A5103978283- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Food composition and properties
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Cytomegalovirus and herpesvirus research
- Blood disorders and treatments
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Virus-based gene therapy research
- Enzyme Production and Characterization
- Pharmacy and Medical Practices
- Neuroblastoma Research and Treatments
- T-cell and Retrovirus Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Blood transfusion and management
- CNS Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Polysaccharides Composition and Applications
- Transplantation: Methods and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Microbial Metabolites in Food Biotechnology
Okayama University Hospital
2013-2025
Japan Women's University
2012-2025
University of Wisconsin–Madison
2023
JA Toride Medical Center
2023
Okayama University
2002-2022
Okayama Prefecture
2021
Tokyo Medical University
2019
Tokyo Medical University Hospital
2018-2019
The University of Tokyo
2013-2019
Toshiba (Japan)
2018-2019
This paper presents Integrated Information Theory (IIT) 4.0. IIT aims to account for the properties of experience in physical (operational) terms. It identifies essential (axioms), infers necessary and sufficient that its substrate must satisfy (postulates), expresses them mathematical In principle, postulates can be applied any system units a state determine whether it is conscious, what degree, way. offers parsimonious explanation empirical evidence, makes testable predictions concerning...
Summary For successful chimeric antigen receptor T (CAR‐T) cell therapy, CAR‐T cells must be manufactured without failure caused by suboptimal expansion. In order to determine risk factors for manufacturing failure, we performed a nationwide cohort study in Japan and analysed patients with diffuse large B‐cell lymphoma (DLBCL) who underwent tisagenlecleucel production. We compared clinical between 30 cases that failed (7.4%) those succeeded ( n = 378). Among the failures, proportion of...
Mechanisms of prolonged cytopenia (PC) after chimeric antigen receptor (CAR) T-cell therapy, an emerging therapy for relapsed or refractory diffuse large B-cell lymphoma, remain elusive. Haematopoiesis is tightly regulated by the bone marrow (BM) microenvironment, called 'niche'. To investigate whether alterations in BM niche cells are associated with PC, we analysed CD271+ stromal biopsy specimens and cytokine profiles serum obtained before on day 28 CAR infusion. Imaging analyses revealed...
Modifying effects of curcumin (derived from the rhizome Curcuma longa L.) during initiation or post‐initiation phase N ‐nitrosomethylbenzylamine (NMBA)‐induced esophageal carcinogenesis were investigated in male F344 rats. Five‐week‐old rats divided into 5 groups, and groups 1, 2 3 given intraperitoneal injections NMBA (0.5 mg/kg body weight/injection 15 times) for weeks 7 old to induce neoplasms. Groups fed diet containing 500 ppm phases, respectively. Group 4 was throughout experiment,...
The moisture sorption, rheological, and glass transition properties of puffed cereals, such as brown rice, barley, adlay, amaranth, were assessed. cereals stored in desiccators until their content reached equilibrium. Moisture sorption isotherms measured, monomolecular adsorption was calculated through Brunauer-Emmett-Teller (BET) analysis. temperature (Tg) determined, the internal structure observed using a scanning electron microscope. rupture force apparent elastic modulus decreased with...
Abstract Therapies that effectively suppress graft-versus-host disease (GVHD) without compromising graft-versus-leukemia/lymphoma (GVL) effects is important in allogeneic hematopoietic stem cell transplantation (allo-HSCT) for malignancies. Geranylgeranylacetone (GGA) a main component of teprenone, gastric mucosal protectant commonly used clinical practice. In preclinical models, GGA suppresses proinflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α...
The advent of anti-CD19 chimeric antigen receptor-T cell therapy has dramatically changed the treatment strategy for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). Three products are recently available in Japan, but to best our knowledge, real-world data only tisagenlecleucel. This study was a retrospective analysis 27 patients who received axicabtagene ciloleucel (axi-cel) R/R DLBCL at institution. Cytokine release syndrome and immune effector cell-associated neurotoxicity...
No established criteria exist for assessing the effectiveness of granulocyte transfusion (GTX) or biomarkers predicting fatal infections in neutropenia. This study aimed to assess whether a novel sepsis marker, presepsin (P-SEP), is useful prognostic indicator during GTX. We collected frozen serum from 8 patients who had undergone GTX between September 2022 and October 2023 measured their P-SEP levels. compared these results with clinical records assessed alterations before after association...
The purpose of this study was to determine whether the late component somatosensory evoked potentials (SEP) induced by electrical tooth stimulation and pain intensity are inhibited heterotopic ischemic stimulation. tourniquet pressure with 50 mmHg greater than individual's systolic applied left upper arm for 10 min as conditioning SEP visual analogue scale (VAS) were recorded at 4 times both significantly decreased when applied. maximum reductions in amplitude VAS value 26.1% 21.2%,...
Recent developmental studies have shown the importance of interaction with environment resulting from fetal spontaneous movements for formation body maps in spinal cord and primary somatosensory area. However, underlying mechanism as well factors which contribute to development is largely unknown. Here, we simulated map using a human fetus simulation, investigated contribution three often differ normal fetuses preterms: (i) environment, (ii) nervous system (iii) movement patterns. The model...
We experimentally demonstrate a giant voltage-controlled magnetic anisotropy (VCMA) coefficient in crystallographically strained CoFe layer (∼15 monolayers thickness) MgO/CoFe/Ir system. observed strong applied voltage dependence of saturation field and an asymmetric concave behavior with VCMA coefficients −758 1043 fJ V−1 m−1. The result structural analysis reveals epitaxial growth layers the orientation relationship MgO(001)[110] ∥ CoFe(001)[100] Ir(001)[110]. has bcc structure tetragonal...
Abstract The distribution and clinical impact of cell-of-origin (COO) subtypes diffuse large B-cell lymphoma (DLBCL) outside Western countries remain unknown. Recent literature also suggests that there is an additional COO subtype associated with the germinal center dark zone (DZ) warrants wider validation to generalize relevance. Here, we assembled a cohort Japanese patients untreated DLBCL determined refined subtypes, which include DZ signature (DZsig), using NanoString DLBCL90 assay. To...
Cytochrome a-type terminal oxidases derived from Thiobacillus novellus and Nitrobacter agilis have been purified to a homogeneous state as judged their electrophoretic behavior subunit structures studied by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. The T. enzyme is composed two kinds subunits 32,000 23,000 daltons its minimum molecular weight 55,000 on basis heme content amino acid composition. N. also has 40,000 27,000 66,000 Therefore, molecule each...
We examined serum levels of the angiogenic factors, vascular endothelial growth factor (VEGF), basic fibroblast (bFGF), and hepatocyte (HGF), in normal donors for allogeneic peripheral blood stem cell (PBSC) transplantation. Granulocyte colony-stimulating (G-CSF) (filgrastim 400 microg/m2/d) was administered to 23 5 d aphereses were performed on days 4 5. Although bFGF remained at similar after G-CSF treatment, VEGF HGF increased 1.5-fold (n = 13; P 0.02) 6.8-fold 23; < 0.0001) respectively....
This paper presents Integrated Information Theory (IIT) 4.0. IIT aims to account for the properties of experience in physical (operational) terms. It identifies essential (axioms), infers necessary and sufficient that its substrate must satisfy (postulates), expresses them mathematical In principle, postulates can be applied any system units a state determine whether it is conscious, what degree, way. offers parsimonious explanation empirical evidence, makes testable predictions, permits...