A5043382733- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Lung Cancer Research Studies
- Traumatic Brain Injury Research
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Neurosurgical Procedures and Complications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Intracranial Aneurysms: Treatment and Complications
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Augmented Reality Applications
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Management of metastatic bone disease
- Mesenchymal stem cell research
- Economic and Environmental Valuation
- Anatomy and Medical Technology
- Agriculture, Soil, Plant Science
- Histone Deacetylase Inhibitors Research
- Surgical Simulation and Training
Ajou University
2015-2024
Ajou University Hospital
2014-2024
Institut Pasteur Korea
2018-2020
Institut Pasteur
2020
Sungkyunkwan University
2014
Hallym University Medical Center
2014
St. Paul's Hospital
2011
St. Vincent's Hospital
2011
Gangnam Severance Hospital
2011
Yonsei University
2011
The incidence and risk factors for recurrence after endovascular treatment of intracranial vertebrobasilar dissecting aneurysms (VBDAs) have not been studied. We aimed to evaluate the VBDAs.A total 111 patients (mean age, 45±10 years) underwent 119 VBDAs (ruptured/unruptured=73:46). Incidence were retrospectively evaluated.Sixty-two treated by a reconstructive technique using 1 3 overlapping stents with or without coiling, 57 deconstructive proximal occlusion internal trapping at dissected...
Object The aim of this study was to determine the risk factors associated with development postoperative ischemic complications after surgical revascularization used treat pediatric patients moyamoya disease. Methods clinical, imaging, and perioperative data from 170 procedures in 90 children who underwent indirect surgery were retrospectively reviewed. To clarify factors, cases identified those without such events compared. For study, a complication defined as newly developed infarction...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and has poor prognosis. Specially, patients with HCC usually have tolerance systemic chemotherapy, because HCCs develop from chronically damaged tissue that contains considerable inflammation, fibrosis, cirrhosis. Since exhibits highly heterogeneous molecular characteristics, a proper in vitro system required for study pathogenesis. To this end, we established two new hepatitis B virus (HBV) DNA-secreting...
OBJECTIVE Virtual reality (VR) is increasingly being used for education and surgical simulation in neurosurgery. So far, the 3D sources VR have been derived from medical images, which lack real color. The authors made photographic models dissected cadavers integrated them into platform. This study aimed to introduce a method of developing photograph-integrated evaluate educational effect these models. METHODS A silicone-injected cadaver head was prepared. CT scan specimen taken, soft tissue...
Glioblastoma (GBM) has a poor prognosis after standard treatment. Recently, metformin been shown to have an antitumor effect on glioma cells. We performed the first randomized prospective phase II clinical trial investigate efficacy and safety of in patients with recurrent or refractory GBM treated low-dose temozolomide.Included were randomly assigned control group [placebo plus temozolomide (50 mg/m2, daily)] experimental [metformin (1000 mg, 1500 2000 mg per day during 1st, 2nd, 3rd week...
Purpose To determine whether semiquantitative histogram analysis of the normalized cerebral blood volume (CBV) for an entire contrast material–enhanced lesion could be used to predict fraction posttreatment high-grade glioma recurrence compared with change. Materials and Methods The institutional review board approved this retrospective study. Informed consent was obtained. Thirty-nine patients pathologically proved predominant tumor (tumor group, ≥50% [n = 14]), mixed change (mixed ≥20%...
Purpose Homeobox (HOX) genes are essential developmental regulators that should normally be in the silenced state an adult brain. The aberrant expression of HOX has been associated with prognosis many cancer types, including glioblastoma (GBM). This study examined identity and role affecting GBM treatment resistance. Materials Methods full series five pairs initial recurrent human samples were screened by microarray analysis to determine most plausible candidate responsible for prognosis....
Chemotherapy used for patients with unresectable lung tumors remains largely palliative due to chemoresistance, which may be tumor heterogeneity. Recently, multiple studies on the crosstalk between cancer cells and their microenvironment (TME) have been conducted understand overcome chemoresistance in cancer.In this study, we investigated effect of reciprocal vascular endothelial using multicellular spheroids (MCTSs) containing HUVECs.Secretomes from significantly triggered...
Abstract Hepatocellular carcinoma (HCC), one of the most common malignant cancers worldwide, is associated with substantial mortality. Because HCCs have strong resistance to conventional chemotherapeutic agents, novel therapeutic strategies are needed improve survival in patients HCC. The multicellular tumor spheroid (MCTS) model a powerful method for anticancer research because its ability mimic complexity and heterogeneity tissue, three-dimensional cellular context pathophysiological...
There is a strong association between intracranial hypertension (IH) that occurs following the acute phase of traumatic brain injury (TBI) and negative outcomes. This study proposes pressure-time dose (PTD)-based parameter may specify possible serious IH (SIH) event develops model to predict SIH. The minute-by-minute signals arterial blood pressure (ABP) (ICP) 117 TBI patients were utilized as internal validation dataset. SIH was explored through prognostic power variables for outcome after...
Abstract Genomic alterations in tumors play a pivotal role determining their clinical trajectory and responsiveness to treatment. Targeted panel sequencing (TPS) has served as key tool over the past decade, but advancements costs bioinformatics have now made whole-genome (WGS) feasible single-assay approach for almost all cancer genomes settings. This paper reports on findings of prospective, single-center study exploring real-world utility WGS (tumor matched normal tissues) two primary...
To evaluate the prognostic value of volume residual viable tumor versus therapy-induced necrosis in resection material and diagnostic ancillary tests recurrent glioblastoma (GBM), we conducted a retrospective review 20 patients whose initial specimens were available. Recurrent GBMs graded according to extent histopathologic parameters: with high-grade, non-high-grade, pure high-grade components therapy-related necrosis. We also examined MIB-1 labeling, isocitrate dehydrogenase 1 mutation,...
To study the clinical significance and relevant factors of radiation-induced intratumoral necrosis (RIN) peritumoral edema (PTE) after Gamma knife radiosurgery (GKRS) for intracranial meningiomas.We retrospectively analyzed data 64 patients who underwent GKRS meningioma. The mean lesion volume was 4.9 cc (range, 0.3-20), prescription dose 13.4 Gy 11-18) delivered to 49.9% 45-50) isodose line. RIN defined as newly developed or enlarged GKRS.RIN new development aggravation PTE were observed in...
Objective:The beneficial effect of decompressive craniectomy in the treatment severe traumatic brain injury (TBI) is controversial, but there no debate that decompression should be performed before irreversible neurological deficit occurs.The aim our study was to assess value ultra-early patients with TBI.Methods: Total 127 who underwent from January 2007 December 2013 included this study.Among them, 60 had (within 4 hours injury) emergent operation for relief increased intracranial...
There has been no practical guidelines for the management of patients with central nervous system (CNS) tumors in Korea many years. Thus, Korean Society Neuro-Oncology (KSNO), a multidisciplinary academic society, started to prepare CNS from February 2018.The Working Group was composed 35 medical experts Korea. References were identified through searches PubMed, MEDLINE, EMBASE, and Cochrane CENTRAL using specific sensitive keywords as well combinations keywords.First, maximal safe resection...
For treating recurrent glioblastoma, for which there is no established treatment, the antiangiogenic antibody, bevacizumab, used alone or with irinotecan. This study was aimed at comparing survival of patients glioblastoma receiving bevacizumab monotherapy and those plus irinotecan combination therapy (B+I) by using a nationwide population-based dataset.