A5071287445- Clinical Nutrition and Gastroenterology
- Fatty Acid Research and Health
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hernia repair and management
- Intestinal and Peritoneal Adhesions
- Neuroblastoma Research and Treatments
- Metabolism and Genetic Disorders
- Childhood Cancer Survivors' Quality of Life
- Tissue Engineering and Regenerative Medicine
- Sarcoma Diagnosis and Treatment
- Eicosanoids and Hypertension Pharmacology
- Congenital Diaphragmatic Hernia Studies
- Palliative Care and End-of-Life Issues
- Cancer, Hypoxia, and Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Renal and related cancers
- Uterine Myomas and Treatments
- Appendicitis Diagnosis and Management
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Abdominal Surgery and Complications
- COVID-19 and healthcare impacts
- Adipose Tissue and Metabolism
University of Wisconsin–Madison
2016-2025
University of Wisconsin American Family Children's Hospital
2020-2025
University of Minnesota
2024
University of Minnesota Medical Center
2024
Ho Chi Minh City Medicine and Pharmacy University
2017
Boston Children's Hospital
2007-2014
Harvard University
2007-2014
Beth Israel Deaconess Medical Center
2011-2014
Center for Vascular Biology Research
2010
Harvard University Press
2009
In Brief Objective: The objective was to determine the safety and efficacy of a fish oil-based intravenous lipid emulsion (ILE) in treatment parenteral nutrition-associated liver disease (PNALD). Summary Background Data: PNALD can be lethal complication children with short bowel syndrome (SBS). ILE based on soybean oil administered nutrition (PN) may contribute its etiology. Methods: We performed an open-labeled trial 42 infants SBS who developed cholestasis (serum direct bilirubin >2 mg/dL)...
Epoxyeicosatrienoic acids (EETs), lipid mediators produced by cytochrome P450 epoxygenases, regulate inflammation, angiogenesis, and vascular tone. Despite pleiotropic effects on cells, the role of these epoxyeicosanoids in normal organ tissue regeneration remains unknown. EETs are predominantly endothelium. Normal require an active paracrine microvascular endothelium, which turn depends angiogenic growth factors. Thus, we hypothesize that endothelial cells stimulate via production bioactive...
The commercial success of tissue engineering products requires efficacy, cost effectiveness, and the possibility scaleup. Advances in require increased sophistication design biomaterials, often challenging current manufacturing techniques. Interestingly, several properties that are desirable for biomaterial embodied structure function plants. This study demonstrates decellularized plant tissues can be used as adaptable scaffolds culture human cells. With simple biofunctionalization...
Women approaching advanced maternal age have extremely poor outcomes with both natural and assisted fertility. Moreover, the incidence of chromosomal abnormalities birth defects increases age. As yet, there is no effective practical strategy for delaying ovarian aging or improving oocyte quality. We demonstrate that lifelong consumption a diet rich in omega-3 fatty acids prolongs murine reproductive function into age, while omega-6 associated very success at Furthermore, even short-term...
The use of fish oil-based emulsions as the sole source fat for patients receiving parenteral nutrition (PN) has raised concerns development essential fatty acid deficiency (EFAD), hindering its adoption into clinical practice. purpose present study was to examine profiles no enteral energy, while completely dependent on PN and an intravenous lipid emulsion, onset EFAD maintenance growth.Prospectively collected data from 10 were reviewed evidence EFAD, defined a triene:tetraene ratio >0.2....
The autologous, synthetic, and animal-derived grafts currently used as scaffolds for tissue replacement have limitations due to low availability, poor biocompatibility, cost. Plant tissues favorable characteristics that make them uniquely suited use scaffolds, such high surface area, excellent water transport retention, interconnected porosity, preexisting vascular networks, a wide range of mechanical properties. Two successful methods plant decellularization engineering applications are...
Background Liver fibrosis is characterized by excessive synthesis of extracellular matrix proteins, which prevails over their enzymatic degradation, primarily metalloproteinases (MMPs). The effect pharmacological MMP inhibition on fibrogenesis, however, largely unexplored. Inflammation considered a prerequisite and important co-contributor to is, in part, mediated tumor necrosis factor (TNF)-α-converting enzyme (TACE). We hypothesized that treatment with broad-spectrum TACE-inhibitor...
Parenteral nutrition (PN)-associated liver disease (PNALD) is a life-threatening complication of the administration PN. The development PNALD may be partly due to composition lipid emulsion administered with PN: soybean oil-based emulsions (SOLE) are associated disease, while fish (FOLE) prevention and improvement disease. objective this study was determine how choice modified production bioactive mediators (LMs). We utilized mouse model steatosis differential effect FOLE SOLE. subsequently...
Abstract Background Image‐guided percutaneous core needle biopsy (PCNB) is increasingly utilized to diagnose solid tumors. The objective of this study determine whether PCNB adequate for modern biologic characterization neuroblastoma. Procedure A multi‐institutional retrospective was performed by the Pediatric Surgical Oncology Research Collaborative on children with neuroblastoma at 12 institutions over a 3‐year period. Data collected included demographics, clinical details, technique,...
ABSTRACT Background Renal medullary carcinoma (RMC) is an aggressive tumor associated with sickle cell trait. Despite treatment advances for other rare renal tumors, RMC survival remains poor. We aimed to describe the contemporary management and of children adults RMC. Procedure In this multicenter retrospective cohort study, Pediatric Surgical Oncology Research Collaborative sites searched their databases patients diagnosed (2000–2022). Descriptive statistics were calculated analyses...
Parenteral nutrition (PN) is a life-saving therapy but has been associated with dyslipidemia. Because fish oil shown to have positive effects on lipid profiles, the authors hypothesize that parenteral emulsion will improve profiles in children who are PN dependent.The examined of unique cohort 10 were exclusively administered oil-based while for median duration 14 weeks. Longitudinal data analysis generalized estimating equations approach was used determine sterol and bilirubin levels based...