A5089002578- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Structural Load-Bearing Analysis
- Chronic Myeloid Leukemia Treatments
- Polyomavirus and related diseases
- Structural Behavior of Reinforced Concrete
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Renal cell carcinoma treatment
- Cytomegalovirus and herpesvirus research
- Structural Engineering and Vibration Analysis
- Neutropenia and Cancer Infections
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Chronic Lymphocytic Leukemia Research
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Testicular diseases and treatments
- Urological Disorders and Treatments
- IgG4-Related and Inflammatory Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Multiple and Secondary Primary Cancers
Kyoto University Hospital
2012-2025
Kyoto University
2016-2025
Nagoya University Hospital
2023
Kurashiki Central Hospital
2008-2019
National Institute of Allergy and Infectious Diseases
2015-2018
National Institutes of Health
2015-2018
Osaka Medical Center for Cancer and Cardiovascular Diseases
1997-2016
Juntendo University
2015
Mitsui (Japan)
2014
Institute of Technology of Cambodia
2014
Fluctuations in heart rate above 0.03 Hz reflect autonomic modulation of sinoatrial node activity. To assess the dynamics nervous activity during and immediately after exercise, we determined power spectrum respiratory fluctuations 43 normal subjects without known cardiac disease, 8 patients with severe congestive failure, 6 status-post transplantation before, during, graded-work load exercise on a cycle ergometer. Before (spectral power) at both high (0.15-0.80 Hz) low (0.03-0.15...
Transplantation-associated thrombotic microangiopathy (TA-TMA) is a devastating complication of hematopoietic stem cell transplantation. TA-TMA likely represents the final stage vascular endothelial injury; however, its pathophysiology largely unknown, making clinical management difficult. Recently, association neutrophil extracellular traps (NETs) with development thrombocytopenic purpura and hemolytic uremic syndrome has been reported. Thus, we explored whether NETs are also relevant to...
Refractoriness to platelet transfusion is a major problem in small group of patients, and large-scale manufacturing clinical grade functional platelets ex vivo has remained an elusive goal. Sugimoto et al report on the results first trial autologous induced pluripotent stem cell (iPSC)-derived patient who had severe aplastic anemia but no compatible donor. Using methodology described complementary article Blood Advances, provide proof-of-principle illustrate challenges be faced taking this...
Summary For successful chimeric antigen receptor T (CAR‐T) cell therapy, CAR‐T cells must be manufactured without failure caused by suboptimal expansion. In order to determine risk factors for manufacturing failure, we performed a nationwide cohort study in Japan and analysed patients with diffuse large B‐cell lymphoma (DLBCL) who underwent tisagenlecleucel production. We compared clinical between 30 cases that failed (7.4%) those succeeded ( n = 378). Among the failures, proportion of...
Prolonged hematotoxicity is the most common long-term adverse event in chimeric antigen receptor (CAR) T-cell therapy. In order to evaluate impact on prolonged cytopenia of inflammatory status after CAR-T cell infusion, we performed a single-center retrospective study and analyzed patients with B-cell lymphomas infusion. Among 90 days cumulative incidence was 57.5% for neutropenia, 36.7% anemia, 49.8% thrombocytopenia. Patients who experienced cytokine-release syndrome (CRS) had...
Craniocervical edema appears soon after chimeric antigen receptor T-cell (CAR-T) therapy in some cases. This phenomenon is often observed right systemic cytokine release syndrome (CRS), and it called local CRS (L-CRS). In severe cases, L-CRS causes airway obstruction asphyxia, but not yet well known among hematologists. this report, we present mild cases of L-CRS. Tocilizumab might have limited efficacy against L-CRS, early administration corticosteroids can be important. We hope that case...
The abnormal immune response accompanying IgG4-related autoimmune pancreatitis (AIP) is presently unclear. In this study, we examined the role of plasmacytoid dendritic cell (pDC) activation and IFN-α production in disease as well a murine model AIP (MRL/Mp mice treated with polyinosinic-polycytidylic acid). We found that development MRL/Mp occurred parallel pancreatic accumulation pDCs producing IFN-α, pDC depletion IFN-α-blocking studies, showed such was necessary for induction. addition,...
Abstract In previous studies, we found that human IgG4-related autoimmune pancreatitis (AIP) and murine AIP are driven by activation of plasmacytoid dendritic cells (pDCs) producing IFN-α. the present studies examined additional roles pDC-related mechanisms in pathogenesis, particularly those responsible for induction fibrosis. We (MRL/Mp mice treated with polyinosinic-polycytidylic acid) not only pancreatic infiltration immune but also development fibrosis were markedly reduced depletion...
The transcription factor nuclear factor-kappaB (NF-kappaB) has been shown to be constitutively activated in various human malignancies, including leukemia, lymphoma and a number of solid tumors. NF-kappaB regulates the transcriptional genes important for tumor invasion, metastasis chemoresistance. sesquiterpene lactone parthenolide, an inhibition NF-kappaB, used conventionally treat migraines inflammation. In this study, renal cancer cell lines OUR-10 ACHN were vitro experiments evaluate...
Key Points The machine learning algorithms produced clinically reasonable and robust risk stratification scores for aGVHD. Predicting aGVHD also demonstrated the link between of development overall survival after HSCT.
We report a novel approach to bone marrow (BM) conditioning using c-kit-targeted chimeric antigen receptor T (c-kit CAR-T) cells in mice. Previous reports anti-c-kit or anti-CD45 antibody linked toxin such as saporin have been promising. developed distinctly different c-kit CAR-T cells. Initial studies demonstrated vitro killing of hematopoietic stem by but poor expansion vivo and migration into BM. Pre-treatment recipient mice with low-dose cyclophosphamide (125 mg/kg) together CXCR4...
Abstract Unrelated cord blood transplantation (CBT) is an alternative curative option for adult patients with acute myeloid leukemia (AML) who need allogeneic hematopoietic cell (HCT) but lack HLA-matched related or unrelated donor. However, large-scale data are lacking on CBT outcomes unselected AML. To investigate the trends of survival and engraftment after over past 22 years, we retrospectively evaluated AML in Japan according to time period (1998–2007 vs 2008–2013 2014–2019). A total...
Abstract Background The use of Bio 3D nerve conduits is a promising approach for peripheral reconstruction. This study aimed to assess their safety in three patients with defects hands. Methods We describe single institution, non-blinded, non-randomised control trial conducted at Kyoto University Hospital. Eligibility criteria included severed injuries or defect the region distal wrist joint not caused by congenital anomaly; length ≤20 mm diameter ≤2 mm; failed results sensory functional...
Abstract Introduction Understanding differences in clinical outcomes between PBSCT and BMT is important, this study compared of HLA‐matched related using reduced‐intensity conditioning (RIC) adult acute myeloid leukemia (AML) patients. Methods Data from 402 patients who underwent either ( n = 294) or 108) 2000 2022 were analyzed the Japanese nationwide registry database. The primary endpoint was overall survival (OS), secondary endpoints included disease‐free (DFS), non‐relapse mortality...
Abstract Umbilical cord blood transplantation (CBT) is accepted as an effective treatment for acute myeloid leukemia (AML), and reduced-intensity conditioning (RIC), rather than myeloablative (MAC) regimens allowed elderly patients to be treated safely. However, appropriate intensities of are still unclear, especially middle-aged patients. To compare outcomes after RIC MAC regimens, we analyzed AML aged 16 years or older in the Japanese registry database, who underwent single unit CBT...
Abstract Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, so far, no large cohort study determined the risk factors and most effective therapeutic strategies for TA-TMA. Thus, present aimed to clarify these clinical aspects based on multicenter cohort. This retrospective was performed by Kyoto Stem Cell Transplantation Group (KSCTG). A total 2425 patients were enrolled from 14...