A5103234590- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Gut microbiota and health
- Electromagnetic Fields and Biological Effects
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Prion Diseases and Protein Misfolding
- Immunotherapy and Immune Responses
- Cardiovascular Conditions and Treatments
- Laser Applications in Dentistry and Medicine
- Clostridium difficile and Clostridium perfringens research
- Vascular anomalies and interventions
- Viral gastroenteritis research and epidemiology
- Veterinary Oncology Research
- Pluripotent Stem Cells Research
- Magnetic and Electromagnetic Effects
- Salivary Gland Tumors Diagnosis and Treatment
- Infectious Diseases and Mycology
- Asthma and respiratory diseases
- Nerve injury and regeneration
- Systemic Lupus Erythematosus Research
- Inflammation biomarkers and pathways
- Genomics, phytochemicals, and oxidative stress
- Geomagnetism and Paleomagnetism Studies
- Supramolecular Self-Assembly in Materials
Hankyong National University
2014-2025
Yonsei University
2017-2022
The Schwarzman Animal Medical Center
2020
Soongsil University
2010-2018
Chungnam National University
2017
Abstract Interleukin 33 (IL-33) that signals through the ST2 receptor has emerged as a critical modulator in several inflammatory disorders, including bowel disease (IBD). However, precise mechanisms by which IL-33 modulates IBD are controversial. The aim of this study was thus to clarify role IBD. plasma levels were significantly decreased, but soluble increased patients with compared healthy individuals. Moreover, restored goblet cell numbers and induced macrophage switching from M1 M2...
Life on Earth is constantly exposed to natural electromagnetic fields (EMFs), and it generally accepted that EMFs may exert a variety of effects biological systems. Particularly, extremely low-frequency (EL-EMFs) affect processes such as cell development differentiation; however, the fundamental mechanisms by which influence these remain unclear. Here we show EMF exposure induces epigenetic changes promote efficient somatic reprogramming pluripotency. These resulted from EMF-induced...
Nuclear factor kappa B (NF-κB) activation and endoplasmic reticulum (ER) stress signaling play significant roles in the pathogenesis of inflammatory bowel disease (IBD). Thus, we evaluated whether new therapeutic probiotics have anti-colitic effects, investigated their mechanisms related to NF-κB ER-stress pathways.Luciferase, nitric oxide, cytokine assays using HT-29 or RAW264.7 cells were conducted. Mouse colitis was induced dextran sulfate sodium confirmed by activity index histology....
Abstract Microbial dysbiosis has long been postulated to be associated with the pathogenesis of inflammatory bowel disease (IBD). Although evidence supporting anti-colitic effects melatonin have accumulating, it is not clear how affects microbiota. Herein, we investigated on microbiome in colitis and identified involvement Toll-like receptor (TLR) 4 signalling effects. Melatonin improved dextran sulfate sodium (DSS)-induced reverted microbial wild-type (WT) mice but TLR4 knockout (KO) mice....
Lactobacillus plantarum has been identified as a probiotic bacterium owing to its role in immune regulation and maintenance of intestinal permeability. Here, we investigated the anti-colitic effects mechanism L. CBT LP3 (LP3). This vivo study was performed using dextran sodium sulfate (DSS) induce colitis mice. Mice were randomly divided into three groups: control supplied with normal drinking water, DSS-treated group followed by oral administration vehicle, gavaged daily for 7 days...
Abstract PKMYT1, a serine/threonine kinase, selectively regulates CDK1 during the G2/M phase transition to prevent mitotic entry in presence of DNA damage, whereas WEE1 kinase both and CDK2. Inhibition PKMYT1 forces cancer cells prematurely enter mitosis without repairing thereby leading cell death. Therefore, is an attractive target for synthetic lethality damage-sensitive cells, such as those with hyperactive CCNE1/CDK2 signaling p53 mutations. CCNE1 amplification (Copy number ≥ 6)...
Abstract Tumors with BRCA1/2 mutations demonstrate homologous recombination (HR) repair deficiencies, leading to genomic instability. Genomic instability is a defining hallmark of numerous carcinomas, making them susceptible therapies targeting the DNA damage response (DDR) pathways. Among these, poly (ADP-ribose) polymerase (PARP) inhibitors have shown representative therapeutic options. However, incomplete disease control and emergence resistance remain challenges for many patients....
The purpose of this study was to investigate the effect Schwann-like cells combined with pulsed electromagnetic field (PEMF) on peripheral nerve regeneration. were derived from human dental pulp stem (hDPSCs) and verified CD104, S100, glial fibrillary acidic protein (GFAP), laminin, P75NTR immunocytochemistry. Gene expression S100 analyzed. Male Sprague-Dawley rats (200-250g, 6-week-old) divided into seven groups (n = 10 each): control, sham, PEMF, hDPSCs, hDPSCs + cells, PEMF. Cells...
Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by prolonged inflammation of the gastrointestinal tract. IBD can result from gut barrier dysfunction, altered microbiota, and abnormal intestinal immunity induced environmental factors in genetically susceptible individuals. Proton pump inhibitors (PPIs) such as rabeprazole are frequently employed for gastric acid inhibition. However, long-term PPI administration alter microbiome composition, possibly...
Here, we identify cells within human adult secondary lymphoid tissues that are comparable in phenotype and location to the tissue inducer (LTi) persist mouse. Identified as CD117(+) CD3(-) CD56(-) cells, like murine LTi they lack expression of many common lineage markers express CD127, OX40L TRANCE. These were detected at interface between B- T- zones, well subcapsular sinus LNs, where reside spleen LNs. Furthermore, these expressed high levels IL-22 upregulated upon IL-23 stimulation....
The purpose was to clarify the influence of frequency and exposure time pulsed electromagnetic fields (PEMF) on peripheral nerve regeneration.Immortalized rat Schwann cells (iSCs) (1 × 10(2)/well) were exposed at four different conditions in 1 mT (50 Hz h/d, 50 12 150 h/d 12h/d). Cell proliferation, mRNA expression S100 brain-derived neurotrophic factor (BDNF) analyzed. Sprague-Dawley rats (200-250 g) divided into six groups (n = 10 each): control, sham, Hr/d. Mental crush-injured Hr/d,...
The enzyme glutathione S-transferase theta 1 (GSTT1) is involved in detoxifying chemicals, including reactive oxygen species (ROS). Here, we provide a significant insight into the role of GSTT1 inflammatory bowel disease (IBD). We identified decreased expression inflamed colons from IBD patients compared to controls. intrarectally or intraperitoneally delivered Gstt1 gene mice with dextran sodium sulfate (DSS)-induced colitis and noted attenuation through transfer via an IL-22 dependent...
In this study, we compared the immune cell populations in rheumatoid arthritis (RA) synovial fluid, which shows lymphoid tissue-like structure, with those tonsils, are normal secondary tissues. Firstly, found that CD4(-)CD11b(+) macrophages were major population RA fluid and B cells tonsils. addition, from patients osteoarthritis, is a degenerative joint disease, contained CD4(+)CD11b(+) monocytes as population. Secondly, categorized three groups based on proportion of fluid: (1)...
Triggering receptor expressed on myeloid cell-1 (TREM-1) signaling is neutrophils and monocytes that necessary for the successful antimicrobial response resolution of inflammation in gut. In this study, we determined effect an anti-TREM-1 agonistic antibody (α-TREM-1) colitis identify its underlying mechanism action. Administration α-TREM-1 alleviated mice resolved dysbiosis, which required TLR4/Myd88 signaling. increased production neutrophil extracellular traps interleukin-22 by CD177 +...
The purpose of this study was to determine whether crush injured rat sciatic nerve could be benefit from pulsed electromagnetic field (PEMF) combined with human dental pulp stromal cells (hDPSCs), FK506 (Tacrolimus) for immune suppression and neuropromotion.Male Sprague-Dawley rats (200-250 g, 6 week old) were distributed into groups (n = 18 each): control, PEMF, FK506, PEMF + hDPSCs, hDPSCs groups. (cell 1 × 106/10 μl/rat) injected at the site immediate after injury. administered 3 weeks in...
Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) has been proposed as a novel regulator of adaptive immune homeostasis through modulating T cell polarization. Thus, DYRK1A could present potential target in autoimmune disorders. Here, we identify FRTX-02 compound exhibiting potent and selective inhibition DYRK1A. induced transcriptional activity the substrate NFAT lines. Correspondingly, promoted ex vivo CD4+ polarization into anti-inflammatory Tregs reduced their...
ZYM-201 is a methyl ester of triterpenoid glycoside from Sanguisorba officinalis which has been used for treatment inflammatory and metabolic diseases. In this study, immunomodulatory effects on B cells were examined in vitro vivo. When splenocytes activated with lipopolysaccharide (LPS), the major population had shown an increase cell numbers was cells. However, when treated after LPS activation, their expression costimulatory molecules, CD80 CD86, decreased. Furthermore, effect LPS,...
Toll-like receptors (TLRs), which recognize structurally conserved components among pathogens, are mainly expressed by antigen-presenting cells such as dendritic (DCs), B cells, and macrophages. Recognition through TLRs triggers innate immune responses influences antigen-specific adaptive responses. Although studies on the expression functions of in have been extensively reported, lymphoid tissue inducer (LTi) limited. In this study, we observed that LTi TLR2 TLR4 mRNA well protein...