A5100626123- Hair Growth and Disorders
- Dermatology and Skin Diseases
- Analytical Chemistry and Chromatography
- Polyamine Metabolism and Applications
- Parkinson's Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Amino Acid Enzymes and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Mass Spectrometry Techniques and Applications
- melanin and skin pigmentation
- Drug Transport and Resistance Mechanisms
- Analytical Methods in Pharmaceuticals
- Cannabis and Cannabinoid Research
- Skin and Cellular Biology Research
- Immune cells in cancer
- Inflammatory mediators and NSAID effects
- Phytoestrogen effects and research
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Berberine and alkaloids research
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Toxic Organic Pollutants Impact
- Pesticide Residue Analysis and Safety
- Hormonal and reproductive studies
Kyung Hee University
2016-2025
Center for Neurologic Study
2015
Goethe University Frankfurt
2009
Ministry of Food and Drug Safety
2008
Kyungpook National University
2008
Anhui Agricultural University
2003
ABSTRACT: Isoflavones and their glycosides were isolated from kudzu root, formononetin‐7‐ O ‐glucoside (ononin) was identified the plant for first time. Among compounds, antioxidant potency of 5 major compounds determined using (1) 2,2‐diphenyl‐1‐picrylhydrazyl free‐radical scavenging assay, (2) thiocyanate assay in linoleic acid model system, (3) lipoxygenase inhibition assay. The study indicates that act as scavengers inhibit both peroxidation activity. 3 different assays determining...
RATIONALE Alkaloids with significant therapeutic effects are the main active constituents of Corydalis ( C .) species. There several kinds alkaloids in . species associated diverse alkaloid metabolism plants, but they rarely identified. This study aimed to identify by liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI‐MS/MS). METHODS Several types were extracted from using ultrasonication 70% CH 3 OH, and extract was partitioned at pH 2 12. Separation achieved C18...
L. has been widely used by humans for centuries various purposes, such as industrial, ceremonial, medicinal, and food. The bioactive components of
ABSTRACT Pseudomonas aeruginosa is an opportunistic human pathogen that causes both acute and chronic infections due to its virulence factors, biofilm formation the ability suppress host immune system. Quorum sensing (QS) plays a key role in regulating these pathogenic traits also downregulates expression of peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) cells. In this study, we isolated two novel natural products from jellyfish‐derived fungus Penicillium chermesinum ,...
Abstract Background Increased attention to gastrointestinal ( GI ) symptoms and disease‐specific contexts may play an important role in the enhanced perception of visceral stimuli frequently reported patients with irritable bowel syndrome IBS ). In this study, we test hypothesis that altered attentional mechanisms underlie central pain amplification . Methods To evaluate brain networks support alerting, orienting, executive attention, employed network ANT ), a modified flanker task which...
Chrysanthemum boreale is a plant widespread in East Asia, used folk medicine to treat various disorders, such as pneumonia, colitis, stomatitis, and carbuncle. Whether the essential oil from C. (ECB) its active constituents have anti-proliferative activities lung cancer unknown. Therefore, we investigated cytotoxic effects of ECB A549 NCI-H358 human cells. Culture cells with induced apoptotic cell death, revealed by an increase annexin V staining. treatment reduced mitochondrial membrane...
Abstract Decarboxylation of cannabidiolic acid (CBDA) is an important step for efficient production the active pharmaceutical component cannabidiol (CBD) in Cannabis species. Acidic cannabinoids (ACBs) can be easily transformed into neutral via loss carbon dioxide when exposed to heat. During thermal process, several products including psychotropic △ 9 -tetrahydrocannabinol ( -THC) and its isomers were produced through decarboxylation, hydration, isomerization, oxidation, as identified by...
Abstract: Previous reports have suggested that the herbal medicine Chunghyuldan (CHD, Qingxue‐dan in Chinese and Daio‐Orengedokuto Japanese) has wide‐ranging biological effects, including anti‐hyperlipidaemic, anti‐ischaemic, anti‐inflammatory antioxidant activities. Reactive oxygen species (ROS)‐mediated mitochondrial dysfunction is thought to be one of major pathological mechanisms responsible for Parkinson’s disease (PD) may underlie selective loss dopaminergic neurons substantia nigra...
Angelica sinensis (AS) is one of the most popular medicinal foods used as a hematopoietic herb and also traditionally applied topically for skin disorders. However, effectiveness AS on atopic dermatitis (AD) has not been reported yet. This study was conducted to evaluate antipruritic anti-inflammatory effects regulating AD-related mediators in DNCB (2,4-dinitrochlorobenzene)-induced mice. dorsal DNCB-challenged mice 11 days. Alteration thickness measured assessment histological improvement....
Although Parkinson's disease (PD) is a representative neurodegenerative disorder and shows characteristic motor impediments, the pathophysiological mechanisms treatment targets for PD have not yet been clearly identified. Since several tryptophan metabolites produced by gut microbiota could pass blood-brain barrier and, furthermore, might influence central nervous system, within indole, kynurenine, serotonin metabolic pathways be most potent development. Furthermore, are circulated via...
The demand for novel three-dimensional (3D) cell culture models of adipose tissue has been increasing, and proteomic investigations are important determining the underlying causes obesity, type II diabetes, metabolic disorders. In this study, we performed global quantitative profiling three 3D-cultured 3T3-L1 cells (preadipocytes, adipocytes co-cultured with macrophages) their 2D-cultured counterparts using 2D-nanoLC-ESI-MS/MS iTRAQ labelling. A total 2,885 shared proteins from six types...
Aims There are many obstacles to overcome in the development of new drugs for metabolic diseases, including efficacy and toxicity problems later stages drug development. To these predict early stages, we constructed a model insulin resistance terms communication between 3T3‐L1 adipocytes RAW264.7 macrophages by three‐dimensional (3D) culture. Results In this study, results focused on functional resemblance 3D co–culture adipose tissue diabetic mice. The mono–culture preadipocytes showed good...
Hair loss is accompanied by keratinocyte apoptosis-regression during catagen and prolonged telogen. Angelica sinensis was reported to promote hair growth in vitro. Based on previous studies, we explored the effect mechanism of A. related mice. The 70% Ethanol extract applied topically at doses 1 100 mg/mL dorsa C57BL/6 mice for 2 weeks. sinensis-treated group showed noticeable regrowth. Treatment with restored lengths shafts size follicles. In addition, treated notably decreased apoptotic...