A5100637497- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Thyroid Disorders and Treatments
- Advanced Radiotherapy Techniques
- Growth Hormone and Insulin-like Growth Factors
- Air Quality Monitoring and Forecasting
- BRCA gene mutations in cancer
- Sympathectomy and Hyperhidrosis Treatments
- Transportation Planning and Optimization
- Dermatologic Treatments and Research
- Radiation Therapy and Dosimetry
- S100 Proteins and Annexins
- Cancer-related Molecular Pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Laser Applications in Dentistry and Medicine
- Urban Transport and Accessibility
- Cancer-related molecular mechanisms research
- Lymphatic Disorders and Treatments
- Wastewater Treatment and Nitrogen Removal
- Medical Imaging Techniques and Applications
- Indoor Air Quality and Microbial Exposure
- Myasthenia Gravis and Thymoma
- Lymphatic System and Diseases
- Education, Safety, and Science Studies
Ajou University
2015-2024
Chungnam National University
2024
Wonkwang University
2024
Ajou University Hospital
2017-2022
Korea Electrotechnology Research Institute
2021
Pukyong National University
2011
Seoul National University
2009
Abstract Cellular senescence has been perceived as a barrier against carcinogenesis. However, the senescence-associated secretory phenotype (SASP) of senescent cells can promote tumorigenesis. Here, we show tumour are frequently present in front region collective invasion papillary thyroid carcinoma (PTC), well lymphatic channels and metastatic foci lymph nodes. In vitro analysis, exhibit high ability compared with non-senescent through SASP expression. Collective PTC is led by characterized...
Papillary thyroid microcarcinoma (PTMC) has been increasing, without a consensus for the management of this condition.In present study, we analyzed clinicopathological features patients with PTMC to examine impact initial therapy and establish appropriate treatment.A total 2,018 were enrolled at single university hospital.Of them, 1,245 (61.8%) underwent thyroidectomy, 1,838 (91.3%) central lymph node (LN) dissection.Five-and 10-yr recurrence rates 3.2% 4.6%, respectively.In univariate...
B-RafV600E oncogene mutation occurs most commonly in papillary thyroid carcinoma (PTC) and is associated with tumor initiation.However, a genetic modification by thyrocytes results oncogene-induced senescence (OIS).In the present study, we explored factors involved overcome program PTC.First of all, observed down-regulation p-extracellular signal-regulated kinases 1/2 up-regulation dual specific phosphatase 6 (DUSP6) PTC mutation.DUSP6 overexpression vitro induced extracellular...
B-RafV600E mutant is found in 40–70% of papillary thyroid carcinoma (PTC) and has an important role the pathogenesis PTC. The sodium iodide symporter (NIS) integral plasma membrane glycoprotein that mediates active transport into follicular cells, been known to be associated with loss NIS expression. In this study, we inhibited expression by upregulation its promoter methylation, specific regions CpG islands harboring PTC were highly methylated compared surrounding normal tissue. Although...
Abstract Background Congenital muscular torticollis (CMT) is characterized by thickening and/or tightness of the unilateral sternocleidomastoid muscle (SCM), ending up with torticollis. Our aim was to identify differentially expressed genes (DEGs) and novel protein interaction network modules CMT, discover relationship between gene expressions clinical severity CMT. Results Twenty-eight muscles (SCMs) from 23 subjects CMT 5 SCMs without were allocated for microarray, MRI, or...
We evaluated the utility of VE1 antibody that can detect a mutant protein resulting from BRAF V600E mutation as diagnostic tool for thyroid fine-needle aspiration cytology (FNAC).We performed immunocytochemistry on 202 FNAC specimens surgically confirmed nodules. The results were compared with molecular analyses in these matched their corresponding histology.Diagnoses included benign (9.4%), atypia undetermined significance/follicular lesion significance (11.4%), follicular...
Radiofrequency ablation (RFA) and ethanol (EA) are effective safe for benign symptomatic thyroid nodules (BSTNs). However, relatively little is known about the effects of these procedures on patients' quality life (QoL). This prospective, multicenter study evaluated RFA EA changes in thyroid-specific QoL patients with BSTNs assessed volume reduction safety procedures.Eighty-six consecutive 86 were prospectively included from two medical centers. was performed 55 solidity ≥50% 31 <50%. using...
BACKGROUND Thyroid-stimulating hormone (TSH), which is regulated by the negative feedback of triiodothyronine (T3) and thyroxine (T4), affected cortisol (a stress hormone) cytokines during allostasis. Thus, we assessed changes in TSH levels under its potential as a marker patients lacking T3 or T4 after thyroid surgery. MATERIAL AND METHODS Three questionnaires (Korean version Daily Stress Inventory, Social Readjustment Rating Scale, Overload Scale-Short [SOSS]), an open-ended questionnaire...
Studies investigating the correlation between particulate matter (PM) concentrations measured by a light scattering (LS) device and environmental factors are crucial to identify LS values with significant errors. Herein, relationship PM2.5 obtained through beta attenuation monitoring (BAM) was examined respect seven factors. Machine learning (ML) general statistical methods were employed reveal complex relationships. Data from five cities initially analyzed understand association BAM...
Purpose: Early intervention of surgical scars with a pulsed dye laser is known to effectively prevent pathologic scars.Despite multiple reports on the effectiveness treatment, very few studies have demonstrated its appropriate initiation timing.In this study, our objective was determine optimal timing for initiating treatment following thyroidectomy.Methods: This study retrospectively analyzed 91 patients undergoing post-thyroidectomy, grouping them by timing.The underwent at intervals 3-4...
Abstract Calcification is important for the diagnosis of papillary thyroid carcinoma (PTC). Runt-related transcription factor 2 (RUNX2), a master associated with osteogenic differentiation, reportedly related to PTC calcification and invasiveness. However, its regulatory role in this process somewhat uncharacterized. Here, we attempted identify genes that regulate RUNX2 clarify function carcinogenesis calcification. The expression RUNX2-upstream was evaluated by real-time PCR Nthy-Ori 3-1...
Recently, VE1, a monoclonal antibody against the BRAFV600E mutant protein, has been investigated in terms of its detection mutation. Although VE1 immunostaining and molecular methods used to assess papillary thyroid carcinoma surgical specimens are good agreement, evaluation cytology samples is rarely performed, diagnostic value not well established. In present study, we explored immunoexpression from ex vivo order minimize limitations low cellularity sampling/targeting errors originated...
Purpose: Regional lymph node (LN) metastases are detected in 57-85% of patients with papillary thyroid carcinoma (PTC) and associated increased tumor recurrence.However, the management lymphatic disease PTC has been ongoing source debate.We have prospectively assessed usefulness accuracy sentinel LN (SLN) biopsy for detection on preoperative imaging using single photon emission computed tomography/computed tomography (SPECT/CT) 99mTc phytate.Methods: We 39 who had risk factors recurrence or...
<h3>Background and Objectives</h3> Single-incision transaxillary robotic thyroidectomy (START) requires substantial tissue disruption, which produces moderate-to-severe pain in the axilla neck areas during early postoperative period. This study aimed to investigate analgesic effects of ultrasound-guided serratus-intercostal plane blocks intermediate cervical plexus (CPBs) on after START. <h3>Methods</h3> We randomized 22 patients undergo either CPBs (the block group, n = 11) or not any...
We investigated the risk factors of indeterminate response (IDR) in patients who underwent recombinant human thyroid-stimulating hormone (rhTSH)-aided radioactive iodine therapy (RAIT).A total 128 with papillary thyroid cancer were included this retrospective study. The classified into excellent and IDR groups based on follow-up diagnostic whole-body scintigraphy (WBS) TSH-stimulated thyroglobulin (Tg). Indeterminate was defined as presence a faint uptake bed WBS or Tg detectable, but less...
Abstract The incidence rates of structural persistent disease (PD) and recurrent (RD) after thyroidectomy, their clinicoradiological (CT) characteristics, remain poorly understood. Therefore, we characterized differentiated thyroid cancer (DTC) patients who underwent re-operations, with a focus on preoperative CT scans. We examined neck scans obtained prior to initial surgery reoperation, classified the into four categories according persistence/recurrence dissection/non-dissection status....
Abstract Purpose Recently, high‐precision radiotherapy systems have been developed by integrating computerized tomography or magnetic resonance imaging to enhance the precision of radiotherapy. For integration with additional in a limited space, miniaturization and weight reduction linear accelerator (linac) system become important. The aim this work is develop compact medical linac based on 9.3 GHz X‐band RF technology instead S‐band typically used field. Methods accelerating tube was...