A5052806512- Cell Adhesion Molecules Research
- Gastric Cancer Management and Outcomes
- Glycosylation and Glycoproteins Research
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Viral-associated cancers and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cancer Mechanisms and Therapy
- Proteoglycans and glycosaminoglycans research
- Chromatin Remodeling and Cancer
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- Neurofibromatosis and Schwannoma Cases
- Gallbladder and Bile Duct Disorders
Ajou University
2016-2025
Virginia Commonwealth University
2024
Ajou University Hospital
2014-2018
Kyungpook National University Hospital
2011-2014
Kyungpook National University
2011-2014
Samsung Medical Center
2006-2011
Sungkyunkwan University
2006-2011
Although the tumor stroma in solid tumors like gastric cancer (GC) plays a crucial role chemo-resistance, specific targets to inhibit interaction between stromal and cells have not yet been utilized clinical practice. The present study aims determine whether cancer-associated fibroblasts (CAFs), major component of stroma, confer chemotherapeutic resistance GC cells, discover potential improve chemo-response GC. To identify CAF-specific proteins signal transduction pathways affecting...
Abstract Nicotinamide phosphoribosyltransferase (NAMPT) is a metabolic enzyme with key roles in inflammation. Previous studies have examined the consequences of its upregulated expression cancer cells themselves, but are limited respect to role other within tumor microenvironment (TME) during colorectal (CRC) progression. Using single‐cell RNA sequencing (scRNA‐seq) data, it founded that NAMPT highly expressed SPP1 + tumor‐associated macrophages (TAMs), unique subset TAMs associated...
Abstract Background Necroptosis is emerging as a new target for cancer immunotherapy it now recognized form of cell death that increases tumor immunogenicity, which would be especially helpful in treating immune-desert tumors. De novo synthesis inflammatory proteins during necroptosis appears important facilitating increased anti-tumor immune responses. While late-stage transcription mediated by NF-κB believed to play role this process, otherwise unclear what signaling events initiate...
Notwithstanding remarkable treatment success with anti‐PD‐1 monoclonal antibody, oncogenic mechanism of PD‐L1 regulation in gastric cancer (GC) remains poorly understood. We hypothesized that ARID1A might be related to tumor expression GC. found positivity was associated loss and showed trend toward better survival patients various molecular subtypes GC (experimental set, n = 273). Considering heterogeneous expression, we validated this using whole tissue sections (n 159) correlated...
Oncogenic RAS mutant (RASMUT) proteins have been considered undruggable via conventional antibody regimens owing to the intracellular location restricting conventional-antibody accessibility. Here, we report a pan-RAS-targeting IgG antibody, inRas37, which directly targets intracellularly activated form of various RASMUT subtypes after tumor cell-specific internalization into cytosol block interactions with effector proteins, thereby suppressing downstream signaling. Systemic administration...
Discoidin domain receptor 1 (DDR1), a tyrosine kinase that utilizes collagen as ligand, is key molecule in the progression of solid tumors it regulates interaction cancer cells with tumor stroma. However, clinical relevance DDR1 expression gastric carcinoma yet to be investigated. Here, we assessed role mediating aggressive phenotype and its potential therapeutic target.We conducted immunohistochemistry using tissue microarray 202 specimens. We examined effect collagen-induced activation on...
The At-rich interactive domain 1A (ARID1A) is frequently mutated in gastric cancers (GCs) with a poor prognosis. Growing evidence indicates that loss of ARID1A expression leads to activation the phosphatidylinositol 3-kinase (PI3K)/AKT pathway by AKT phosphorylation. We aim investigate different sensitivity for inhibitor ARID1A-deficient GC cells.After transfection using siRNA or shRNA, effect knockdown on PI3K/AKT signaling was evaluated Western blot analysis. ARID1A-knockdown cells were...
Discoidin domain receptor 1 (DDR1) is activated by fibrillar (triple-helical) collagens and collagen IV, which are major components of tumor stroma; thus, DDR1 might be a critical mediator communication between cancer cells stroma. The aim this study was to investigate the effect inhibition on stroma-induced peritoneal metastasis in gastric carcinoma. We analyzed immunohistochemistry correlation expression pattern recurrence carcinoma tissues from previously characterized established patient...
Protein tyrosine phosphatase receptor delta (PTPRD) is frequently inactivated in various types of cancers. Here, we explored the underlying mechanism PTPRD-loss-induced cancer metastasis and investigated an efficient treatment option for PTPRD-inactivated gastric cancers (GCs).PTPRD expression was evaluated by immunohistochemistry. Microarray analysis used to identify differentially expressed genes cells. Quantitative reverse transcription (qRT-PCR), western blotting, and/or enzyme-linked...
Necroptosis plays a crucial role in the progression of various diseases and has gained substantial attention for its potential to activate antitumor immunity. However, complex signaling networks that regulate necroptosis have made it challenging fully understand mechanisms translate this knowledge into therapeutic applications. To address these challenges, an optogenetically activatable system is developed allows precise spatiotemporal control key regulators, bypassing upstream processes....
Background BRAF mutation has received a great deal of attention in neuro‐oncology field, recently. This study aimed to investigate the incidence and clinical significance V600E low‐grade glial tumors. Methods An institutional cohort 105 brain tumors (51 dysembryoplastic neuroepithelial (DNTs), 14 subependymal giant cell astrocytomas (SEGAs), 12 glioblastoma with neuronal marker expression (GBM‐N), 28 pleomorphic xanthoastrocytomas (PXAs)) from 100 patients were investigated for presence by...
Biopsy needles have recently been developed to obtain both cytological and histological specimens during endoscopic ultrasound (EUS). We conducted this study compare 22-gauge (G) fine needle aspiration (FNA) needles, which the most frequently used, new 25G biopsy (FNB) for EUS-guided sampling of solid pancreatic masses. a retrospective cohort all performed between June 2010 October 2013. During period, 76 patients with masses underwent 22G FNA (n = 38) or FNB diagnosis. An on-site...
Prognostic Stratification by Extramural Depth of Tumor Invasion Primary Rectal Cancer Based on the Radiological Society North America ProposalSeung Hyun Cho1, Seung Ho Kim2, Ji Hea Bae3, Yun-Jin Jang3, Hye Jung Kim1, Dakeun Lee4,5 and Jun Seok Park6Audio Available | Share
Tumor-promoting inflammation is a hallmark of cancer and highly associated with tumor progression, angiogenesis, metastasis. Tumor-associated macrophages (TAMs) are major drivers tumor-promoting inflammation, but due to the complexity microenvironment, detailed regulatory mechanisms still under investigation. Here, we investigated novel role for transglutaminase 2 (TGM2) in development recruitment TAMs gastric (GC) tissues. When estimated by array comparative genomic hybridization droplet...
Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD
Recent studies have demonstrated that acetyl-CoA synthetase 2 (ACSS2) plays a critical role in cancer cell survival; however, the of ACSS2 gastric carcinogenesis has not been determined.We investigated expression human (GC) tissues using immunohistochemistry, and analyzed its clinicopathological correlation prognostic relevance.Among 350 GCs, 219 cases (62.6%) were classified as ACSS2-low, whereas 131 (37.4%) ACSS2-high. Loss (ACSS2-low) was more frequently observed undifferentiated...
Pancreatic cancer is a devastating disease and highly resistant to anticancer drugs because of its complex microenvironment. Cancer-associated fibroblasts (CAFs) are an important source extracellular matrix (ECM) components, which alter the physical chemical properties pancreatic tissue, thus impairing effective intratumoral drug delivery resulting in resistance conventional chemotherapy. The objective this study was develop new organoid model, including fibrous tumor microenvironment (TME)...
Abstract Genomic alterations in tumors play a pivotal role determining their clinical trajectory and responsiveness to treatment. Targeted panel sequencing (TPS) has served as key tool over the past decade, but advancements costs bioinformatics have now made whole-genome (WGS) feasible single-assay approach for almost all cancer genomes settings. This paper reports on findings of prospective, single-center study exploring real-world utility WGS (tumor matched normal tissues) two primary...
Mutations in isocitrate dehydrogenase 1 (IDH1) are found a high proportion of glial tumors and have significant prognostic impact. Although direct sequencing has been considered to be the gold-standard method detect this mutation, sensitivity technique questioned especially because specimens from may contain large numbers non-tumor cells. We screened 141 cases oligodendroglial for IDH1 mutations using peptide nucleic acid (PNA)-mediated clamping polymerase chain reaction (PCR) compared...