A5063434996- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Congenital gastrointestinal and neural anomalies
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Intestinal Malrotation and Obstruction Disorders
- Inflammatory Bowel Disease
- Esophageal and GI Pathology
- Clinical Nutrition and Gastroenterology
- Digestive system and related health
- Liver Diseases and Immunity
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Global Health and Surgery
- Celiac Disease Research and Management
- Diagnosis and treatment of tuberculosis
- Angiogenesis and VEGF in Cancer
- Gallbladder and Bile Duct Disorders
- Intestinal and Peritoneal Adhesions
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
Oregon Health & Science University
2025
University of Tennessee Health Science Center
2020-2021
Le Bonheur Children's Hospital
2021
Children's Hospital of Los Angeles
2014-2020
Washington University in St. Louis
2015-2018
National Research Institute
2018
University of Southern California
2018
Background Vascular endothelial growth factor (VEGF) is a highly conserved, master regulatory molecule required for cell proliferation, organization, migration and branching morphogenesis. Podocoryne carnea drosophila, which lack cells vascular system, express VEGF homologs, indicating potential roles beyond angiogenesis vasculogenesis. The role of in the development homeostasis postnatal small intestine unknown. We hypothesized regulating bioavailability would exhibit effects vasculature...
ABSTRACT Background Renal medullary carcinoma (RMC) is an aggressive tumor associated with sickle cell trait. Despite treatment advances for other rare renal tumors, RMC survival remains poor. We aimed to describe the contemporary management and of children adults RMC. Procedure In this multicenter retrospective cohort study, Pediatric Surgical Oncology Research Collaborative sites searched their databases patients diagnosed (2000–2022). Descriptive statistics were calculated analyses...
Objective: Data on the incidence of recurrent adhesive small bowel obstruction (ASBO) following index admission for ASBO in children are limited. We sought to determine if operative management was associated with a lower rate recurrence compared non-operative (NOM). Methods: conducted prospective observational study admitted nine hospitals from 10/2020 12/2022 who underwent trial NOM. Children were followed year after admission. The primary outcome readmission ASBO. Adjusted comparisons made...
For patients with short-bowel syndrome, intestinal adaptation is required to achieve enteral independence. Although has been studied extensively in animal models, little known about this process human intestine. We hypothesized that analysis of matched specimens and without luminal flow could identify new potential therapeutic pathways.Fifteen paired ileum samples were collected from children aged 2-20 months during ileostomy-reversal surgery after short-segment resection diversion. The...
338 Background: PF-04136309 (a novel CCR2 inhibitor) has shown anti-tumor activity in the preclinical setting PC by depleting inflammatory monocytes and tumor associated macrophages (TAM) that contribute to an immunosuppressive microenvironment. We hypothesized combining with FOLFIRINOX may improve clinical outcomes PC. Methods: This is a phase Ib study dose de-escalation schema given minimal toxicity of PF-04136309. The includes Arm A (FOLFIRINOX only), B plus PF-04136309) expansion cohort...
Introduction: Splenectomy is common after trauma or hematologic disease, and alters immune protection against pathogens, which may lead to fulminant infection with high mortality. Yet the spleen has demonstrable regenerative capacity cells might be recovered reimplanted at time of injury excision avoid these risks. Methods: Tissue-engineered (TESp) was generated from ActinGFP mice (mTESp) human donor (hTESp) through implantation organoid units (spleen OU), in NOD/SCID concurrent splenectomy,...
New Findings What is the central question of this study? Tissue‐engineered small intestine was previously generated in vivo by immediate implantation organoid units derived from both mouse and human donor intestine. Although transplantation into patients shows promise as a potential future therapy, some critically ill might require delayed transplantation. main finding its importance? Unlike enteroids, which consist isolated intestinal crypts, short‐ long‐term cultured are composed...
Intestinal adaptation (IA) is a critical response to increase epithelial surface area after intestinal loss. Short bowel syndrome (SBS) may follow massive resection in human patients, particularly without adequate IA. We previously validated model zebrafish (ZF) that recapitulates key SBS pathophysiological features. Previous RNA sequencing this identified upregulation of genes the Wnt and Hippo pathways. therefore sought identify timeline increasing cell proliferation considered signaling...
The small intestine has a remarkable ability to enhance its absorptive and digestive surface area through the formation of villi, process known as villification. We sought learn whether developing mouse human tissue-engineered (TESI) followed developmental biology routes villification, such Sonic hedgehog (SHH)/Indian (IHH) bone morphogenetic protein 4 (BMP4)/forkhead box F1 (FOXF1) signaling identify targets development TESI. After generating TESI from prenatal postnatal stem cell sources,...