Glycogen biogenesis and its response to physiological stimuli have often been implicated in age-related diseases. However, their direct relationships cell senescence aging not clearly elucidated. Here, we report the central involvement of enhanced glycogenesis cellular senescence. accumulation, glycogen synthase (GS) activation, kinase 3 (GSK3) inactivation commonly occurred diverse models, including liver tissues F344 rats. Subcytotoxic concentrations GSK3 inhibitors (SB415286 LiCl) were...

C-X-C motif chemokine 9 (CXCL9), CXCL10, and CXCL11 are produced in response to interferon-γ (IFN-γ) trigger inflammation with the accumulation of activated lymphocytes. It appears that these chemokines could play a role pathogenesis adult-onset Still's disease (AOSD). Therefore, we investigated associations between levels clinical manifestations patients active AOSD. Serum IFN-γ, CXCL9, CXCL10 were determined using enzyme-linked immunosorbent assays. IFN-γ higher AOSD than rheumatoid...

Biopsy needles have recently been developed to obtain both cytological and histological specimens during endoscopic ultrasound (EUS). We conducted this study compare 22-gauge (G) fine needle aspiration (FNA) needles, which the most frequently used, new 25G biopsy (FNB) for EUS-guided sampling of solid pancreatic masses. a retrospective cohort all performed between June 2010 October 2013. During period, 76 patients with masses underwent 22G FNA (n = 38) or FNB diagnosis. An on-site...

The aim of this study was to test the hypothesis that apoptosis can protect against experimental pancreatitis and induction by an extract Artemisia asiatica (DA-9601) is beneficial in cerulein-induced pancreatis rats. Pancreatitis induced 6-week-old male SPF Sprague-Dawley rats two intravenous (i.v.) administrations 40 microg/kg cerulein. To investigate effects DA-9601 on severity extent apoptosis, were treated with intragastric DA-9601, 30 mg/kg (D30), 100 (D100), or 300 (D300),...

The purpose of this study was to evaluate sonographic findings breast papillary lesions and the effectiveness American College Radiology Breast Imaging Reporting Data System assessment system for differentiation benign malignant lesions.We retrospectively reviewed 46 surgically proven papillomas 22 carcinomas. All images patients were interpreted by 2 radiologists. Sonographic analyzed according classification.The shape lesion round or oval in 33 (71.7%) 13 carcinomas (61.9%). As margin, a...

The purpose of this study was to compare adjacent vessel sign, increased ipsilateral whole-breast vascularity, and various MRI features as described in the American College Radiology BI-RADS lexicon with histopathologic predictors patients unilateral breast cancer.We retrospectively evaluated examinations 249 histologically confirmed cancer. In addition lexicon, sign vascularity cancer-bearing were by two independent observers. then correlated prognostic factors.The significantly (p=0.023...

Adult-onset Still disease (AOSD) is characterized by fever, skin rash, and lymphadenopathy with leukocytosis anemia as common laboratory findings. We investigated the characteristic pathologic findings of skin, lymph node, liver, bone marrow to assist in proper diagnosis AOSD. Forty AOSD patients were included study. The (26 patients), node (8 liver or biopsies (22 patients) between 1998 2013 retrospectively analyzed. diagnosed according Yamaguchi criteria after excluding infections,...

S100A8/A9 has been suggested as a marker of disease activity in patients with adult-onset Still's (AOSD). We evaluated the clinical significance biomarker and its pathogenic role AOSD. Blood samples were collected prospectively from 20 AOSD healthy controls (HCs). Furthermore, skin lymph node biopsy specimens investigated for expression levels via immunohistochemistry. Peripheral blood mononuclear cells (PBMCs) active HCs cell signals. S100A8/A9, interleukin-1β (IL-1β), tumor necrosis...

The allergic response to common environmental agents (allergens) has been regarded as an important mechanism in the development of airway inflammation patients with asthma. However, sensitization cannot be detected a significant number adult etiologic responsible for nonallergic asthma not yet identified. idea possible involvement autoimmunity pathogenesis proposed by earlier studies. To test presence autoimmune bronchial epithelial cell antigens asthma, we examined circulating...

Kidney Transplantation from a Donor Following Cardiac Death Supported with Extracorporeal Membrane OxygenationTo expand the donor pool, organ donation after cardiac death (DCD) has emerged.However, kidneys DCD donors have period of long warm ischemia between arrest and harvesting organs.Recently, we used extracorporeal membrane oxygenation (ECMO) to minimize ischemic injury during ´no touch´ periods in Maastricht category II performed two successful kidney transplantations.The were procured...

Significantly lower endogenous expression of B‐cell translocation gene 2 ( BTG 2) was observed in human muscle‐invasive bladder cancers MIBC ) than matched normal tissues and non‐muscle invasive NMIBC ). inversely correlated with increased the DNA methyltransferases DNMT 1 3a , but not suggesting a potential role for muscle invasion cancer. Over 90% tumor revealed strong methylation at CpG islands gene, compared no tissues, implying epigenetic regulation carcinogenesis. By using EJ cancer...

Systemic lupus erythematosus (SLE) is a typical autoimmune disease that's characterized by various autoantibodies to nuclear and cytoplasmic antigens. The presence of antinuclear antibodies (ANA) in serum generally considered decisive diagnostic sign SLE. However, small subset SLE patients who had the clinical features was reported show persistently negative ANA tests. Our report describes 16-yr-old female presented with manifestations such as malar rash, photosensitivity, arthritis,...

To assess whether polysaccharides isolated from fungi, Phellinus spp, could reduce the adhesion and abscess formation in a rat peritonitis model.Although spp is well-known material with antiinflammatory properties, little known regarding its ability to prevent intraperitoneal adhesions. We have assessed adhesion- abscess-reducing effect of gilvus (PG) linteus (PL) model.In 60 SD rats, experimental was induced using cecal ligation puncture model (CLP). Animals were randomly assigned 5 groups;...

We evaluated the utility of VE1 antibody that can detect a mutant protein resulting from BRAF V600E mutation as diagnostic tool for thyroid fine-needle aspiration cytology (FNAC).We performed immunocytochemistry on 202 FNAC specimens surgically confirmed nodules. The results were compared with molecular analyses in these matched their corresponding histology.Diagnoses included benign (9.4%), atypia undetermined significance/follicular lesion significance (11.4%), follicular...

Background/Aim: The aim of this study was to investigate the association between lymphopenia after breast conserving therapy (BCT) and ipsilateral tumor recurrence (IBTR) in early cancer (EBC). Patients Methods: We examined 216 EBC patients treated with partial mastectomy followed by radiotherapy (RT), none whom received chemotherapy. Absolute lymphocyte counts (ALCs) during two years RT were collected from each patient: pretreatment ALC, ALC at 3-5 months (ALC1), 9-11 months, 15-17 21-23...

Objectives The purposes of this study were to assess the clinical utility sonography for evaluation contralateral suspicious lesions detected on magnetic resonance imaging (MRI) in patients with breast cancer and compare findings index synchronous cancers. Methods We performed MRI 853 consecutive histologically confirmed between January 2006 December 2009. All underwent mammography whole-breast before MRI. included 126 enhancing 98 who second-look sonography. Lesions sonographic correlation...