A5101693379- Telomeres, Telomerase, and Senescence
- melanin and skin pigmentation
- Skin Protection and Aging
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- PARP inhibition in cancer therapy
- Liver physiology and pathology
- RNA modifications and cancer
- Immune cells in cancer
- Thyroid Cancer Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Dermatologic Treatments and Research
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Genomics and Diagnostics
- FOXO transcription factor regulation
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Hearing, Cochlea, Tinnitus, Genetics
- TGF-β signaling in diseases
Ajou University
2016-2025
Ajou University Hospital
2024
Chung-Ang University
2022
Konkuk University
2022
National Institute of Food and Drug Safety Evaluation
2017-2018
Keimyung University
2013
Abstract Cellular senescence has been perceived as a barrier against carcinogenesis. However, the senescence-associated secretory phenotype (SASP) of senescent cells can promote tumorigenesis. Here, we show tumour are frequently present in front region collective invasion papillary thyroid carcinoma (PTC), well lymphatic channels and metastatic foci lymph nodes. In vitro analysis, exhibit high ability compared with non-senescent through SASP expression. Collective PTC is led by characterized...
Cutaneous ageing is an important extrinsic process that modifies the pigmentary system.Because cellular senescence a fundamental mechanism, we examined role of senescent cells in pigmentation.Methods: Biopsies obtained from senile lentigo and perilesional normal skin were assayed for marker senescence, p16 INK4A .To determine secretory phenotypes fibroblasts, performed microarray, RNA sequencing methylation array analyses fibroblasts.To further investigate impact on ageing-related...
Abstract Cellular senescence can either support or inhibit cancer progression. Here, it is shown that intratumoral infiltration of CD8 + T cells negatively associated with the proportion senescent tumor in colorectal (CRC). Gene expression analysis reveals increased C‐X‐C motif chemokine ligand 12 (CXCL12) and colony stimulating factor 1 (CSF1) cells. Senescent cell by secreting a high concentration CXCL12, which induces loss CXCR4 result impaired directional migration. CSF1 from enhance...
In this study, we explore the dynamic process of colorectal cancer progression, emphasizing evolution toward a more metastatic phenotype. The term "evolution" as used in study specifically denotes phenotypic transition higher potency from well-formed glandular structures to collective invasion, ultimately resulting development cell buddings at invasive front. Our findings highlight spatial correlation with tumor senescence, revealing distinct types senescent cells (types I and II) that play...
Rationale: Senescent melanocytes accumulate in photoaged skin and are closely related to aging. A better understanding of the molecular characteristics senescent may be key controlling Methods: We have developed an vitro model senescence using UV irradiation investigated functional mechanisms underlying UV-irradiated melanocytes. Results: highlighted that characterized by melanosome transport dysfunction resulting melanin accumulation. The defective was confirmed with ultrastructural...
BACKGROUND O6-methylguanine-DNA methyltransferase (MGMT) can remove O6alkylG DNA adducts. If they are not removed, then the adducts mispair with T during replication, resulting in G-to-A mutation. Interrelations between MGMT gene inactivation by promoter methylation, K-ras mutation, and clinicopathologic features patients gastric carcinoma were studied. METHODS Surgically removed tumor tissues from 79 analyzed methylation genomic modification specific polymerase chain reaction analysis,...
A functional and biochemical interaction of TIS21/BTG2/PC3 with Forkhead box M1 (FoxM1), essential transcription factor for hepatocyte regeneration a master regulator mitotic gene expression, was explored. Growth hepatocellular carcinoma (HCC), developed by single injection diethylnitrosamine (DEN), the same in both TIS21+/+ TIS21−/− mice until 6 months, whereas it significantly higher at 9 months. Expression TIS21 lower human murine HCCs than surrounding tissues. Forced expression impaired...
Abstract It has been proposed that melasma is a photoageing skin disorder. The photoaged fibroblasts have suggested as an important source of melanogenic factors which are involved in the regulation pigmentation. To investigate whether includes senescent cells, lesional and perilesional normal from 38 patients was assessed using cell senescence marker, p16 INK4A . results showed dermal had more ‐positive cells than skin. impact further investigated pilot study radiofrequency ( RF )...
Abstract Ultraviolet (UV)-associated hyperpigmented skins are characterized with increased vasculature underlying pigmentation, suggestive of the possible biological role endothelial cells in regulation skin pigmentation during UV irradiation. In this study, we showed that UV-irradiated significantly melanocytes through epithelial-mesenchymal crosstalk. The stimulatory effect was further demonstrated using ex vivo human skin. RNA sequence analysis and enzyme-linked immunosorbent assay...
Since therapy‐induced senescence (TIS) can either support or inhibit cancer progression, identifying which types of chemotherapeutic agents produce the strongest anti‐tumor TIS is an important issue. Here, cyclin‐dependent kinase4/6 inhibitors (CDK4/6i)‐induced was compared to induced by conventional DNA‐damaging agents. Despite both eliciting a similar degree senescence, we observed increased expression senescence‐associated secretory phenotype (SASP) and ligands related pro‐tumor immunity...
We earlier reported that TIS21 mRNA expression was markedly decreased in A549 and NCIH69 human lung cancer cells thymic carcinoma tissues obtained from transgenic mice containing simian virus 40 large T antigen (J Cancer Res Clin Oncol 121:279–284, 1995). To determine how inhibits growth, we made 293 constitutively expressed protein. The constitutive expresser lines C9 C11 grew to a lower saturation density than did those the vector-transfected clones (V7 V10) antisense-transfected (AS1...
B-RafV600E oncogene mutation occurs most commonly in papillary thyroid carcinoma (PTC) and is associated with tumor initiation.However, a genetic modification by thyrocytes results oncogene-induced senescence (OIS).In the present study, we explored factors involved overcome program PTC.First of all, observed down-regulation p-extracellular signal-regulated kinases 1/2 up-regulation dual specific phosphatase 6 (DUSP6) PTC mutation.DUSP6 overexpression vitro induced extracellular...
B-RafV600E mutant is found in 40–70% of papillary thyroid carcinoma (PTC) and has an important role the pathogenesis PTC. The sodium iodide symporter (NIS) integral plasma membrane glycoprotein that mediates active transport into follicular cells, been known to be associated with loss NIS expression. In this study, we inhibited expression by upregulation its promoter methylation, specific regions CpG islands harboring PTC were highly methylated compared surrounding normal tissue. Although...
Other SectionsABSTRACTINTRODUCTIONIDENTIFICATION OF SENESCENT CELLS IN VIVOSENESCENCE ASSOCIATED SECRETORY PHENOTYPE (SASP) CELLSSENESCENT TUMOR TISSUESCONFLICTS INTERESTFIGUREREFERENCES
Abstract Background: Melanocytes are not simply pigment‐producing cells, but produce substances with a range of biological functions including antimicrobial defense. Recent studies suggest that Toll‐like receptors (TLRs) play an important role in the cellular response through recognition pathogens. Objectives: To investigate whether TLR4 and their adapter molecules expressed human melanocytes. The regulation functional on cell activation were also investigated. Methods: expression...