A5005082363- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Pharmacology and Obesity Treatment
- Plant-based Medicinal Research
- Tryptophan and brain disorders
- Healthcare and Venom Research
- Complementary and Alternative Medicine Studies
- Olfactory and Sensory Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacy and Medical Practices
- Stress Responses and Cortisol
- Vestibular and auditory disorders
- Pathogenesis and Treatment of Hiccups
- Mycobacterium research and diagnosis
- Cancer Treatment and Pharmacology
- Traditional Chinese Medicine Analysis
- Pain Mechanisms and Treatments
- Enhanced Recovery After Surgery
- Drug-Induced Hepatotoxicity and Protection
- Glaucoma and retinal disorders
- Cardiac Structural Anomalies and Repair
- Ginseng Biological Effects and Applications
- Medicinal Plants and Bioactive Compounds
- Metabolomics and Mass Spectrometry Studies
- Pain Management and Placebo Effect
Kitasato University
2016-2025
Tokyo Medical University
2020
Tokyo Medical University Hospital
2020
Keio University
1996-2015
Keio University Hospital
2012
St. Marianna University School of Medicine
2012
Saiseikai Central Hospital
2012
Kitasato Institute Hospital
2006-2008
It is generally accepted that the primary pharmacological activities and adverse effects of Ephedra Herb are caused by ephedrine alkaloids. Interestingly, our research shows also has alkaloid-independent actions, such as c-MET inhibitory activity. This study describes preparation an alkaloids-free extract (EFE) ion-exchange column chromatography, well in vitro vivo evaluation its actions toxicity. We confirmed EFE suppressed hepatocyte growth factor (HGF)-induced cancer cell motility...
Abstract Background The shortage of instructors and time to teach traditional Japanese (Kampo) medicine (KM) limits students’ understanding its usefulness. We developed an e-learning course solve this problem. Methods Kampo consists 12 lessons on 10 essential formulas with related formulas, proper prescriptions, dosages, adverse reactions, followed by review questions. After the course, each student answers additional clinical questions correctly, they are awarded a certificate completion....
Several Ephedra Herb-containing Kampo medicines are common initial treatments for various infections; however, the ephedrine alkaloids in Herb can cause side effects by stimulating adrenergic receptors. Accordingly, an alkaloids-free Extract (EFE) has been developed. This study aimed to evaluate whether EFE be used effectively and safely patients with mild coronavirus disease 2019 (COVID-19). We randomized COVID-19 receive equivalent 6 g of per day or a placebo 14 days. The primary efficacy...
The evaluation of tongue colour has been an important approach to examine human health in Kampo medicine (traditional Japanese medicine) because the change may suggest physical or mental disorders. Several quantification methods have published objectify clinical information among East Asian countries. However, reliable analysis results test persons are limited a lack quantitative colour. We aimed use advances digital imaging processing quantify and verify data diagnosis by characterising...
We report for the first time that ephedrine alkaloids-free Ephedra Herb extract (EFE) directly inhibits replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and addition EFE to culture medium before viral infection reduces virus titers supernatant SARS-CoV-2, including those variant strains, by more than 99%, 24 h after infection. The macromolecule condensed-tannin, which is main active ingredient responsible anticancer, pain suppression, anti-influenza...
Objective: The purpose of this clinical trial was to assess the efficacy goshuyuto, a typical Kampo formula, in preventing episodes headache chronic patients.Research design and methods: Because treatment target formula is decided on basis different that Western medicine, we first selected patients belonging subgroup responded goshuyuto before conducting usual randomized controlled trial. During stage 1, subjects were instructed orally consume for 4 weeks. Only those judged as responders...
Kososan, a Kampo (traditional Japanese herbal) medicine, has been used for the therapy of depressive mood in humans. However, evidence antidepressant efficacy kososan and potential mechanisms are lacking. Recently, it recognized that stress triggers neuroinflammation suppresses adult neurogenesis, leading to depression anxiety. Here, we examined whether extract affected social behavior mice exposed chronic defeat (CSDS), an animal model prolonged psychosocial stress, induced by CSDS. In CSDS...
Ephedrine alkaloids-free Ephedra Herb extract (EFE) has been developed to eliminate the adverse effects caused by ephedrine alkaloid-induced sympathetic hyperactivation. Previously, we reported that EFE possesses analgesic, anti-influenza, and cancer metastatic inhibitory at comparable levels of (EHE). However, it not yet demonstrated is free from known side EHE, such as excitation, insomnia, arrhythmias. In this study, incidence these was compared between mice administered EHE those EFE....
In tongue diagnosis, colour information of body has kept valuable regarding the state disease and its correlation with internal organs. Qualitatively, practitioners may have difficulty in their judgement due to instable lighting condition naked eye’s ability capture exact distribution on especially multicolour substance. To overcome this ambiguity, paper presents a two-stage tongue’s classification based support vector machine (SVM) whose vectors are reduced by our proposed <mml:math...
The analgesic effect of Ephedra Herb (EH) is believed to be derived from the anti-inflammatory action pseudoephedrine (Pse). We recently reported that ephedrine alkaloids-free EH extract (EFE) attenuates formalin-induced pain same level as achieved by (EHE), which suggests may not due alkaloids (EAs). To examine contribution EAs EH, mice were injected with formalin induce a biphasic reaction (first phase, 0-5 min; second 10-45 min) at various time points after oral administration following...
Previously, we reported that the c-Met inhibitory effect of Ephedra Herb extract (EHE) is derived from ingredients besides ephedrine alkaloids. Moreover, analgesic and anti-influenza activities EHE alkaloids-free (EFE) have been recently. In this study, examined fractions containing kinase activity with EFE, elucidated structural characteristics active fractions. Significant was observed in 30, 40, 50% methanol (MeOH) eluate obtained water using Diaion HP-20 column chromatography. Similarly,...
Kampo medicines containing Ephedra Herb (EH) such as eppikajutsubuto and makyoyokukanto are used to treat myalgia, arthralgia, rheumatism. The analgesic effects of these attributed the anti-inflammatory action EH. However, molecular mechanism effect EH remains be clarified. In this study, extract (EHE) on transient receptor potential vanilloid 1 (TRPV1), a nonselective ligand-gated cation channel, which plays an essential role in nociception sensory neurons, were investigated using...
The objective of this study was to determine the efficacy Go-rei-San (GRS), a Kampo medicine, in treatment postoperative nausea, vomiting, or both nausea and vomiting (PONV).The randomized, controlled, single-blind two groups adult female patients who were scheduled undergo benign gynecological laparoscopic surgery under general anesthesia. Patients each group possessed an American Society Anesthesiologists physical status 1 (normal, healthy patient) 2 (patient with mild systemic disease)....
Ephedra Herb is an important crude drug; it used in various Traditional Japanese Medicine (Kampo) formulations. Its significant pharmacological effects have been believed to be attributed ephedrine and pseudoephedrine, which sometimes induce adverse effects. On the other hand, has reported that some of these are not dependent on or pseudoephedrine. Ephedrine alkaloids‐free extract newly developed. It analgesic, anti‐influenza, antimetastatic This clinical trial was aimed at verifying...
Aging-induced neuroinflammation, also known as neuroinflammaging, plays a pivotal role in emotional disturbances, including depression and anxiety, older individuals, thereby leading to cognitive dysfunction. Although numerous studies have focused on therapeutic strategies for impairment little research has been performed treating its preceding disturbances. Here, we examined whether Kampo formulas (kososan [KS], nobiletin-rich kososan [NKS], hachimijiogan [HJG]) can ameliorate aging-induced...
背景:モデル・コア・カリキュラムに「和漢薬を概説できる」の一項目が追加され,漢方医学教育が採用された。目的:2007年から漢方医学教育は全国80の医学部全てで行われている。その現状を把握し,大学における漢方医学教育の問題点や,今後漢方専門医等学会に課せられた問題のヒントを得ることを目的に,アンケート調査を行なった。方法:日本東洋医学会渉外委員会は,全国80大学の漢方教育に関するアンケート調査を郵送で実施した。結果:80施設中67施設から回答(回収率83.8%)を得た。漢方医学が医療にとって必要(91%),教育成果の評価のために試験実施(77%),教員養成を行っている(46%)などの結果を得た。結論:卒前の漢方医学教育カリキュラムの充実と,標準化,臨床実習の整備が必要である。今後は卒後教育の確立が必要と考えられた。
We previously reported that Daikenchuto (DKT), a gastrointestinal prokinetic Japanese herbal (Kampo) medicine used for the treatment of postoperative ileus (POI), has characteristic potent anti-inflammatory activity. This effect may be partly mediated by activation α7 nicotinic acetylcholine receptor (nAChR). In this study, we identified specific herbs in DKT induce action.The components were individually administered orally to each mouse four times before and after intestinal manipulation...
Identifying different species of the genus Atractylodes which are commonly used in Chinese and Japanese traditional medicine, using chromatographic approaches can be difficult. 1H NMR metabolic profiling DNA-authenticated, archived rhizomes was performed for genetic chemical evaluation. The ITS region nuclear rDNA sequenced five species, A. japonica, macrocephala, lancea, chinensis, koreana. Our samples had nucleotide sequences as previously reported, except that part lancea cultivated Japan...
Apricot and Peach Kernels are commercial crude drugs used in many formulas of traditional Japanese medicine, Kampo. Although their applications quite different, it is difficult to distinguish them using conventional methods such as HPLC. The study aimed at near-infrared (NIR) metabolic profiling discriminate (Armeniacae Semen Persicae Semen) collected from markets. A fast, simple, non-destructive, robust NIR measurement kernel surface with no sample pre-treatment was achieved situ. Principal...
2000年から2009年の9年間に当研究所にて,漢方薬による薬物性肝障害と診断した21症例について検討した。平均年齢55.2 ± 13.4歳で,男性5例,女性16例であった。服用3カ月以内には17例(81.0%)が発症していた。発症時,無症状が11例(52.4%)であり,肝細胞障害型と混合型が共に9例(42.9%)であった。起因漢方薬としては19例と9割以上が黄芩を含む処方であった。DLST施行例は5例のみであり,方剤陽性は1例のみであった。治療としては,原因薬の中止のみで肝障害の軽減および肝機能の正常化を認めたのが18例(85.7%)で他2例は同処方去黄芩にて正常化を認めた。今後,特に黄芩を含む処方の場合に無症状でも,薬物性肝障害の早期発見のために3カ月以内の採血が必要と考える。