A5100716898- melanin and skin pigmentation
- Dermatologic Treatments and Research
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Crystallization and Solubility Studies
- Skin Protection and Aging
- Circular RNAs in diseases
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Cancer-related molecular mechanisms research
- Dermatology and Skin Diseases
- MicroRNA in disease regulation
- Genital Health and Disease
- Skin Diseases and Diabetes
- Advancements in Transdermal Drug Delivery
- Genetic and rare skin diseases.
- Food Quality and Safety Studies
- Hidradenitis Suppurativa and Treatments
- Hair Growth and Disorders
- Entomological Studies and Ecology
- Bartonella species infections research
- Face and Expression Recognition
- Inflammatory Myopathies and Dermatomyositis
- interferon and immune responses
- Acne and Rosacea Treatments and Effects
Ajou University Hospital
2023-2024
Ajou University
2014-2023
Korea Advanced Institute of Science and Technology
2022
CHA Bundang Medical Center
2021
CHA University
2021
Kyung Hee University
2019
Lutron Electronics (United States)
2016
Lutronic (South Korea)
2016
Samil Pharm (South Korea)
2010
The differential diagnosis of psoriasis and seborrheic dermatitis can be difficult when both conditions are localized to the scalp without involvement other skin sites.We aimed evaluate histopathological differences between on identify favorable criteria for their diagnosis.We evaluated 15 cases 20 that had been clinicopathologically diagnosed. Skin biopsy sections stained with H&E were examined. Additional immunohistochemistry was performed, including Ki-67, keratin 10, caspase-5, GLUT-1.On...
Rationale: Senescent melanocytes accumulate in photoaged skin and are closely related to aging. A better understanding of the molecular characteristics senescent may be key controlling Methods: We have developed an vitro model senescence using UV irradiation investigated functional mechanisms underlying UV-irradiated melanocytes. Results: highlighted that characterized by melanosome transport dysfunction resulting melanin accumulation. The defective was confirmed with ultrastructural...
Abstract Background Psoriasis is a chronic inflammatory disorder characterized by pathogenic hyperproliferation of keratinocytes and immune dysregulation. Currently, objective evaluation tools reflecting the severity psoriasis are insufficient. MicroRNAs in extracellular vesicles (EV miRNAs) have been shown to be potential biomarkers for various diseases. Our was investigate possibility plasma-derived EV miRNAs as marker disease severity. Methods EVs were extracted from plasma 63 patients...
Psoriasis, a common inflammatory skin disease, is critically dependent on the IL-23/IL-17 cytokine axis. Although immune cell-derived IL-23 generally associated with disease pathogenesis, there have been reports of production in keratinocytes. To determine presence and potential role keratinocyte-derived psoriasis, we investigated its expression levels using publicly available single-cell RNA sequencing data from human samples. We discovered that IL23A was detectable keratinocytes as well...
Dear Editor: Melasma is a common acquired hyperpigmentary disorder of the face, but its treatment remains challenging. A procedure called laser toning that uses low-energy 1064-nm Q-switched Nd:YAG was recently introduced for melasma, demonstrating good results1,2,3. However, possibility mottled hypopigmentation major concern with this treatment, because it rarely recovers spontaneously4. The underlying mechanisms are not completely understood. Whether caused by reduced pigmentation...
Abnormal wound-healing after thyroidectomy with a resulting scar is common dermatologic consultation. Despite many medical and surgical approaches, prevention of postoperative scars challenging.This study validated the efficacy safety low-level light therapy (LLLT) using an 830/590 nm light-emitting diode (LED)-based device for scars.Thirty-five patients linear suture lines were treated LED-LLLT. Daily application 60 J/cm (11 minutes) 1 week starting on day was followed by treatment 3 times...
Introduction Lichen sclerosus et atrophicus (LS) is rare skin condition characterized by the presence of whitish patches primarily affecting genital and perianal areas, though it can occur other parts body. LS may result in depigmentation without textural changes should be differentiated from vitiligo. However, histopathological features hypopigmentation during vitiligo have rarely been compared not precisely described using quantitative immunohistochemical analysis. This study, therefore,...
Abstract is missing (Short communication)
(1) Background: The elevation of glucose metabolism is linked to high-grade gliomas such as glioblastoma multiforme (GBM). high glycolytic phenotype associated with cellular proliferation and resistance treatment chemotherapeutic agents in GBM. MicroRNA-542-3p (miR-542-3p) has been implicated several tumors including gliomas. However, the role miR-542-3p human remains unclear; (2) Methods: We measured levels glioma cells. activity knockdown over-expressed HK2 tissues from patients low- using...
Confluent and reticulated papillomatosis (CRP) is an uncommon dermatosis with a reticular pattern. As differentiation between CRP benign acanthosis nigricans (AN) can be challenging because of their similar clinicopathological features, we aimed to distinguish the two diseases.We retrospectively reviewed clinical characteristics 60 30 AN patients. Histological examinations were conducted on 33 lesions.While was concentrated trunk, mostly appeared in axilla. In group, number obese patients...
Riehl's melanosis is a difficult-to-treat condition characterized by persisting dermal hyperpigmentation. This study aimed to evaluate the efficacy of histology-specific targeted therapy for melanosis.Skin biopsy samples were assessed identify targets treatment. Subsequently, combination involving fractional picosecond laser and pulsed dye (PDL) targeting melanin vessels, respectively, was evaluated. Clinical improvement using pigmentation area severity index (DPASI). The treatment outcomes...
Microbiota is essential to the development and functional maturation of immune system. The effects gut microbiota on myeloid cells remote from gut, especially skin remain unclear. Transcriptomic analysis revealed that type I interferon (IFN) signaling was down-regulated in germ-free mice compared specific pathogen-free mice. decrease IFN closely related presence macrophage-specific marker CD169. absence CD169 + macrophages resulted increased bacterial burden impaired responses against...
Abstract Granulomatous rosacea (GR) is a rare and distinct variant of rosacea. We report three cases recalcitrant GR successfully treated with pulsed‐dye laser (PDL) provide experimental evidence supporting its potential as treatment option. PDL demonstrated remarkable efficacy in the clinical cases, despite their resistance to conventional therapies. Chemokine ligand 9 (CXCL9), key chemokine involved inflammation granuloma formation, was found be increased skin sections from all patients....
Dear Editor: Although surgery is widely accepted as the first-line treatment for extramammary Paget's disease (EMPD), it cannot always be accomplished due to its frequent involvement of areas with important function1. Nonsurgical treatments including radiotherapy (RTx) and photodynamic therapy (PDT) are considered in such cases. We report a case EMPD refractory PDT that was successfully treated RTx. A 68-year-old man presented well-defined erythematous patch ulceration on left side...
One of the most widely used methods for dimensionality reduction is principal component analysis (PCA). However, reduced dimensions from PCA do not provide a clear interpretation with respect to original features because they are linear combinations large number features. This problem can be overcome by feature selection approaches that identifying best subset given In this study, we propose an unsupervised method based on geometrical information loading vectors. Experimental results...