A5063227298- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Nutrition, Health and Food Behavior
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Cervical Cancer and HPV Research
- Long-Term Effects of COVID-19
- Food Quality and Safety Studies
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Glioma Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- Herpesvirus Infections and Treatments
- Consumer Perception and Purchasing Behavior
- IL-33, ST2, and ILC Pathways
- RNA modifications and cancer
- MicroRNA in disease regulation
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- COVID-19 diagnosis using AI
Jaseng Hospital of Korean Medicine
2024
Korea Advanced Institute of Science and Technology
2014-2024
University Medical Center Groningen
2024
Yale University
2019-2023
University of New Haven
2023
Bayer (Germany)
2023
Hanyang University
2022
Richard L. Roudebush VA Medical Center
2022
Indiana University – Purdue University Indianapolis
2022
Serimmune (United States)
2021
There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more severe symptoms and higher mortality among men than women1–5. However, whether immune responses against acute respiratory syndrome (SARS-CoV-2) differ between sexes, such differences correlate with the sex difference in course of COVID-19, currently unknown. Here we examined viral loads, SARS-CoV-2-specific antibody titres, plasma cytokines blood-cell phenotyping patients moderate COVID-19 who had not...
Nuclear factor erythroid-related 2 (NRF2) encodes a transcription that induces expression of cytoprotective proteins upon oxidative stress and oncogenic NRF2 mutations have been found in lung head/neck cancers inactivate KEAP1-mediated degradation NRF2. The aim this study was to catalogue other human cancers. For this, we analysed 1145 cancer tissues from carcinomas oesophagus, skin, uterine cervix, lung, larynx, breast, colon, stomach, liver, prostate, urinary bladder, ovary, kidney,...
Abstract Rapid and accurate SARS-CoV-2 diagnostic testing is essential for controlling the ongoing COVID-19 pandemic. The current gold standard diagnosis real-time RT-PCR detection of from nasopharyngeal swabs. Low sensitivity, exposure risks to healthcare workers, global shortages swabs personal protective equipment, however, necessitate validation new approaches. Saliva a promising candidate diagnostics because (1) collection minimally invasive can reliably be self-administered (2) saliva...
Abstract Missense somatic mutations in IDH1 gene affecting codon 132 have recently been reported glioblastoma multiforme (GBM) and other gliomas. The recurrent nature of the same amino acid strongly suggests that may play important roles pathogenesis glial tumors. aim this study was to see whether occur human cancers besides We also attempted confirm occurrence GBM Korean patients. analyzed 1,186 cancer tissues from various origins, including carcinomas breast, colon, lung, stomach,...
Abstract The recent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exemplifies the critical need for accurate and rapid diagnostic assays to prompt clinical public health interventions. Currently, several quantitative reverse-transcription polymerase chain reaction (qRT-PCR) are being used by clinical, research, laboratories. However, it is currently unclear if results from different tests comparable. Our goal was evaluate primer-probe sets in four common available on...
Antibodies secreted at the mucosal surface play an integral role in immune defense by serving to neutralize pathogen and promote its elimination site of entry. Secretory immunoglobulin A (IgA) is a predominant Ig isotype surfaces whose epithelial cells express polymeric receptor capable transporting dimeric IgA lumen. Although intestinal mucosa has been extensively studied, cell types responsible for secreting that protects host against pathogens lower respiratory tract are less clear. Here,...
While several clinical and immunological parameters correlate with disease severity mortality in SARS-CoV-2 infection, work remains identifying unifying correlates of coronavirus 2019 (COVID-19) that can be used to guide practice. Here, we examine saliva nasopharyngeal (NP) viral load over time them patient demographics, cellular immune profiling. We found was significantly higher those COVID-19 risk factors; it correlated increasing levels showed a superior ability as predictor (AUC=0.90)....
Abstract Mounting evidence indicates that alterations of autophagy processes are directly involved in the development many human diseases, including cancers. Autophagy‐related gene (ATG) products main players process. In humans there 16 known ATG genes, which four ( ATG2B, ATG5, ATG9B and ATG12 ) have mononucleotide repeats with seven or more nucleotides. Frameshift mutations genes features cancers microsatellite instability (MSI). It is not whether altered by frameshift gastric colorectal...
COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by exaggerated and misdirected host immune responses 1–8 . While pathological innate activation is well documented in severe disease 1 , the impact autoantibodies on progression less defined. Here, we used high-throughput autoantibody discovery technique called Rapid Extracellular Antigen Profiling (REAP) to screen cohort 194 SARS-CoV-2 infected patients healthcare workers for against 2,770 extracellular...
Compared to females, male COVID-19 patients have more kynurenic acid, which may underlie their poorer immune response.
Abstract A growing body of evidence indicates sex differences in the clinical outcomes coronavirus disease 2019 (COVID-19) 1-4 . However, whether immune responses against SARS-CoV-2 differ between sexes, and such explain male susceptibility to COVID-19, is currently unknown. In this study, we examined viral loads, SARS-CoV-2-specific antibody titers, plasma cytokines, as well blood cell phenotyping COVID-19 patients. By focusing our analysis on patients with mild moderate who had not...
Abstract Mounting evidence indicates that deregulation of microRNAs (miRNAs) are involved in development many human diseases, including cancers. Regulation miRNA is a complicated process and some components the regulation known to be altered Among regulation‐related genes, we found AGO1, AGO2, TNRC6A, TNRC6C, TARBP2 EXPORTIN5 genes have mononucleotide repeats their coding sequences. To see whether these mutated cancers with microsatellite instability (MSI), analysed 27 gastric (GCs) high MSI...
Mounting evidence exists that alterations of ubiquitination processes are involved in cancer pathogenesis. Speckle‐type POZ protein ( SPOP ) is a key adaptor for Cul3‐based process. Recent studies reported may be tumor suppressor gene TSG and somatic mutation was detected prostate PCA ). The aim this study to see whether expression features cancers. In study, we analyzed 45 gastric GC ), colorectal CRC by single‐strand conformation polymorphism SSCP Also, 60 , immunohistochemistry. Overall,...
Significance Protective mechanisms of commensal bacteria against viral infection are limited to how immune inductive signals provided by for enhancing immunity. Whether, or how, might influence the effector arm responses remains unknown. Here, we demonstrate that dysbiosis within vaginal microbiota results in severe impairment antiviral protection herpes simplex virus type 2 infection. IL-33 released into tract after antibiotic treatment blocks ability T cells migrate tissue and secrete...
The majority of glioblastomas develop rapidly with a short clinical history (primary glioblastoma IDH wild-type), whereas secondary progress from diffuse astrocytoma or anaplastic astrocytoma. mutations are the genetic hallmark glioblastomas. Gliosarcomas and giant cell rare histological variants, which usually rapidly. We determined patterns 36 gliosarcomas 19 IDH1 IDH2 were absent in all 18 analyzed, indicating that they variants primary glioblastoma. Furthermore, LOH 10q (88%) TERT...