A5083717544- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Chemokine receptors and signaling
- Monoclonal and Polyclonal Antibodies Research
- Inflammasome and immune disorders
- Cancer Immunotherapy and Biomarkers
- Sphingolipid Metabolism and Signaling
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Complement system in diseases
- Immune Cell Function and Interaction
- Ocular Diseases and Behçet’s Syndrome
- Platelet Disorders and Treatments
- Autoimmune Bullous Skin Diseases
- Peptidase Inhibition and Analysis
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Atherosclerosis and Cardiovascular Diseases
- Kawasaki Disease and Coronary Complications
- Rheumatoid Arthritis Research and Therapies
- Chronic Lymphocytic Leukemia Research
- Histiocytic Disorders and Treatments
St. Marianna University School of Medicine
2022-2025
Nippon Medical School
2020-2024
Massachusetts General Hospital
2015-2019
Harvard University
2014-2019
Tokyo Medical and Dental University
2011-2019
Tokyo Women's Medical University
2018
Metabolism and Renal Physiology
2018
Cell Biologics (United States)
2018
Center for Rheumatology
2013
Nagoya City University
2013
Herpes simplex virus (HSV)-1 encephalitis has significant morbidity partly because of an over-exuberant immune response characterized by leukocyte infiltration into the brain and increased blood-brain barrier (BBB) permeability. Determining role specific subsets factors that mediate their recruitment is critical to developing targeted therapies. In a murine model, we find chemokines CXCL1 CCL2 are induced in following HSV-1 infection. Ccr2 (CCL2 receptor)-deficient mice have reduced monocyte...
Randomised-controlled trials have recently proven the efficacy of interleukin (IL)-6 receptor antagonist tocilizumab (TCZ) in giant cell arteritis (GCA). However, mechanism action IL-6 blockade this disease is unknown. Moreover, role regulatory T (Treg) cells pathogenesis GCA remains underexplored. Given plasticity Tregs and importance their biology, we hypothesised that TCZ might modulate Treg response GCA. We therefore characterised compartment patients with treated TCZ.We classified 41...
Excessive activation of immune cells by environmental factors, such as infection or individual genetic risk, causes various autoimmune diseases. Streptococcus species are gram-positive bacteria that colonize the nasopharynx, respiratory tract, gastrointestinal genitourinary and skin. Group A (GAS) cause symptoms, ranging from mild infections, tonsillitis pharyngitis, to serious necrotizing fasciitis streptococcal toxic shock syndrome. The contribution GAS infections several diseases,...
Abstract Introduction Chemerin is a chemotactic agonist identified as ligand for ChemR23 that expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the expression of chemerin in synovium rheumatoid arthritis (RA) patients stimulatory effects fibroblast-like synoviocytes (FLSs) from RA patients. Methods was ascertained by immunohistochemistry Western blot analysis. cultured FLSs ELISA. determined immunocytochemistry Cytokine production measured FLS cell motility...
The deposition of immune complexes (IC) in tissues induces a "type III hypersensitivity" that results tissue damage and underlies the pathogenesis many autoimmune diseases. neutrophil is first cell recruited into sites IC plays critical role shaping overall response. However, mechanism by which initiate propagate infiltration not known. Here, using intravital multiphoton joint imaging IC-induced arthritis live mice, we found complement C5a receptor (C5aR) was key initiator adhesion on...
Some of cannabinoids, which are chemical compounds contained in marijuana, immunosuppressive. One the receptors, CB receptor 1 (CB1), is expressed predominantly by cells central nervous system, whereas 2 (CB2) primarily immune cells. Theoretically, selective CB2 agonists should be devoid psychoactive effects. In this study, we investigated therapeutic effects a agonist on arthritis. The expression was analyzed with immunohistochemistry and Western blotting. Interleukin (IL)-6, matrix...
Lysophosphatidic acid (LPA) is a bioactive lipid that binds to group of cell surface G protein-coupled receptors (LPA 1-6 [LPA1-6 ]) and has been implicated as an important mediator angiogenesis, inflammation, cancer growth. This study was undertaken analyze the effects LPA1 on development arthritis.Expression LPA synovial tissue analyzed by immunohistochemistry quantitative reverse transcription-polymerase chain reaction. The abrogation collagen-induced arthritis (CIA) were evaluated using...
Environmental triggers, including those from pathogens, are thought to play an important role in triggering autoimmune diseases, such as vasculitis, genetically susceptible individuals. The mechanism by which activation of the innate immune system contributes vessel-specific autoimmunity vasculitis is not known. Systemic administration Candida albicans water-soluble extract (CAWS) induces aortic root and coronary arteries mice that mimics human Kawasaki disease. We found Dectin-2 signaling...
The interaction between CXCL12 and its receptor, CXCR4, in the synovium of patients with rheumatoid arthritis (RA) is important for local inflammatory cell recruitment, angiogenesis, cytokine production. CXCR7 was recently identified as an alternative receptor CXCL12. We undertook this study to analyze expression RA pathogenic role CXCL12/CXCR7 pathway RA.CXCR7 synovial tissue analyzed using immunohistochemistry, while CXCR4 on human umbilical vein endothelial cells (HUVECs) examined...
Malaria remains one of the world's most significant human infectious diseases and cerebral malaria (CM) is its deadly complication. CM pathogenesis incompletely understood, hindering development therapeutics to prevent this lethal Elevated levels chemokine CXCL10 are a biomarker for CM, receptor CXCR3 required experimental (ECM) in mice, but their role has remained unclear. Using multiphoton intravital microscopy, receptor- ligand-deficient mice bone marrow chimeric we demonstrate key...
Biological drugs are effective in patients with rheumatoid arthritis (RA), but increase severe infections. The CC chemokine receptor (CCR) 9 antagonist was for Crohn's disease without critical adverse effects including infections clinical trials. present study carried out to explore the pathogenic roles of (C-C motif) ligand (CCL) 25 and its receptor, CCR9, autoimmune if CCR9 could be a new treatment RA.CCL25 expression examined immunohistochemistry Western blotting. Concentration...
C5aR2 transports C5a into the blood vessel lumen to initiate neutrophil arrest in a murine model of arthritis.
Background: Immune checkpoint inhibitors (ICIs) can induce immune-related adverse events (irAEs). Liquid biomarkers to predict irAE occurrence are urgently needed. We previously developed an ELISA system specifically detect soluble PD-L1 (sPD-L1) with PD-1-binding capacity (bsPD-L1). Here, we investigated the relationship between sPD-L1 and bsPD-L1 in gastric cancer (GC) non-small cell lung (NSCLC) treated PD-1/PD-L1 blockade their association irAEs. Methods: examined sPD-L1, bsPD-L1, matrix...
Abstract Chemokine receptors typically have multiple ligands. Consequently, treatment with a blocking antibody against single chemokine is expected to be insufficient for efficacy. Here we show single-chain antibodies can engineered broad crossreactivity toward human and mouse proinflammatory ELR + CXC chemokines. The molecules recognize functional epitopes of chemokines inhibit neutrophil activation ex vivo. Furthermore, an albumin fusion the most crossreactive prevents reverses...
Abstract Introduction Lysophosphatidic acid (LPA) is a bioactive lipid that binds to G protein-coupled receptors (LPA 1-6 ). Recently, we reported abrogation of LPA receptor 1 ) ameliorated murine collagen-induced arthritis, probably via inhibition inflammatory cell migration, Th17 differentiation and osteoclastogenesis. In this study, examined the importance LPA-LPA axis in proliferation, cytokine/chemokine production lymphocyte transmigration fibroblast-like synoviocytes (FLSs) obtained...
The tumor microenvironment (TME) impacts the therapeutic efficacy of immune checkpoint inhibitors (ICIs). No liquid biomarkers are available to evaluate TME heterogeneity. Here, we investigated clinical significance PD-1-binding soluble PD-L1 (bsPD-L1) in gastric cancer (GC) patients and non-small cell lung (NSCLC) treated with PD-1/PD-L1 blockade.
Vasculitis is characterized by leukocyte infiltration in the vessel walls, with destructive damage to mural structures. Retinoids are compounds that bind retinoic acid receptors and exert biologic activities similar those of vitamin A, including modulatory effects on cell proliferation differentiation. This study was undertaken examine therapeutic a synthetic retinoid, Am80, murine model vasculitis induced Candida albicans water-soluble fraction (CAWS).Vasculitis BALB/c mice intraperitoneal...