A5101591733- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Meningioma and schwannoma management
- Neurobiology of Language and Bilingualism
- Epilepsy research and treatment
- Ferroptosis and cancer prognosis
- Pharmacological Effects and Toxicity Studies
- Transcranial Magnetic Stimulation Studies
- Peripheral Nerve Disorders
- MicroRNA in disease regulation
- Cancer-related cognitive impairment studies
- Cancer Genomics and Diagnostics
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Intraoperative Neuromonitoring and Anesthetic Effects
- EEG and Brain-Computer Interfaces
- Neurosurgical Procedures and Complications
- Fluoride Effects and Removal
- Extracellular vesicles in disease
- Brain Tumor Detection and Classification
- Stroke Rehabilitation and Recovery
Capital Medical University
2016-2025
Beijing Tian Tan Hospital
2019-2025
Beijing Institute of Neurosurgery
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Capital University
2020
Beijing Administration Institute
2020
Chinese Institute for Brain Research
2019
Brown University
2019
Rhode Island Hospital
2019
Zhejiang Center for Disease Control and Prevention
2008
Abstract The prognosis for diffusely infiltrating gliomas at World Health Organization (WHO) grade 2–4 remains dismal due to their heterogeneity. rapid development of genome-wide molecular-profiling-associated studies has greatly promoted the accuracy glioma classification. Thus, latest version WHO classification central nervous system tumors published in 2021 incorporated more molecular biomarkers together with histological features diagnosis gliomas. Advanced usage pathology clinical...
Objective Accumulating evidence from invasive cortical stimulation mapping and noninvasive neuroimaging studies indicates that brain function may be preserved within tumors. However, a approach to accurately comprehensively delineate individual‐specific functional networks in the whole brain, especially tissues surrounding tumors, is still lacking. The purpose of study develop clinically useful technique can map regions tumoral brains. Methods We developed an network parcellation using...
Abstract Background This study proposed a classification system for the interaction between gliomas and white matter tracts, exploring its potential associations with clinical characteristics, tumor pathological subtypes, patient outcomes. Methods Clinical data diffusion MRI from 360 glioma patients who underwent craniotomy were analyzed. Using automatic fiber tractography, glioma-tract relationships categorized into three types: displacement, infiltration, disruption. Double...
The aim of this study was to investigate the epidemiological characteristics, associated risk factors, and prognostic value glioma-related epilepsy in patients with diffuse high-grade gliomas (DHGGs) that were diagnosed after 2016 updated WHO classification released.Data from 449 DHGGs retrospectively collected. Definitive diagnosis reaffirmed according classification. Seizure outcome assessed using Engel at 12 months surgery. Univariate multivariate analyses performed identify factors...
Brick tea-drinking fluorosis is an unusual environmental problem. As a result of investigation habits, total fluoride intakes, dental fluorosis, and skeletal this disease has been found in the Sichuan Province China Tibetans with long history drinking brick tea. The 375 Tibetan children (213 males, 162 females) 161 Han (86 75 females), 8-15 years age, was carried out Daofu County, Province. According to standard Chinese Health Ministry, survey 658 (264 394 41 Hans (20 11 all over 16 old,...
<h3>BACKGROUND AND PURPOSE:</h3> The accuracy of preoperative blood oxygen level–dependent fMRI remains controversial. This study assessed the association between anatomic location a tumor and fMRI-based motor function mapping in diffuse lower-grade gliomas. <h3>MATERIALS METHODS:</h3> Thirty-five patients with gliomas involving areas underwent scans grasping tasks received intraoperative direct cortical stimulation. Patients were classified into an overlapping group nonoverlapping group,...
Abstract Susceptibility-weighted imaging (SWI) can be a useful tool to depict vascular structures in brain tumors as well micro-bleedings, which represent tumor invasion blood vessels and could also representative of tumoral angiogenesis. In this study, we investigated the relationship between SWI features glioma grades, expression key molecular markers isocitrate dehydrogenase 1 ( IDH1 ), O-6-methylguanine-DNA methyltransferase MGMT 1p19q. The gliomas were graded according intratumoral...
The A disintegrin and metalloproteinase 9 (ADAM9) protein has been suggested to promote carcinoma invasion appears be overexpressed in various human cancers. However, its role rarely investigated gliomas and, thus, the current study we have evaluated ADAM9 expression examined relevance of prognosis glioma patients. Clinical characteristics, RNA sequence data, case follow-ups were reviewed for 303 patients who had histological, confirmed gliomas. between lower-grade (LGG) glioblastoma (GBM)...
Abstract Aims We aimed to clarify the relationship between alterations in functional networks and glioma‐related epilepsy (GRE) patients with different molecular diagnoses. Methods enrolled 160 prefrontal gliomas histories of GRE. The were grouped based on latest pathological glioma classification GRE history. Graph theory analysis was applied reveal sensorimotor among various subgroups. Binary logistic regression used identify risk factors for preoperative onset. Results Decreasing shortest...
The detection of mutations in telomerase reverse transcriptase promoter (p TERT ) is important since preoperative diagnosis p status helps with evaluating prognosis and determining the surgical strategy. Here, we aimed to establish a radiomics-based machine-learning algorithm evaluated its performance regard prediction patients World Health Organization (WHO) grade II gliomas. In total, 164 WHO gliomas were enrolled this retrospective study. We extracted total 1,293 radiomics features from...
Background: Seizures are a common symptom in patients with temporal lobe gliomas and may result brain network alterations, but changes caused by glioma-related epilepsy remain poorly understood. In this study, we applied graph theory analysis to delineate topological networks resting-state functional magnetic resonance images investigated the characteristics of epilepsy. Methods: Thirty low grade left were enrolled classified into epileptic (n =15) non-epileptic groups. Twenty healthy...
The present study aimed to preoperatively predict the status of 1p/19q based on radiomics analysis in patients with World Health Organization (WHO) grade II gliomas.This retrospective enrolled 157 WHO gliomas (76 astrocytomas mutant IDH, 16 wild-type and 65 oligodendrogliomas IDH codeletion). Radiomic features were extracted from magnetic resonance images, including T1-weighted, T2-weighted, contrast T1-weighted images. Elastic net support vector machines radial basis function kernel applied...
This study aims to investigate the structural reorganization in sensorimotor area of brain patients with gliomas, distinguishing between those impaired and unimpaired strength. Using voxel-based morphometry (VBM) region interest (ROI) analysis, gray matter volumes (GMV) were compared contralesional primary motor gyrus, sensory premotor area, bilateral supplementary medial Brodmann 8 (BA8). The results revealed that right hemisphere BA8 volume was significantly larger group than group, both...
Use of conventional blood oxygen level-dependent functional magnetic resonance imaging (conventional-BOLD-fMRI) presents challenges in accurately identifying the hand-motor cortex when a glioma involves ipsilateral hand-knob. Zoomed technique with parallel transmission (ZOOMit)-BOLD is novel sequence allowing high spatial resolution relatively small field view that may solve this problem.To compare accuracy ZOOMit-BOLD and conventional-BOLD identification.A total 20 patients gliomas...
Glioma-related epilepsy (GRE) is a common symptom in patients with prefrontal glioma. Epilepsy onset associated functional network alterations. This study investigated alterations of networks glioma and GRE.Sixty-five lobe gliomas were retrospectively assessed classified into GRE non-GRE groups. Additionally, 25 healthy participants enrolled after matching for general information. Imaging data acquired within 72 h pre-operation. The sensorimotor was used to delineate connectivity (FC)...
Diffuse low-grade gliomas (DLGGs) growing on the insular lobe induce contralesional hemispheric compensation of damaged functioning by increasing cortical volumes. However, it remains unclear how functional networks are altered in patients with DLGGs during compensation. Thirty-five were classified into left (insL, n = 16) and right groups (insR, 19), 33 healthy subjects included control group. Resting state magnetic resonance imaging was used to generate connectivity (FC), network...
Abstract Aims We analyzed the resting state functional magnetic resonance images to investigate alterations of neural networks in patients with glioma‐related epilepsy (GRE). Methods Fifty‐six right temporal lower‐grade glioma were divided into GRE ( n = 28) and non‐GRE groups. Twenty‐eight healthy subjects recruited after matching age, sex, education level. Sensorimotor, visual, language, left executive control applied generate connectivity matrices, their topological properties...