A5100343137- Glioma Diagnosis and Treatment
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Virology and Viral Diseases
- Ferroptosis and cancer prognosis
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Retinal Imaging and Analysis
- Cytomegalovirus and herpesvirus research
- Retinal and Optic Conditions
- Radiomics and Machine Learning in Medical Imaging
- interferon and immune responses
- Ocular Diseases and Behçet’s Syndrome
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Respiratory viral infections research
- MicroRNA in disease regulation
- Vascular Malformations Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Traumatic Ocular and Foreign Body Injuries
- HIV Research and Treatment
- Streptococcal Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
Qingdao Agricultural University
2024-2025
Beijing Tian Tan Hospital
2015-2025
Capital Medical University
2015-2025
China Animal Health and Epidemiology Center
2009-2025
Fudan University
2008-2024
Huashan Hospital
2017-2024
Weifang Medical University
2024
People's Hospital of Cangzhou
2024
Shanghai Ninth People's Hospital
2009-2023
Weifang People's Hospital
2023
The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations diagnostic and therapeutic procedures. covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation medical oncologists clinical trial experts. task made clearer more transparent choices about outcomes considered most relevant through searching the references evaluating their value. scientific evidence papers...
Abstract Preoperative MRI is one of the most important clinical results for diagnosis and treatment glioma patients. The objective this study was to construct a stable validatable preoperative T2-weighted MRI-based radiomics model predicting survival gliomas. A total 652 patients across three independent cohorts were covered in including their images, RNA-seq data. Radiomic features (1731) extracted from images 167 gliomas (discovery cohort) collected Beijing Tiantan Hospital then used...
Abstract Serologic and molecular evidence indicates that peste des petits ruminants virus (PPRV) infection has emerged in goats sheep the Ngari region of southwestern Tibet, People's Republic China. Phylogenetic analysis confirms PPRV strain from Tibet is classified as lineage 4 closely related to viruses currently circulating neighboring countries southern Asia.
A novel semi-interpenetrating polymer network (semi-IPN) membrane composed of crosslinked chitosan(cr-CS) and poly(acrylic acid) (PAA) was prepared. Evidence from infrared spectra proved the formation polyelectrolyte complex through electrostatic interaction between groups CS COO− PAA. The semi-IPN swelled at high pH low exhibited a typical pH-sensitivity. Its swelling degrees in different salt solutions with same ionic valence equal strength were on similar levels. Under certain (I = 1.5...
Gliomas are the most common malignant tumors of brain. Immune checkpoints have been increasingly emphasized as targets for treating tumors. B7‐H3 has identified an immune checkpoint that shows potential value targeting therapies. We set out to characterize expression pattern and biological function in brain gliomas using high‐throughput data obtained from Chinese Glioma Genome Atlas (CGGA) Cancer (TCGA) projects. was upregulated more higher‐grade than lower‐grade both CGGA TCGA datasets....
Brain glucose hypometabolism is an invariant feature and has significant diagnostic value for Alzheimer's disease. Thiamine diphosphate (TDP) a critical coenzyme metabolism significantly reduced in brain blood samples of patients with disease (AD).To explore the measurement thiamine metabolites AD.Blood TDP, monophosphate, levels were detected using high performance liquid chromatography (HPLC). The study included exploration validation phases. In phase, 338 control subjects 43 AD utilized...
// Jinquan Cai 1, 7, * , Ping Zhu 4, Chuanbao Zhang 2, 3, Qingbin Li 7 Zhiliang Wang Guanzhang Guangzhi Pei Yang Jianlong Bo Han Chuanlu Jiang Ying Sun Tao 5, 6, 1 Department of Neurosurgery, The Second Affiliated Hospital Harbin Medical University, Harbin, China 2 Beijing Neurosurgical Institute, Capital Beijing, 3 Tiantan Hospital, 4 Otolaryngology, Union Tongji College, Huazhong University Science and Technology, Wuhan, 5 Institute for Brain Disorders Tumor Center, 6 National Clinical...
Recent evidence has confirmed that a mutation of the isocitrate dehydrogenase (IDH) gene occurs early in gliomagenesis and contributes to suppressed immunity. The present study aimed determine candidate genes associated with IDH status could serve as biomarkers immune suppression for improved prognosis prediction. Clinical information RNA-seq expression data were collected 932 glioma samples from CGGA TCGA databases, differentially expressed both lower-grade (LGG) glioblastoma (GBM)...
Transcriptomic data derived from bulk sequencing have been applied to delineate the tumor microenvironment (TME) and define immune subtypes in various cancers, which may facilitate design of immunotherapy treatment strategies. We herein gathered published gene expression diffuse lower-grade glioma (LGG) patients identify subtypes. Based on profiles 402 LGG The Cancer Genome Atlas, we performed consensus clustering determine robust clusters patients, evaluated their reproducibility three...
African swine fever is a highly transmissible and lethal infectious disease caused by the virus (ASFV), which has considerably impacted global industry. Lipid metabolism plays vital role in sustaining lipid energy homeostasis within cells influences viral life cycle. In this study, we found that ASFV infection disrupts host. Transcriptomic analysis of infected with revealed levels significantly changed as duration progressed. The intracellular cholesterol host exhibited pattern similar to...
Purpose Atypical teratoid/rhabdoid tumors (ATRTs) are very rare, highly malignant embryonal neoplasms in central nervous system. The aim of this study was to conduct a retrospective analysis ATRT patient survival and investigate the prognostic factors associated with ATRT. Methods A conducted using information patients who received treatment between 2016 2021 Beijing Tiantan Hospital. Kaplan–Meier curves were used for overall (OS) analysis. Univariate multivariate COX analyses applied OS...
Recurrence and progression to higher grade lesions are key biological events characteristic behaviors in the evolution process of glioma.Malignant astrocytic tumors such as glioblastoma (GBM) most lethal intracranial tumors.However, clinical practicability significance molecular parameters for diagnostic prognostic prediction is still limited.In this study, we detected ATRX, IDH1-R132H Ki-67 by immunohistochemistry observed association with ATRX expression.There was a strong between loss...
Objective . To examine the changes in retinal thickness of patients with diabetes without DR. Designs A randomization, crossover, retrospective practice. Participants 43 diabetic and ethnic-, age-, sex-matched controls. Methods Full thicknesses ten areas were assessed using spectral domain optical coherence tomography. Confounding variables, such as age, gender, glycated haemoglobin (HbA1c) level, by regression analysis. Main Outcome Measures Mean areas. Results The mean fovea was 215.8 ±...
Background: Gliomas are aggressive tumors with various molecular and clinical characteristics exhibit strongly resistance to radio-chemotherapy. Programmed cell death 1 ligand 2 (PD-L2) is a surface protein, which was reported in many cancers, modulating cancer-associated immune responses, while the role of PD-L2 gliomas remained unclear. Herein, we aimed investigate biological behaviors prognostic values gliomas.Methods: Totally, enrolled RNA sequencing data 325 glioma samples from Chinese...
Abstract Isocitrate dehydrogenase (IDH) mutant glioblastoma (GBM), accounts for ~10% GBMs, arises from lower grade diffuse glioma and preferentially appears in younger patients. Here, we aim to establish a robust gene expression-based molecular classification of IDH-mutant GBM. A total 33 samples the Chinese Glioma Genome Atlas RNA-sequencing data were selected as training set, 21 cases microarray used validation set. Consensus clustering identified three groups with distinguished prognostic...
// Chuan-Bao Zhang 1, 2, 3, 4, * , Ping Zhu 5, Pei Yang 4 Jin-Quan Cai 6 Zhi-Liang Wang Qing-Bin Li Zhao-Shi Bao Wei Tao Jiang 1 Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China 2 Neurosurgery, Tiantan Hospital, 3 Center Brain Tumor, Institute for Disorders, National Clinical Research Neurological Diseases, 5 Otolaryngology, Union Tongji College, Huazhong University Science and Technology, Wuhan, The Second Affiliated...