A5025820201- Aortic aneurysm repair treatments
- Gastrointestinal motility and disorders
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Migraine and Headache Studies
- Renal and Vascular Pathologies
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Heart Rate Variability and Autonomic Control
- Psychosomatic Disorders and Their Treatments
- Circadian rhythm and melatonin
- Advanced Neuroimaging Techniques and Applications
- Music Therapy and Health
- EEG and Brain-Computer Interfaces
- Neurobiology and Insect Physiology Research
- Trigeminal Neuralgia and Treatments
- Pain Management and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Advanced MRI Techniques and Applications
- Spaceflight effects on biology
- Adipose Tissue and Metabolism
- Vagus Nerve Stimulation Research
- Dermatology and Skin Diseases
The Ohio State University
2024
Corewell Health
2024
Medical University of South Carolina
2020-2023
Harvard University
2016-2020
Massachusetts General Hospital
2018-2020
Athinoula A. Martinos Center for Biomedical Imaging
2019
Boston Children's Hospital
2015-2018
Boston Children's Museum
2018
University of Maryland, Baltimore
2014-2016
Center for Pain and the Brain
2015-2016
<h3>Abstract</h3> To investigate the neuroanatomical and functional brain changes in migraine patients relative to healthy controls, we used a combined analytical approach including voxel- surface-based morphometry along with resting-state connectivity determine whether areas showing structural alterations also showed abnormal connectivity. Additionally, wanted assess these were associated group differences pain catastrophizing migraine-related disease variables patients. We acquired...
A confluence of evidence indicates that brain functional connectivity is not static but rather dynamic. Capturing transient network interactions in the individual requires a technology offers sufficient within-subject reliability. Here, we introduce an individualized network-based dynamic analysis technique and demonstrate it reliable detecting subject-specific states during both resting state cognitively challenging language task. We evaluate extent to which show hemispheric asymmetries how...
Alterations in corticotropin-releasing factor (CRF) signaling pathways have been implicated irritable bowel syndrome (IBS) pathophysiology. We aimed to (1) determine the effect of selective CRF receptor 1 antagonist (CRF ) GW876008 relative placebo, on regional activation and effective connectivity a stress-related emotional–arousal circuit during expectation abdominal pain using functional magnetic resonance imaging human subjects with diagnosis IBS healthy controls (HCs), (2) examine...
Objective Current understanding of the neuromodulatory effects deep brain stimulation (DBS) on large‐scale networks remains elusive, largely due to lack techniques that can reveal DBS‐induced activity at whole‐brain level. Using a novel 3T magnetic resonance imaging (MRI)‐compatible stimulator, we investigated subthalamic nucleus (STN) in patients with Parkinson disease. Methods Fourteen received STN‐DBS treatment and participated block‐design functional MRI (fMRI) experiment, wherein...
Little is known about the effect of migraine on neural cognitive networks. However, dysfunction increasingly being recognized as a comorbidity chronic pain. Pain appears to affect ability and function networks over time, decrements in can exacerbate affective sensory components We investigated differences processing pain–cognition interactions between 14 patients matched healthy controls using an fMRI block-design with two levels task difficulty concurrent heat (painful not painful) stimuli....
Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder of unknown etiology. Although relatively common in children, how this condition affects brain structure and function pediatric population remains unclear. Here, we investigate changes adolescents with IBS healthy controls. Imaging was performed Siemens 3 Tesla Trio Tim MRI scanner equipped 32-channel head coil. A high-resolution T1-weighted anatomical scan acquired followed by T2-weighted scan. We used...
The aim of this study was to identify structural and functional brain changes that accompanied the transition from chronic (CM; ≥ 15 headache days/month) episodic (EM; < migraine following prophylactic treatment with onabotulinumtoxinA. Specifically, we examined whether CM patients responsive prophylaxis (responders; n = 11), as evidenced by a reversal in disease status (defined at least 50% reduction frequency days/month), compared whose remained unchanged (non-responders; 12), showed...
Migraine is a pain disorder associated with abnormal brain structure and function, yet the effect of migraine on acute processing remains unclear. It also unclear whether altered pain-related responses related structural changes are clinical characteristics. Using fMRI three levels thermal stimuli (non-painful, mildly painful, moderately painful), we compared whole-brain activity between 14 patients matched controls. Although, there were no significant differences in thresholds nor pre-scan...
Objective Accumulating evidence from invasive cortical stimulation mapping and noninvasive neuroimaging studies indicates that brain function may be preserved within tumors. However, a approach to accurately comprehensively delineate individual‐specific functional networks in the whole brain, especially tissues surrounding tumors, is still lacking. The purpose of study develop clinically useful technique can map regions tumoral brains. Methods We developed an network parcellation using...
The present study examined whether a moderately aversive abdominal threat would lead to greater enhancement in affect- and pain-related defensive responding as indexed by the acoustic startle reflex (ASR) nociceptive flexion (NFR) women compared men. We also predicted sex differences threat-related autonomic arousal measured skin conductance responses (SCRs) noxious sural nerve stimulation. Unpredictable was manipulated alternating 30-second safe (“no stimulation will be given”) (“abdominal...
Abstract Background Increased attention to gastrointestinal ( GI ) symptoms and disease‐specific contexts may play an important role in the enhanced perception of visceral stimuli frequently reported patients with irritable bowel syndrome IBS ). In this study, we test hypothesis that altered attentional mechanisms underlie central pain amplification . Methods To evaluate brain networks support alerting, orienting, executive attention, employed network ANT ), a modified flanker task which...
A large body of evidence suggests that brain signal complexity (BSC) may be an important indicator healthy functioning or alternately, a harbinger disease and dysfunction. However, despite recent progress our current understanding how BSC emerges evolves in large-scale networks, the factors shape these dynamics, remains limited. Here, we utilized resting-state functional near-infrared spectroscopy (rs-fNIRS) to capture characterize nature time course dynamics within networks 107 participants...
OBJECTIVES: To assess the accuracy of screening for abdominal aortic aneurysms (AAAs) by ultrasound (US). SETTING: An aneurysm programme in Huntingdon. METHODS: False negative tests were identified tracing all patients with a ruptured who screened and then finding number classified as normal on US. positive calculating aneurysmal aortas US that CT. Measurement variability infrarenal diameter between CT was estimated. RESULTS: 14 out 93 AAA since 1991 had been screened. No All 64 an larger...
We used functional MRI and a longitudinal design to investigate the brain mechanisms in previously reported estrogen-dependent visceral hypersensitivity model. hypothesized that noxious stimulation would be associated with activation of insula, anterior cingulate cortex, amygdala, estrogen-dependent, stress-induced both enhance these regions recruit other areas mediating affect reward processing. Ovariectomized rats were treated estrogen (17 β-estradiol, E2) or vehicle ( n = 5 per group)...
While much brain research on fibromyalgia (FM) focuses the study of hyperresponsiveness to painful stimuli, some studies suggest that increased pain-related activity often reported in FM may be partially explained by stronger responses salient aspects stimulation rather than, or addition to, stimulation's painfulness. Therefore, this was undertaken test our hypothesis patients would demonstrate elevated both pain onset and offset-2 sensory events opposing valences.Thirty-eight (mean ± SD age...
The cerebellum, a structure historically associated with motor control, has more recently been implicated in several higher-order auditory-cognitive functions. However, the exact functional pathways that mediate cerebellar influences on auditory cortex (AC) remain unclear. Here, we sought to identify cortico-cerebellar based intrinsic connectivity magnetic resonance imaging. In contrast previous studies principally consider AC as single functionally homogenous unit, mapped across different...