A5091755573- Hair Growth and Disorders
- Cancer, Hypoxia, and Metabolism
- Phytochemicals and Antioxidant Activities
- Cancer, Lipids, and Metabolism
- Food Quality and Safety Studies
- Growth Hormone and Insulin-like Growth Factors
- Alzheimer's disease research and treatments
- Essential Oils and Antimicrobial Activity
- Genetics and Neurodevelopmental Disorders
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Genomics and Rare Diseases
- Ubiquitin and proteasome pathways
- Skin and Cellular Biology Research
- Dementia and Cognitive Impairment Research
- Wnt/β-catenin signaling in development and cancer
- Cholesterol and Lipid Metabolism
- Diet and metabolism studies
- Connective tissue disorders research
- Lipid metabolism and biosynthesis
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Bioactive Compounds in Plants
- Cancer-related Molecular Pathways
- Postharvest Quality and Shelf Life Management
Yokohama National University
2015-2025
Kanagawa Institute of Technology
2023-2025
Ewha Womans University
2006-2024
Seoul National University
2015-2023
Yonsei University
2022
New Generation University College
2007-2022
Severance Hospital
2022
Fukuda Denshi (Japan)
2022
Myongji University
2016
Duksung Women's University
2011
Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor essential for cancer cell survival. The reprogramming of lipid metabolism has emerged as hallmark cancer, yet the relevance HIF-1α to this process remains elusive. In study, we profile HIF-1α-interacting proteins using proteomics analysis and identify fatty acid-binding protein 5 (FABP5) critical HIF-1α-binding partner. hepatocellular carcinoma (HCC) tissues, both FABP5 are upregulated, their expression levels associated...
Palmitic acid (PA) is the most common fatty in humans and mediates palmitoylation through its conversion into palmitoyl coenzyme A. Although affects many proteins, pathophysiological functions are only partially understood. Here we demonstrate that PA acts as a molecular checkpoint of lipid reprogramming HepG2 Hep3B cells. The zinc finger DHHC-type palmitoyltransferase 23 (ZDHHC23) plant homeodomain protein 2 (PHF2), subsequently enhancing ubiquitin-dependent degradation PHF2. This study...
In vitro models of human hair follicle-like tissue could be fundamental tools to better understand follicle morphogenesis and drug screening. During prenatal development postnatal cyclic regeneration, is triggered by reciprocal interactions the organization epithelial mesenchymal cell populations. Given this mechanism, we developed an approach induce peg-like sprouting in organoid cultures composed cells. Human fetal/adult cells were cultured a medium supplemented with low concentration...
Chilling injury in pepper (Capsicum annuum L.) fruit during cold storage and market distribution results quality loss. In the present study, seed browning, a major chilling symptom, was observed stored at 2 °C, but not 13 °C. To alleviate this we applied vapour treatments of 50 μM methyl jasmonate (MeJA) or 250 salicylate (MeSA), combination both, investigated effect on browning storage. When treated with MeJA, highly inhibited endogenous jasmonic acid (JA) production increased via earlier...
Abstract Nonalcoholic fatty liver disease (NAFLD) is a risk factor for progression of steatohepatitis, cirrhosis, and cancer. Although pathological condition NAFLD, which arises from an excessive accumulation triglyceride in the liver, accompanied by elevated sterol regulatory element-binding protein 1c (SREBP1c) level, it largely unknown factors are involved modification SREBP1c. In this study, we discovered that neddylation SREBP1c competes with its ubiquitination stabilizes eventually...
Abstract Recent multi‐omics analyses paved the way for a comprehensive understanding of pathological processes. However, only few studies have explored Alzheimer’s disease (AD) despite possibility biological subtypes within these patients. For this study, unsupervised classification four datasets (genetics, miRNA transcriptomics, proteomics, and blood‐based biomarkers) using Multi‐Omics Factor Analysis+ (MOFA+), along with systems‐biological approaches following various downstream are...
<h3>Objectives</h3> To clarify the relationships between sleep-wake cycle and cerebral β-amyloid (Aβ) deposition in cognitively normal (CN) older adults, focusing primarily on moderating effects of <i>APOE</i> ε4 allele. <h3>Methods</h3> The present study included 133 CN adults who participated Korean Brain Aging Study for Early Diagnosis & Prediction Alzheimer9s Disease cohort. All participants underwent [<sup>11</sup>C] Pittsburgh compound B-PET imaging to quantify Aβ brain blood...
Abstract Dermal papilla cells (DPCs) play critical roles in hair follicle development, but the underlying mechanisms that contribute to regeneration have yet be fully elucidated, particularly terms of alterations androgenetic alopecia patients. In this study, we demonstrated hypoxia-inducible factor-1α (HIF-1α) is suppressed scalp tissues patients and potentially associated with development. Using RT-qPCR western blot, found mRNA protein levels trichogenic genes, LEF1 versican (VCAN), were...
MOD i ( http://modi.uos.ac.kr/modi/ ) is a powerful and convenient web service that facilitates the interpretation of tandem mass spectra for identifying post-translational modifications (PTMs) in peptide. It it can interpret spectrum even when hundreds modification types are considered number potential PTMs peptide large, contrast to most methods currently available limit PTM sites being used analysis. For example, using , one consider analysis both entire list published on unimod webpage...
Although obesity is a newly considered risk factor for cancer, the mechanisms by which adipocyte-derived metabolites accelerate cancer malignancy have yet to be elucidated. To identify connection among heterogeneous cell types, conventional methods including Transwell assays or conditioned media (CM) been used; however, these do not fully reflect niche effects in tumor microenvironment (TME). Here, we established an oxygen permeable polydimethylsiloxane (PDMS)-based three-dimensional (3D)...
Abstract Oxytocin (OXT) is a neuropeptide hormone termed “love hormone” produced and released during childbirth lactation. It also in response to skin stimulation (e.g., hugging massaging) music therapy. The effects of OXT on various organs have been revealed recent years; however, the relationship between hair follicles remains unclear. In this study, we examined dermal papilla (DP) cells that control growth by secreting growth/regression signals. Gene expression analysis DP signature...
Considerable global demand exists for the development of novel drugs treatment alopecia. A recent report demonstrated that oxytocin promotes hair growth activity in human dermal papilla (DP) cells; however, its application or cosmetic products is challenging because rapid degradation and relatively large molecular weight prevent long-term topical administration on scalp. Here, we examined cinnamic acid, a small molecule activator receptor (OXTR) expression. Treatment with acid led to...
Understanding the underlying mechanisms regulating hair regeneration is crucial, especially given increasing demand for effective drugs to treat loss, which remain not fully elucidated. In present study, we found that lipid metabolism was attenuated in scalp tissues of patients with androgenetic alopecia. Lipid supplementation culture medium upregulated growth-related genes and promoted proliferation human dermal papilla cells (DPCs). By using RNA-sequencing analysis HIF-1α knockdown DPCs, a...
Wiedemann-Steiner syndrome is a rare genetic disorder characterized by short stature, hairy elbows, facial dysmorphism, and developmental delay. It can also be accompanied musculoskeletal anomalies such as muscular hypotonia small hands feet. Mutations in the KMT2A gene have only recently been identified cause of syndrome; therefore, 16 patients from 15 families described, new phenotypic features continue to added. In this report, we describe 2 newly with who presented variable severity. One...
Oxytocin has various effects ranging from promoting labor in pregnant women to alleviating stress. Recently, we reported the hair growth-promoting of oxytocin follicle organoids. However, its clinical application faces challenges such as rapid degradation vivo and poor permeability due large molecular weight. Therefore, this study, investigated receptor (OXTR) agonists WAY267464 LIT001 alternatives on growth. Human dermal papilla (DP) cells were cultured or LIT001-supplemented medium. The...