A5041058044- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Neonatal Respiratory Health Research
- COVID-19 and healthcare impacts
- Diversity and Career in Medicine
- Hernia repair and management
- Healthcare professionals’ stress and burnout
- Immune Response and Inflammation
- Intestinal Malrotation and Obstruction Disorders
- Trauma and Emergency Care Studies
- Neonatal Health and Biochemistry
- Drug Transport and Resistance Mechanisms
- Innovations in Medical Education
- Hemoglobinopathies and Related Disorders
- Pleural and Pulmonary Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Lymphatic Disorders and Treatments
- Helicobacter pylori-related gastroenterology studies
- Clinical Nutrition and Gastroenterology
- Respiratory Support and Mechanisms
- Gastrointestinal disorders and treatments
- Tracheal and airway disorders
- Urological Disorders and Treatments
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
Michigan Medicine
2017-2025
University of Michigan
2000-2025
C. S. Mott Children's Hospital
2018-2025
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
AstraZeneca (Brazil)
2020
Methicillin-resistant Staphylococcus aureus (MRSA) pneumonia-induced sepsis is a common cause of morbidity in the intensive care unit. Although pneumonia initiated lungs, extrapulmonary manifestations occur commonly. In light key role intestine plays pathophysiology sepsis, we sought to determine whether MRSA induces intestinal injury. FVB/N mice were subjected or sham and killed 24 h later. Septic animals had marked increase epithelial apoptosis by both hematoxylin-eosin active caspase 3...
Whereas most septic patients have an underlying comorbidity, animal models of sepsis use mice that were healthy before the onset infection. Malignancy is common comorbidity associated with sepsis. The purpose this study was to determine whether cancer a different response than animals.Prospective, randomized controlled study.Animal laboratory in university medical center.C57Bl/6 mice.Animals received subcutaneous injection either 250,000 cells transplantable pancreatic adenocarcinoma cell...
Prenatal work-up for congenital diaphragmatic hernia (CDH) is important risk stratification, standardization, counseling, and optimal therapeutic choice. To determine current practice patterns regarding prenatal CDH work-up, including ultrasound magnetic resonance imaging (MRI) use, to identify areas standardization of such evaluation between fetal centers.A survey was sent each member center the North American Fetal Therapy Network (NAFTNet) (n = 36).All responded. Sonographic measurement...
To investigate the prevalence trend of gastroschisis in United States between 2014 and 2022. A cross-sectional retrospective analysis Centers for live births Pregnancies neonatal singleton with documented isolated were included. Neonates other major congenital anomalies known chromosomal abnormalities excluded. Prevalence per 10,000 along 95 % confidence intervals was estimated. Among 32,088,301 births, 6804 cases identified (Point prevalence: 2 births). significant decline observed,...
ABSTRACT Objective To evaluate the variability in magnetic resonance imaging (MRI)‐based parameters used for fetal lung volume estimation prediction of pulmonary hypoplasia and degree liver herniation cases antenatally diagnosed left congenital diaphragmatic hernia (CDH) across North American Fetal Therapy Network (NAFTNet) centers. Methods In this study, 14 NAFTNet radiologists reviewed MRI exams 15 CDH variable severity, eight which had confirmed at surgery. Images were obtained a median...
Mortality in the intensive care unit frequently results from synergistic effect of two temporally distinct infections. This study examined pathophysiology a new model intra-abdominal sepsis followed by methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Mice underwent cecal ligation and puncture (CLP) or sham laparotomy 3 days later an intratracheal injection MRSA saline. Both CLP/saline sham/MRSA mice had 100% survival, whereas animals with CLP pneumonia 67% 7-day survival....