A5002230786- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Vascular Malformations Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Carbohydrate Chemistry and Synthesis
- PI3K/AKT/mTOR signaling in cancer
- Virus-based gene therapy research
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Neurological disorders and treatments
- Glycosylation and Glycoproteins Research
- Synthesis and biological activity
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Neurosurgical Procedures and Complications
- Lysosomal Storage Disorders Research
- Blood disorders and treatments
- Ubiquitin and proteasome pathways
- Intracerebral and Subarachnoid Hemorrhage Research
Tokyo Medical and Dental University
2015-2024
The University of Tokyo
1989-2024
Tokyo Medical and Dental University Hospital
2023
Oita University Hospital
2018
Kyoto University
2018
Tokyo Metropolitan Komagome Hospital
2014
Ome Municipal General Hospital
2010
Fujitsu (United States)
2005
Microbial Chemistry Research Foundation
1996-2001
Chiba University
1997
Since radioiodination of human granulocyte colony-stimulating factor (G-CSF) is difficult, we synthesized a mutein G-CSF that retains full biological activity and receptor-binding capacity for at least 2 weeks after radioiodination. Receptors were characterized in the plasma membrane fraction from term placenta (human placental membranes) trophoblastic cells by using 125I-labeled (KW-2228). The specific binding KW-2228 to membranes was pH-dependent, with maximal pH 7.8; it increased linearly...
Summary For successful chimeric antigen receptor T (CAR‐T) cell therapy, CAR‐T cells must be manufactured without failure caused by suboptimal expansion. In order to determine risk factors for manufacturing failure, we performed a nationwide cohort study in Japan and analysed patients with diffuse large B‐cell lymphoma (DLBCL) who underwent tisagenlecleucel production. We compared clinical between 30 cases that failed (7.4%) those succeeded ( n = 378). Among the failures, proportion of...
// Ayako Nogami 1 , Gaku Oshikawa Keigo Okada Shusaku Fukutake Yoshihiro Umezawa Toshikage Nagao Tetsuya Kurosu Osamu Miura Department of Hematology, Graduate School Medical and Dental Sciences, Tokyo University, Tokyo, Japan Correspondence to: Miura, e-mail: miura.hema@tmd.ac.jp Keywords: AML, FLT3, PI3K, STAT5, MCL-1 Received: December 02, 2014 Accepted: February 07, 2015 Published: March 16, ABSTRACT FLT3-ITD FLT3-TKD are the most frequent tyrosine kinase mutations in acute myeloid...
FLT3-ITD is the most frequent tyrosine kinase mutation in acute myeloid leukemia (AML) associated with poor prognosis. We previously found that activates mTORC1/S6K/4EBP1 pathway cooperatively through STAT5/PIM and PI3K/AKT pathways to promote proliferation survival by enhancing eIF4F complex formation required for cap-dependent translation. Here, we show that, contrast BCR/ABL causing Ph-positive leukemias, distinctively serine/threonine kinases RSK1/2 activation of MEK/ERK PDK1 transduce...
Several Ephedra Herb-containing Kampo medicines are common initial treatments for various infections; however, the ephedrine alkaloids in Herb can cause side effects by stimulating adrenergic receptors. Accordingly, an alkaloids-free Extract (EFE) has been developed. This study aimed to evaluate whether EFE be used effectively and safely patients with mild coronavirus disease 2019 (COVID-19). We randomized COVID-19 receive equivalent 6 g of per day or a placebo 14 days. The primary efficacy...
FLT3-ITD is the most frequent tyrosine kinase mutation in acute myeloid leukemia (AML) associated with poor prognosis. We previously reported that activation of STAT5 confers resistance to PI3K/Akt inhibitors on FLT3-ITD-positive AML cell line MV4-11 and 32D cells driven by (32D/ITD) but not FLT3 mutated domain (32D/TKD). Here, we report involvement Pim kinases expressed through acquisition this resistance. The specific pan-Pim inhibitor AZD1208 as well PIM447 combination PI3K GDC-0941 or...
Abstract A multicenter, randomized, open-label, phase III study was conducted to compare the efficacy and safety of intravenous ferric derisomaltose (FDI) versus saccharated oxide (SFO) in Japanese patients with iron deficiency anemia associated menorrhagia. FDI can be administered as a single dose up 1000 mg, whereas SFO has maximum 120 mg. The primary endpoint, which change hemoglobin concentration from baseline, noninferior for group compared group. incidence treatment-emergent adverse...
The gain of function mutation JAK2-V617F is very frequently found in myeloproliferative neoplasms (MPNs) and strongly implicated pathogenesis these other hematological malignancies. Here we report establishment a new leukemia cell line, PVTL-1, homozygous for from 73-year-old female patient with acute myeloid (AML) transformed MPN. PVTL-1 positive CD7, CD13, CD33, CD34, CD117, HLA-DR, MPO, has complex karyotypic abnormalities, 44,XX,-5q,-7,-8,add(11)(p11.2),add(11)(q23),−16,+21,−22,+mar1....
The activated JAK2-V617F mutant is very frequently found in myeloproliferative neoplasms (MPNs), and its inhibitor ruxolitinib has been clinical use, albeit with limited efficacies. Here, we examine the signaling mechanisms from responses to JAK2-V617F-positive leukemic cell lines, including PVTL-2, newly established a patient post-MPN secondary acute myeloid leukemia, widely used model line HEL. We have that downregulated mTORC1/S6K/4EBP1 pathway at least partly through inhibition of...
Abstract Methotrexate (MTX)‐associated lymphoproliferative disorder (MTX‐LPD) is a troublesome problem in patients receiving MTX for rheumatoid arthritis (RA). However, its incidence, prognosis, and risk factors remain unclear. In this retrospective study, we evaluated the actual prognostic impact, of MTX‐LPD. Of 986 with RA treated MTX, 90 experienced 95 new malignancies (NMs), LPD as most frequent 26 patients. The cumulative incidences were 1.3% 4.7% at 5 10 years after initiation,...
During the last 3 years, 46 cases of hypertensive intracerebral hemorrhage were treated by CT-guided stereotactic surgery. Our present report is concerned with evaluation this procedure in treatment hematoma, terms rate aspirated hematoma and follow-up study patients. It difficult to draw any definite conclusion about operative indications. aspiration, however, can be evaluated as a less invasive more definitive basal ganglia thalamus.
JAK2-V617F plays a key role in the pathogenesis of myeloproliferative neoplasm. However, its inhibitor ruxolitinib has shown limited clinical efficacies because ruxolitinib-persistent proliferation JAK2-V617F-positive cells. We here demonstrate that USP9X WP1130 or EOAI3402143 (G9) inhibited and induced apoptosis more efficiently cells dependent on than cytokine-activated JAK2. preferentially downregulated activated autophosphorylated by enhancing K63-linked polyubiquitination inducing...
Abstract Background We retrospectively analyzed 80 instances of varicella zoster virus ( VZV ) disease in 72 patients who underwent allogeneic hematopoietic stem cell transplantation HSCT and examined the clinical differences between localized disseminated disease. Risk factors for developing dissemination were also evaluated. Results Of instances, 54 diseases 26 diseases. Patient characteristics did not differ significantly 2 groups, except first‐line therapy duration from symptom onset to...
Innate immune cells play a key role in inflammation as source of pro-inflammatory cytokines. However, it remains unclear how innate immunity-mediated is fine-tuned to minimize tissue damage and assure the host’s survival at early phase systemic inflammation. The results this study with mouse models demonstrate that supply monocytes restricted depending on magnitude During acute severe inflammation, monocytes, but not neutrophils, were substantially reduced by apoptosis remaining...
Reactivation of hepatitis viruses during chemotherapy can be problematic in the treatment malignant lymphomas. However, studies on reactivation chronic C virus (HCV) infection are limited. A 43-year-old woman presented with generalized lymphadenopathy and multiple liver tumors, she was diagnosed follicular lymphoma (grade 3a; clinical stage IV). Chronic HCV clinically diagnosed. Immunochemotherapy (ICT), including bendamustine obinutuzumab, initiated close function monitoring without...
FLT3-ITD and FLT3-TKD are the most frequent tyrosine kinase mutations in acute myeloid leukemia (AML), with former conferring a poor prognosis. We have recently revealed that confers resistance to PI3K/AKT pathway inhibitors by protecting mTORC1/4EBP1/Mcl-1 through Pim kinases induced STAT5 activation AML. The proteasome inhibitor bortezomib has been reported as promising agent for treatment of Here, we show well carfilzomib induces apoptosis intrinsic more conspicuously cells transformed...
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is a protein involved in the regulation of and migration. Interestingly, several PECAM-1-deficient hematopoietic cells exhibit impaired chemotactic responses to stromal cell-derived factor (SDF-1), chemokine essential for B lymphopoiesis bone marrow myelopoiesis. However, whether PECAM-1 SDF-1-regulated chemotaxis unknown. We report here that SDF-1 induces tyrosine phosphorylation at its immunoreceptor tyrosine-based inhibition motifs...
A long-term follow-up study of rostral mesencephalic reticulotomy (RMR) for pain relief is presented. 34 patients (24 males and 10 females) were operated. Ages ranged from 18 to 65 years. The period was 1–70 months. overall effectiveness RMR showed good in 23 (67%). according type 5 out 6 (83%) with nondenervation pain, whereas satisfactory obtained 28 (64%) denervation pain.
Combining whole-body CT scan with a stereotactic system, the authors have developed and applied clinically an apparatus which readily provides intraoperative images, making it possible to confirm location of target point ascertain environment. It takes about 9 s obtain image. Our purpose is make surgery, kind blind as safe reliable visualized procedure by scanning. By method, in there very little invasion under local anesthesia, evacuation deep-seated intracerebral hematomas well brain...