A5092032527- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- PARP inhibition in cancer therapy
- Retinoids in leukemia and cellular processes
- Chemokine receptors and signaling
- Immune cells in cancer
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Retinal Diseases and Treatments
- Telomeres, Telomerase, and Senescence
Ajou University
2023
Ajou University Hospital
2023
Inha University Hospital
2023
Since therapy‐induced senescence (TIS) can either support or inhibit cancer progression, identifying which types of chemotherapeutic agents produce the strongest anti‐tumor TIS is an important issue. Here, cyclin‐dependent kinase4/6 inhibitors (CDK4/6i)‐induced was compared to induced by conventional DNA‐damaging agents. Despite both eliciting a similar degree senescence, we observed increased expression senescence‐associated secretory phenotype (SASP) and ligands related pro‐tumor immunity...
Diabetic retinopathy (DR) is a disease that causes visual deficiency owing to vascular leakage or abnormal angiogenesis. Pericyte apoptosis considered one of the main in diabetic retina, but there are few known therapeutic agents prevent it. Ulmus davidiana safe natural product has been used traditional medicine and attracting attention as potential treatment for various diseases, its effect on pericyte loss DR not at all. In present study, we investigated effects 60% edible ethanolic...
Cellular senescence is defined as an irreversible cell cycle arrest caused by various internal and external insults. While the metabolic dysfunction of senescent cells in normal tissue relatively well-established, there a lack information regarding features tumor cells.Publicly available single-cell RNA-sequencing data from GSE166555 GSE178341 datasets were utilized to investigate cells. To validate data, we performed senescence-associated β-galactosidase (SA-β-Gal) staining identify fresh...