Mericien Venzon
A5053604918- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Clostridium difficile and Clostridium perfringens research
- Parasite Biology and Host Interactions
- SARS-CoV-2 and COVID-19 Research
- Genetics, Aging, and Longevity in Model Organisms
- Long-Term Effects of COVID-19
- Parasites and Host Interactions
- Tryptophan and brain disorders
- Diet and metabolism studies
- Helminth infection and control
- Circadian rhythm and melatonin
- Inflammatory Bowel Disease
- Neuroendocrine regulation and behavior
- Amphibian and Reptile Biology
- Viral gastroenteritis research and epidemiology
- Immune responses and vaccinations
- Vector-borne infectious diseases
- Venomous Animal Envenomation and Studies
- Immune Cell Function and Interaction
New York University
2019-2024
OncoMed (United States)
2021
AbbVie (United States)
2021
Janssen (Belgium)
2021
Ferring Pharmaceuticals (Switzerland)
2021
Allergan (France)
2021
Takeda (France)
2021
Arena Pharmaceuticals (United States)
2021
Eli Lilly (United States)
2021
Ferring Pharmaceuticals (France)
2021
Abstract Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that dysbiosis is translocation of bacteria into blood during COVID-19, causing life-threatening secondary infections. We first demonstrate SARS-CoV-2 infection induces mice, which correlated alterations to Paneth cells and goblet cells, markers barrier permeability. Samples collected from 96 patients at two...
<title>Abstract</title> The microbial populations in the gut microbiome have recently been associated with COVID-19 disease severity. However, a causal impact of on patient health has not established. Here we provide evidence that dysbiosis is translocation bacteria into blood during COVID-19, causing life-threatening secondary infections. Antibiotics and other treatments can potentially confound associations. We therefore first demonstrate directly affected by SARS-CoV-2 infection...
The bacterial microbiota promotes the life cycle of intestine-dwelling whipworm Trichuris by mediating hatching parasite eggs ingested mammalian host. Despite enormous disease burden associated with colonization, mechanisms underlying this transkingdom interaction have been obscure. Here, we used a multiscale microscopy approach to define structural events bacteria-mediated for murine model muris . Through combination scanning electron (SEM) and serial block face SEM (SBFSEM), visualized...
The microbial populations in the gut microbiome have recently been associated with COVID-19 disease severity. However, a causal impact of on patient health has not established. Here we provide evidence that dysbiosis is translocation bacteria into blood during COVID-19, causing life-threatening secondary infections. Antibiotics and other treatments can potentially confound associations. We therefore first demonstrate mouse model SARS-CoV-2 infection induce dysbiosis, which correlated...
The bacterial microbiota promotes the life cycle of intestine-dwelling whipworm
Abstract Background Beyond systematic reviews and meta-analyses, there have been no direct studies of serological response to COVID-19 in patients with inflammatory bowel disease (IBD) across continents. In particular, has limited data from Asia, reported India. The ICARUS-IBD (International study Antibody Response Under Sustained immunosuppression IBD) consortium assessed SARS-CoV-2 IBD North America, Europe, Asia. Methods is a multicenter observational cohort spanning sites 7 countries. We...
Summary A distinguishing feature of Trichuris nematodes is that these parasitic worms reproduce within the digestive tracts humans and other mammalian hosts shedding thousands eggs daily, facilitating their sustained presence in environment hampering eradication efforts. Although this aspect lifecycle places a microbiota-rich environment, metabolic byproducts bacteria facilitate reproductive development parasites are unknown. Here, we employ pipeline using well-characterized free-living...
Abstract While differential antibody responses SARS-CoV-2 in patients with inflammatory bowel disease (IBD) receiving infliximab and vedolizumab are well-characterized, the immune pathways underlying these differences remain unknown. Prior to COVID-19 vaccine development, we screened 235 IBD biological therapy for antibodies measured serum cytokines. In seropositive patients, prospectively collected clinical data. We found a cytokine signature who compared seronegative that may be linked...
Trichuris nematodes reproduce within the microbiota-rich mammalian intestine and shed thousands of eggs daily, facilitating their sustained presence in environment hampering eradication efforts. However, microbial byproducts that facilitate reproductive development this parasitic worm remain unknown. Here, we report a pipeline to identify factors with conserved roles reproduction nematodes. A screen for E. coli mutants impair C. elegans fertility identified genes fatty acid biosynthesis...