Alice Lu-Culligan
A5049570551- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Reproductive System and Pregnancy
- SARS-CoV-2 detection and testing
- Pregnancy and preeclampsia studies
- COVID-19 diagnosis using AI
- Biosensors and Analytical Detection
- Maternal and fetal healthcare
- Advanced biosensing and bioanalysis techniques
- Parvovirus B19 Infection Studies
- Galectins and Cancer Biology
- Preterm Birth and Chorioamnionitis
- Dental Research and COVID-19
- Gut microbiota and health
- Dermatological and COVID-19 studies
- Cell Image Analysis Techniques
- COVID-19 and Mental Health
- Animal Virus Infections Studies
- Pancreatitis Pathology and Treatment
- Immunodeficiency and Autoimmune Disorders
- Streptococcal Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Omental and Epiploic Conditions
Yale University
2020-2023
There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more severe symptoms and higher mortality among men than women1–5. However, whether immune responses against acute respiratory syndrome (SARS-CoV-2) differ between sexes, such differences correlate with the sex difference in course of COVID-19, currently unknown. Here we examined viral loads, SARS-CoV-2-specific antibody titres, plasma cytokines blood-cell phenotyping patients moderate COVID-19 who had not...
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there no consensus on consequences of CNS infections. Here, we used three independent approaches probe capacity infect brain. First, using human brain organoids, observed clear evidence infection with accompanying metabolic changes in infected and neighboring neurons. However, for type I interferon responses was detected. We...
BACKGROUND. The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case second trimester with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption.
Abstract Rapid and accurate SARS-CoV-2 diagnostic testing is essential for controlling the ongoing COVID-19 pandemic. The current gold standard diagnosis real-time RT-PCR detection of from nasopharyngeal swabs. Low sensitivity, exposure risks to healthcare workers, global shortages swabs personal protective equipment, however, necessitate validation new approaches. Saliva a promising candidate diagnostics because (1) collection minimally invasive can reliably be self-administered (2) saliva...
Summary Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects multiple organ systems including the central nervous system (CNS). Yet, there no consensus whether virus can infect brain, or what consequences of CNS infection are. Here, we used three independent approaches probe capacity brain. First, using human brain organoids, observed clear evidence with accompanying metabolic changes in infected and neighboring neurons. However, for type I interferon...
BackgroundPregnant women are at increased risk for severe outcomes from coronavirus disease 2019 (COVID-19), but the pathophysiology underlying this morbidity and its potential effect on developing fetus is not well understood.MethodsWe assessed placental histology, ACE2 expression, viral immune dynamics term placenta in pregnant with without respiratory acute syndrome 2 (SARS-CoV-2) infection.FindingsThe majority (13 of 15) placentas analyzed had no detectable RNA. was detected by...
Abstract Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that dysbiosis is translocation of bacteria into blood during COVID-19, causing life-threatening secondary infections. We first demonstrate SARS-CoV-2 infection induces mice, which correlated alterations to Paneth cells and goblet cells, markers barrier permeability. Samples collected from 96 patients at two...
Abstract The recent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exemplifies the critical need for accurate and rapid diagnostic assays to prompt clinical public health interventions. Currently, several quantitative reverse-transcription polymerase chain reaction (qRT-PCR) are being used by clinical, research, laboratories. However, it is currently unclear if results from different tests comparable. Our goal was evaluate primer-probe sets in four common available on...
Abstract Background The effects of Covid-19 in pregnancy remain relatively unknown. We present a case second trimester with symptomatic complicated by severe preeclampsia and placental abruption. Methods analyzed placenta for the presence SARS-CoV-2 through molecular immunohistochemical assays electron microscopy, we measured maternal antibody response blood to this infection. Results localized predominantly syncytiotrophoblast cells at maternal-fetal interface placenta. Histological...
Abstract Pregnant women appear to be at increased risk for severe outcomes associated with COVID-19, but the pathophysiology underlying this morbidity and its potential impact on developing fetus is not well understood. In study of pregnant without we assessed viral immune dynamics placenta during maternal SARS-CoV-2 infection. Amongst uninfected women, ACE2 was detected by immunohistochemistry in syncytiotrophoblast cells normal early pregnancy rarely seen healthy placentas full term. Term...
Significance Chilblain diagnoses have increased during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and been attributed to viral infection a subsequent robust antiviral immune response. As result, providers managed these cases differently than idiopathic chilblains, which are associated with cold exposure. The relationship between chilblains SARS-CoV-2 infection, however, remains unclear as most patients do not test positive for SARS-CoV-2–specific PCR or...
The impact of Coronavirus Disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic public interest. We investigated 2 the most widely propagated claims to determine (1) whether COVID-19 mice during early is associated with an increased incidence birth defects or growth abnormalities; (2) mRNA-vaccinated human volunteers exhibit elevated levels antibodies placental protein syncytin-1. Using mouse model, we found that intramuscular at gestational age E7.5...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic imposed a risk of infection and disease in pregnant women neonates. Successful pregnancy requires fine-tuned regulation the maternal immune system to accommodate growing fetus protect mother from infection. Galectins, family β-galactoside–binding proteins, modulate inflammatory processes have been recognized as critical factors reproductive orchestration, including adaptation pregnancy. Pregnancy-specific glycoprotein...
Abstract The impact of coronavirus disease 2019 (COVID-19) mRNA vaccination on pregnancy and fertility has become a major topic public interest. We investigated two the most widely propagated claims to determine 1) whether COVID-19 mice during early is associated with an increased incidence birth defects or growth abnormalities, 2) mRNA-vaccinated human volunteers exhibit elevated levels antibodies placental protein syncytin-1. Using mouse model, we found that intramuscular at gestational...