A5101444611- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Liver Diseases and Immunity
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Pharmacy and Medical Practices
- Systemic Lupus Erythematosus Research
- Pharmacological Effects of Natural Compounds
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Pathogenesis and Treatment of Hiccups
- Lung Cancer Treatments and Mutations
- Hepatitis Viruses Studies and Epidemiology
- Drug-Induced Hepatotoxicity and Protection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Bowel Disease
- Microscopic Colitis
Tokai University
2008-2025
Chiba University
2015-2024
Tokyo Women's Medical University
2000-2024
Tokyo Women's Medical University Yachiyo Medical Center
2013-2024
Chiba University Hospital
2017-2022
The Japanese Society of Gastroenterological Surgery
2022
Tohoku University
2021
Yokohama National University
2016-2020
University Gastroenterology
2020
Ulvac (Japan)
2019
To investigate the hepatitis B virus (HBV) genotype-related differences in progression of liver disease, 585 patients with chronic HBV infection including 258 histologically verified disease (CLD) and 74 hepatocellular carcinoma (HCC) were examined. The mean ages both advanced fibrosis (F3 or F4) HCC significantly older genotype than C (P =.018, P =.024, respectively). Both e antigen (HBeAg) negativity rate at biopsy cumulative HBe seroconversion CLD higher <.01, =.022, Multivariate analysis...
Although gene expression profiling is a promising diagnostic technique to determine the tissue of origin for patients with cancer unknown primary site (CUP), no clinical trial has evaluated yet site-specific therapy directed by this approach compared empirical chemotherapy. We therefore performed randomized study assess whether such improves outcome chemotherapy in previously untreated CUP.Comprehensive was microarray analysis, and an established algorithm applied predict tumor origin....
The present study aimed to assess the efficacy and safety of lenvatinib verify possibility for expanded indication from REFLECT trial in patients with advanced hepatocellular carcinoma (HCC) real-world practice, primarily focusing on population that was excluded trial.We retrospectively collected data HCC who were administered 7 institutions Japan.Of 152 patients, 95 57 received first-line second- or later-line systemic therapies, respectively. median progression-free survival Child-Pugh...
Functional dyspepsia (FD) is a common disease but there no established treatment. Rikkunshito traditional Japanese medicine that widely used for treating upper gastrointestinal symptoms and its effect on ghrelin of great interest. The aim this study was to investigate the rikkunshito levels acylated (AG) in patients with FD.This paralleled, randomized controlled trial. Patients were treated either (group R) or domperidone D) 4 weeks. overall change dyspeptic evaluated by GSRS...
Abstract Background To fill the data gap between clinical trials and real-world settings, this study assessed overall effectiveness safety of nivolumab in patients with head neck cancer (HNC) during Japanese practice. Methods This was a multicenter, retrospective recurrent or metastatic HNC who received for first time July December 2017. Data on use, effectiveness, were extracted from patient medical records. Results Overall, 256 enrolled study. The median duration treatment 72.5 days,...
The prognosis of patients with advanced hepatocellular carcinoma (HCC) is expected to improve as multiple molecular target agents (MTAs) are now available. However, the impact availability sequential MTAs has not been fully verified yet.We retrospectively collected data on whole clinical course 877 who received any first-line systemic therapy for HCC between June 2009 and March 2019. study population was divided into 3 groups according date MTA administration (period 1: 2009-2012, n = 267;...
There is no standard posttreatment for patients with advanced hepatocellular carcinoma (HCC) in whom lenvatinib therapy has failed. This study aimed to investigate rates of migration after and explore candidates second-line agents the failed therapy.We retrospectively collected data on HCC who received as first-line agent 7 institutions.Overall survival progression-free (PFS) 178 were 13.3 months (95% confidence interval [CI], 11.5-15.2) 6.7 CI, 5.6-7.8), respectively. Sixty-nine 151 (45.7%)...
Background. Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) has been shown to modulate multiple cellular processes, including apoptosis. The aim of this study was assess the effects HCV NS5A on apoptosis induced by Toll-like receptor (TLR) 4 ligand, lipopolysaccharide (LPS).
Acute liver failure (ALF) is a worldwide problem despite its rare incidence because of extremely high mortality. There are no beneficial therapies except for emergency transplantation ALF. However, in Japan where the shortage donor livers still remains, other than must be further investigated patients with Our aim was to elucidate efficacy high-dose corticosteroid (CS) decreasing enzyme levels early stage ALF.Thirty-one consecutive Japanese viral ALF were prospectively examined their...
We retrospectively reviewed 413 recipients with hematologic malignancies who underwent hematopoietic stem cell transplantation (HSCT) between June 1986 and March 2013. Recipients antibody to hepatitis B core antigen (anti-HBc) and/or surface (anti-HBs) were regarded as experiencing previous virus (HBV) infection. Clinical data of these from medical records. defined ≥1 log IU/mL increase in serum HBV DNA nadir reactivation (HBsAg)-positive recipients, also or re-appearance HBsAg...
OBJECTIVES: The pathophysiology of functional dyspepsia (FD) is not fully understood. Impaired duodenal mucosal integrity characterized by increased permeability and/or low-grade inflammation was reported as potentially important etiologies. We aimed to determine the utility a recently developed simple catheterization method measure admittance (MA), inverse impedance, for evaluation in patients with FD. METHODS: conducted two prospective studies. In first study, MA 23 subjects determined...
Abstract FGF19/FGFR4 autocrine signaling is one of the main targets for multi-kinase inhibitors (MKIs). However, molecular mechanisms underlying in antitumor effects to MKIs hepatocellular carcinoma (HCC) remain unclear. In this study, impact FGFR4/ERK inhibition on HCC following MKI treatment was analyzed vitro and vivo assays. Serum FGF19 patients treated using MKIs, such as sorafenib (n = 173) lenvatinib 40), measured by enzyme-linked immunosorbent assay. Lenvatinib strongly inhibited...
Abstract Background The shortage of instructors and time to teach traditional Japanese (Kampo) medicine (KM) limits students’ understanding its usefulness. We developed an e-learning course solve this problem. Methods Kampo consists 12 lessons on 10 essential formulas with related formulas, proper prescriptions, dosages, adverse reactions, followed by review questions. After the course, each student answers additional clinical questions correctly, they are awarded a certificate completion....
Self-expandable metallic stent (SEMS) placement is useful for patients with poor oral intake caused by esophageal stricture attributable to malignancy. In this study, we examined the usefulness of SEMS as a palliative treatment and evaluated prognostic factors. Patients who underwent at three regional base hospitals from December 2007 June 2023 were included in study. Of 73 patients, 57 after excluding 16 whom postoperative was possible placement. Median survival 67 days (mean, 96 ± days)....
Comprehensive analysis of the changes in gene expression during liver regeneration was carried out by using an in-house microarray composed 2,304 distinct mouse cDNA clones. Mice were subjected to partial two-thirds hepatectomy, and mRNA levels monitored up 48 h. Of genes analyzed, 496 showed measurable at all time points after hepatectomy. 317 up- or down-regulated 2-fold more least one point classified into eight clusters based on their patterns. With a stringent cut-off value ±2 S.D., 68...