pl.)...
Paclitaxel (Taxol) is a widely used chemotherapeutic agent in the treatment of several tumors. However, its use often associated with generation peripheral neuropathic pain expressed as mechanical allodynia and thermal hyperalgesia. The molecular mechanism behind this debilitating side effect obscure, efficient drugs for prevention are required. We sought to clarify cellular changes involved nociceptor types underlying paclitaxel-induced test an alleviating gabapentin murine model pain....
Recently, we reported that lysophosphatidic acid (LPA) induces long-lasting mechanical allodynia and thermal hyperalgesia as well demyelination upregulation of pain-related proteins through one its cognate receptors, LPA 1 . In addition, mice lacking the receptor gene ( lpa -/- mice) lost these nerve injury-induced neuropathic pain behaviors phenomena. However, since did not exhibit any effects on basal nociceptive threshold, it is possible machineries are initiated by via defined...
Lysophosphatidic acid (LPA) is a bioactive lipid that binds to group of cell surface G protein-coupled receptors (LPA 1-6 [LPA1-6 ]) and has been implicated as an important mediator angiogenesis, inflammation, cancer growth. This study was undertaken analyze the effects LPA1 on development arthritis.Expression LPA synovial tissue analyzed by immunohistochemistry quantitative reverse transcription-polymerase chain reaction. The abrogation collagen-induced arthritis (CIA) were evaluated using...
Background and Purpose Hypoesthesia is a clinical feature of neuropathic pain. The partly explained by the evidence epigenetic repression Na v 1.8 sodium channel in dorsal root ganglion ( DRG ). Experimental Approach We investigated possibility trichostatin A TSA ), valproic acid VPA ) suberoylanilide hydroxamic SAHA to reverse unique C ‐fibre sensitivity observed following partial ligation sciatic nerve mice. Key Results Nerve injury‐induced down‐regulation ‐fibre‐related hypoesthesia were...
The tolerance and dependence after chronic medication with morphine are thought to be representative models for studying the plasticity, including remodeling of neuronal networks. To test hypothesis that changes in plasticity observed opioid or derived from increased activity anti-opioid nociceptin system, effects treatments were examined using receptor knock-out (NOR(-/-)) mice a novel nonpeptidic NOR antagonist, J-113397, which shows specific potent antagonist vitro [(35)S]GTPgammaS...