A5014686555- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Prenatal Screening and Diagnostics
- COVID-19 Impact on Reproduction
- Gestational Diabetes Research and Management
- Ectopic Pregnancy Diagnosis and Management
- Preterm Birth and Chorioamnionitis
- Cardiovascular Issues in Pregnancy
- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
- SARS-CoV-2 and COVID-19 Research
- Congenital Heart Disease Studies
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Child and Adolescent Psychosocial and Emotional Development
- Maternal and fetal healthcare
- Immune responses and vaccinations
- Maternal and Perinatal Health Interventions
- Infant Nutrition and Health
- Vaccine Coverage and Hesitancy
- Attachment and Relationship Dynamics
- Pediatric Urology and Nephrology Studies
Universität Hamburg
2016-2025
University Medical Center Hamburg-Eppendorf
2016-2025
Yale University
2023
Klinik und Poliklinik für Kinder- und Jugendmedizin
2018
Queen Charlotte's and Chelsea Hospital
2018
Imperial College London
2015
KU Leuven
2015
Institute for Reproductive Health
2015
University College London
2015
Emma Kinderziekenhuis
2015
Background Perinatal mortality and morbidity continue to be major global health challenges strongly associated with prematurity reduced fetal growth, an issue of further interest given the mounting evidence that growth in general is linked degrees risk common noncommunicable diseases adulthood. Against this background, WHO made it a high priority provide present charts for estimated weight (EFW) ultrasound biometric measurements intended worldwide use. Methods Findings We conducted...
ABSTRACT Objectives Few data exist for counseling and perinatal management of women after an antenatal diagnosis early‐onset fetal growth restriction. Yet, the consequences preterm delivery its attendant morbidity both mother baby are far reaching. The objective this study was to describe mortality following restriction based on time delivery. Methods We report cohort outcomes a prospective multicenter randomized (Trial Randomized Umbilical Fetal Flow in Europe ( TRUFFLE )) performed 20...
The aim of our study was to examine maternal weight gain as well nutrient intake in pregnancy throughout each trimester compared current recommendations a low-risk population and its correlation birth weight. Additionally, we have investigated the association nutrition with gestational an economically unrestricted population.Our analysis carried out population-based prospective cohort Hamburg, Germany. 200 pregnant women 197 infants born at term were included analysis. Maternal body weight,...
During mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric (MMc) in the offspring is mostly unknown. Here we show a mouse model which MMc numbers either normal or low, enables assessment MMc. We report promoting fetal development. induces preferential differentiation hematopoietic stem bone marrow towards monocytes within myeloid compartment. Neonatal mice with higher and enhanced resilience against...
Climate change, in particular the exposure to heat, impacts on human health and can trigger diseases. Pregnant people are considered a vulnerable group given physiological changes during pregnancy potentially long-lasting consequences for offspring. Evidence published date higher risk of complications upon heat stress from geographical areas with high ambient temperatures. Studies geographic regions temperate climates sparse; however, these critical since individuals may be less equipped...
ABSTRACT Objective To assess foetal circulating free haemoglobin (fHbF) levels and heme defences, correlated to circulatory biometry sex in severe early‐onset growth restriction (FGR). Design, Setting Population A prospective study pregnancies with close clinical management (estimated weight (EFW) < 3rd centile 600 g at 20–26 + 6 weeks; N = 20). Method & Main Outcome Measures Temporal vascular obstetric was recorded. Cord blood fHbF key heme‐scavenger defences were measured compared...
Fetal growth restriction (FGR) is a serious obstetric condition for which there currently no treatment. The EVERREST Prospective Study has been designed to characterise the natural history of pregnancies affected by severe early onset FGR and establish well phenotyped bio-bank. findings will provide up-to-date information clinicians patients inform design conduct Clinical Trial: phase I/IIa trial assess safety efficacy maternal vascular endothelial factor (VEGF) gene therapy in FGR. Data...
Neonatal passive immunity, derived from transplacental transfer of IgG antibodies mother to fetus during pregnancy, can mitigate the risk for severe infections in early postnatal period. Understanding placenta as gateway organ this process, we aimed evaluate influence specific factors modulating rate (TPTR) 141 mother/neonate pairs. We further evaluated potential health advantage elicited by maternal with regard respiratory tract infancy and childhood. Data biological samples collected...
In the recent TRUFFLE study, it appeared that, in pregnancies complicated by fetal growth restriction (FGR) between 26 and 32 weeks' gestation, monitoring of ductus venosus (DV) waveform combined with computed cardiotocography (CTG) to determine timing delivery increased chance infant survival without neurological impairment. However, concerns interpretation were raised, as DV be associated a non-significant increase death, some infants delivered after weeks, at which time study protocol no...
ABSTRACT Objective To report the outcome of monochorionic twins with twin reversed arterial perfusion (TRAP) sequence following interstitial laser therapy in first trimester. Methods This was a retrospective cohort study all consecutive cases TRAP that underwent at ≤ 14 + 3 weeks' gestation between January 2014 and April 2016. Interstitial treatment performed under ultrasound guidance using 400‐nm Nd:YAG fiber. Hospital records were reviewed to ascertain perinatal survival morbidity. Results...
Fetal growth restriction (FGR) is the most common pregnancy complication in developed countries. Pregnancies affected by FGR, frequently concur with complications and high risk of neonatal morbidity mortality. To date, no approved treatment available for pregnant women FGR. The objective this study was to investigate contribution galectin-3 (gal-3), a β-galactoside binding protein involved pregnancy, placental function fetal growth. We demonstrated that lack gal-3 during mouse leads...
To explore whether, in early fetal growth restriction (FGR), the longitudinal pattern of heart rate (FHR) short-term variation (STV) can be used to identify imminent distress and whether abnormalities FHR recordings are associated with 2-year infant outcome.The original TRUFFLE study assessed FGR, delivery based on ductus venosus (DV) Doppler pulsatility index (PI), combination safety-net criteria very low STV cardiotocography (CTG) and/or recurrent decelerations, could improve survival...