A5088763525- Nerve injury and regeneration
- Orthopedic Surgery and Rehabilitation
- Nerve Injury and Rehabilitation
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Elbow and Forearm Trauma Treatment
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Organ and Tissue Transplantation Research
- Reconstructive Surgery and Microvascular Techniques
- Hip disorders and treatments
- Hematopoietic Stem Cell Transplantation
- Peripheral Nerve Disorders
- Bone and Joint Diseases
- Electrospun Nanofibers in Biomedical Applications
- Bone fractures and treatments
- Shoulder Injury and Treatment
- Nutrition and Health in Aging
- Stroke Rehabilitation and Recovery
- Wound Healing and Treatments
- Cancer survivorship and care
- Lower Extremity Biomechanics and Pathologies
- Knee injuries and reconstruction techniques
- Tea Polyphenols and Effects
- Transplantation: Methods and Outcomes
Kyoto University Hospital
2016-2025
Kyoto University
2015-2024
Saga University
2021
Kyoto University of Education
2021
GTx (United States)
2020
Foundation for Physical Medicine and Rehabilitation
2020
Yawata Medical Center
2016
Kobe City Medical Center General Hospital
2011-2014
Kobe Central Hospital
2011
Mayo Clinic Health System
2011
Although autologous nerve grafting is the gold standard treatment of peripheral injuries, several alternative methods have been developed, including conduits that use supportive cells. However, seeding efficacy and viability cells injected in grafts remain unclear. Here, we focused on a novel completely biological, tissue-engineered, scaffold-free conduit.We developed six from human normal dermal fibroblasts using Bio 3D Printer. Twelve adult male rats with immune deficiency underwent...
Idiopathic osteonecrosis of femoral head (ION) is a painful disorder that progresses to collapse the and destruction hip joint. Although its precise pathology remains unknown, loss blood supply causing living bone-forming cells hallmark pathophysiology osteonecrosis. Transplantation multipotent mesenchymal stromal (MSCs) promising tool for regenerating musculoskeletal system. The aim present study was assess safety efficacy transplantation cultured autologous bone marrow-derived MSCs mixed...
Abstract Background The use of Bio 3D nerve conduits is a promising approach for peripheral reconstruction. This study aimed to assess their safety in three patients with defects hands. Methods We describe single institution, non-blinded, non-randomised control trial conducted at Kyoto University Hospital. Eligibility criteria included severed injuries or defect the region distal wrist joint not caused by congenital anomaly; length ≤20 mm diameter ≤2 mm; failed results sensory functional...
OBJECTIVE Selective intraindividual weakness in successive processing, which is a unique verbal working memory scale included the Das-Naglieri Cognitive Assessment System (CAS), considered one of intrinsic neurocognitive characteristics pediatric moyamoya disease (MMD). The aim study was to elucidate association between cerebral blood flow (CBF) and identify regions related weakness. METHODS present cross-sectional children who had been diagnosed with MMD were assessed using...
Autologous nerve grafting is widely accepted as the gold standard treatment for segmental defects. To overcome inevitable disadvantages of original method, alternative methods such tubulization technique have been developed. Several studies investigated characteristics an ideal conduit in terms supportive cells, scaffolds, growth factors, and vascularity. Previously, we confirmed that biological scaffold-free conduits fabricated from human dermal fibroblasts promote regeneration a rat...
Cells, scaffolds, growth factors, and vascularity are essential for nerve regeneration. Previously, we reported that the insertion of a vascular bundle implantation bone marrow-derived mesenchymal stem cells (BM-MSCs) into conduit promoted peripheral In this study, efficacy conduits containing bundle, BM-MSCs, thermally decellularized allogenic matrix (DANM) was investigated using rat sciatic model with 20-mm defect. Lewis rats were used as preparation Dark Agouti DANM. The revascularization...
Abstract This study investigated the link between pre-stroke and acute-stage physical activity (PA) sedentary behavior. Forty individuals with stroke (aged 73.6 ± 8.9 years) were enrolled. Post-stroke activity, including metabolic equivalents (METs), behavior, light PA, moderate-to-vigorous PA (MVPA), was measured using a tri-axial accelerometer (ActiGraph wGT3X-BT) over 11 consecutive days starting from 4th day post-stroke. Pre-stroke levels assessed International Physical Activity...
Purpose: To elucidate the relation between certain preoperative physical parameters and walking with a limp after total hip arthroplasty (THA) determine whether it is possible to predict ability of patients 6 months THA. Methods: The subjects this study comprised 74 female who had undergone unilateral Before surgery, abductor knee extensor strengths were measured, cross-sectional areas (CSAs) gluteus medius rectus abdominis muscles Timed Up Go test was conducted. then divided into two groups...
Abstract Although autologous nerve grafting is widely accepted as the gold standard treatment for segmental defects, harvesting nerves highly invasive and leads to functional loss of ablated part. In response, artificial conduits made materials have been reported, but efficacy regeneration still needs improvement. The purpose this study investigate mechanism Bio three-dimensional (3D) conduit composed xeno-free human induced pluripotent stem cell–derived mesenchymal cells (iMSCs). 5-mm gap...
Background. We showed recently that limb allograft survival could be enhanced by administration of alloantigen (Ag)-pulsed immature dendritic cells (DC) after transplantation. Since indefinite graft was not achieved, we have further modified the DC pharmacologic (rapamycin; Rapa) conditioning and ascertained their influence on survival, without continued immunosuppressive therapy. Methods. compared ability donor Ag-pulsed, Rapa-conditioned rat myeloid (Rapa DC) control (CTR to inhibit...
Purpose: The purpose of this study was to investigate the effects an exercise program focusing on hip external rotator muscle physical recovery in early post-operative period total arthroplasty (THA).Methods: Patients who underwent THA were randomized group (n = 14) or a control 14). In group, performed 5 times per week for four weeks. Outcome measures pain, range motion, strength lower extremity and Timed Up Go (TUG) test.Results: Both abductor (effect size 0.60) TUG test size= −0.53)...
There have been several reports that partial ulnar transfer (PUNT) is preferable for reconstructing elbow flexion in patients with upper brachial plexus injuries (BPIs) compared intercostal nerve (ICNT). The purpose of this study was to compare the recovery between subjected PUNT and ICNT.
Abstract Introduction A Bio 3D printed nerve conduit was reported to promote regeneration in a 5 mm gap model. The purpose of this study fabricate conduits suitable for 10 and evaluate their capacity rat sciatic defect Materials Methods Eighteen F344 rats with immune deficiency (9–10 weeks old; weight, 200–250 g) were divided into three groups: group (Bio 3D, n = 6), graft (NG, silicon tube (ST, 6). 12‐mm or transplanted the 10‐mm right nerve. In group, reverse autografting performed an...
Previously, we developed a Bio3D conduit fabricated from human fibroblasts and reported significantly better outcome compared with artificial nerve in the treatment of rat sciatic defect. The purpose this study is to investigate long-term safety regeneration treatments using autologous transplantation.We used 15 immunodeficient rats randomly divided them into three groups treated (
Bone marrow-derived cells (BMCs) are multipotent that have the potential to differentiate into bone, cartilage, fat, muscle, or neuronal lineages such as neurons and glial cells. A silicone tube model containing reverse-pedicled sural vessels was created in sciatic nerves of Lewis rats. About 1 × 107 BMCs, removed from bone marrow synergetic rat femurs cultured vitro, were transplanted 15-mm-long chambers tubes. Nerve regeneration vessel-containing tubes had received BMCs significantly...
Previously, we showed that undifferentiated bone marrow stromal cell (uBMSC) implantation and vessel insertion into a nerve conduit facilitated peripheral regeneration in rodent model. In this study, investigated the efficacy of uBMSC-laden vessel-containing repair segmental defects, using canine Eight beagle dogs were used study. Thirty-millimeter ulnar defects repaired with conduits (right forelimbs, n = 8) or autografts (left 7). group, artery was inserted l-lactide/ε-caprolactone tube,...
Abstract Background The reduction of systemic immunosuppressive agents is essential for the expansion vascularized composite allotransplantation (VCA) in a clinical setting. purpose this study to compare human‐induced pluripotent stem cell‐derived mesenchymal cells (iMSCs) with four other types (human bone marrow‐derived MSCs [BMMSCs], human adipose‐derived [ADMSCs], rat BMMSCs, and ADMSCs) vitro, investigate vivo immunomodulatory effect iMSCs VCA model. Materials methods One Brown Norway...