A5101708477- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Atrial Fibrillation Management and Outcomes
- Cancer-related Molecular Pathways
- Cardiac electrophysiology and arrhythmias
- Acute Myeloid Leukemia Research
- Genomics, phytochemicals, and oxidative stress
- Cardiac Arrhythmias and Treatments
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Advanced MRI Techniques and Applications
- RNA Research and Splicing
- Cardiac pacing and defibrillation studies
- Glutathione Transferases and Polymorphisms
- Cell death mechanisms and regulation
- Microtubule and mitosis dynamics
- Glioma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Human Health and Disease
- Polar Research and Ecology
CHA Bundang Medical Center
2025
CHA University
2025
Dongguk University Ilsan Hospital
2022
Catholic University of Korea
2008-2019
Incheon St. Mary's Hospital
2015-2019
Seoul St. Mary's Hospital
2015
Asan Medical Center
2014-2015
University of Ulsan
2015
Ulsan College
2015
Gachon University
2015
Nuclear factor erythroid-related 2 (NRF2) encodes a transcription that induces expression of cytoprotective proteins upon oxidative stress and oncogenic NRF2 mutations have been found in lung head/neck cancers inactivate KEAP1-mediated degradation NRF2. The aim this study was to catalogue other human cancers. For this, we analysed 1145 cancer tissues from carcinomas oesophagus, skin, uterine cervix, lung, larynx, breast, colon, stomach, liver, prostate, urinary bladder, ovary, kidney,...
Abstract Missense somatic mutations in IDH1 gene affecting codon 132 have recently been reported glioblastoma multiforme (GBM) and other gliomas. The recurrent nature of the same amino acid strongly suggests that may play important roles pathogenesis glial tumors. aim this study was to see whether occur human cancers besides We also attempted confirm occurrence GBM Korean patients. analyzed 1,186 cancer tissues from various origins, including carcinomas breast, colon, lung, stomach,...
Yoo N J, Kim H R, Y An C & Lee S (2012) Histopathology 60, 943–952 Somatic mutations of the KEAP1 gene in common solid cancers Aims: inhibits nuclear factor erythroid 2‐related 2 (NRF2)‐induced cytoprotection, and is considered to be a candidate tumour suppressor. mutation NRF2 has been analysed wide variety human cancers, whereas somatic reported only lung gall bladder cancers. The aim our study was investigate whether are widespread Methods results: We 499 cancer tissues from lung,...
Abstract Mounting evidence indicates that alterations of autophagy processes are directly involved in the development many human diseases, including cancers. Autophagy‐related gene (ATG) products main players process. In humans there 16 known ATG genes, which four ( ATG2B, ATG5, ATG9B and ATG12 ) have mononucleotide repeats with seven or more nucleotides. Frameshift mutations genes features cancers microsatellite instability (MSI). It is not whether altered by frameshift gastric colorectal...
Early recurrence (ER) of atrial tachyarrhythmias during the first 3 months (blanking period) after fibrillation ablation can be highly symptomatic, often requiring emergency treatment. Short-term steroid therapy may suppress ER blanking period.We prospectively enrolled 138 patients who were randomly assigned to 2 groups (steroid group and control group). An intravenous bolus 0.5 mg/kg methylprednisolone for days followed by 12 mg daily oral 4 was given patients. The primary end point period...
IgG4-related disease (IgG4-RD) is an autoimmune condition marked by IgG4-positive plasma cell infiltration, causing inflammation, fibrosis, and tumor-like lesions, especially in the lacrimal gland (LG). Current diagnostic criteria, based primarily on serum IgG4 levels, face limitations predicting clinical outcomes treatment responses. To address this, we conducted a multiplex immaunohistochemical analysis of LG tissues to assess immune checkpoint interactions distribution relation mass size,...
Activation of nuclear factor-kappa B (NF-kappaB) signaling is considered an important mechanism in the development prostate cancers. A recent study revealed that IkappaB kinase epsilon (IKKepsilon), activator NF-kappaB, was overexpressed breast cancers and acted as oncogene. Expression NF-kappaB members has been reported cancer tissues, but expression IKKepsilon not yet studied In this study, we attempted to explore whether expressions p50/105, p52/p100 RelA are altered We analyzed...
Introduction. Somatic mutations in plant homeodomain finger protein 6 (PHF6) gene have recently been reported T-cell acute lymphoblastic leukemia (T-ALL), strongly suggesting its role the pathogenesis of human cancers. Materials and methods. To see whether PHF6 mutation occurs other malignancies, we analyzed entire coding sequences 231 hematologic malignancies [105 myelogenous leukemias (AML), 66 pre-B-ALL, 23 T-ALL, one undifferentiated 36 multiple myelomas] by single-strand conformation...
Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs) form a protein complex with aminoacyl-tRNA synthetases. In addition to translation, AIMPs play role in diverse biological processes. Earlier studies suggested that may act as tumor suppressors. However, the expression status of AIMP human cancer tissues is largely unknown. this study, we analyzed members (AIMP1, AIMP2 and AIMP3) gastric (GC) colorectal (CRC) tissues. We these 100 GC 103 CRC by immunohistochemistry using...
Aminoacyl -tRNA synthetase -interacting multifunctional proteins (AIMPs) form a protein complex with aminoacyl synthetases. In addition to transla tion, AIMPs play role in diverse biological processes. Earlier studies suggested that may act as tumor suppressors. However, the expression status of AIMP human cancer tissues is largely unknown. this study, we analyzed members (AIMP1, AIMP2 and AIMP3) gastric (GC) colorectal (CRC) . We these 100 GC 103CRC by immunohistochemistry using atissue...
Purpose The TTK gene plays a crucial role in regulation of the mitotic checkpoint. has an A9 mononucleotide repeat coding sequences, which harbors mutations gastric (GC) and colorectal cancers (CRC) with microsatellite instability (MSI). However, there are three more repeats (the A7s) sequences that have not been analyzed. aim this study was to explore whether A7s as well altered GC CRC, find any association mutation clinocopathologic characteristics CRC. Materials Methods We analyzed exon 5...
<h3>Objective</h3> Hypothermia can induce ECG J waves. Recent studies suggest that waves may be associated with ventricular fibrillation (VF) in patients structurally normal hearts. However, little is known about the features, clinical significance or arrhythmogenic potentials of therapeutic hypothermia (TH)-induced <h3>Methods</h3> We analysed ECGs from 240 who underwent TH at six major university hospitals Korea between August 2010 and December 2013. The prevalence, amplitudes...
Medtronic CapSureFix MRI 5086 pacing lead (5086; Medtronic, Inc. ,
The use of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with non-valvular atrial fibrillation (AF) has been increasing. Accordingly, the combined antiplatelet agents (APT) and NOAC therapy is commonly encountered clinical practice. purpose this study was to compare outcomes between combination (NOAC APT) vs. monotherapy only) AF.We retrospectively analyzed who were prescribed NOACs January 2012 December 2016. primary outcome major bleeding any events, secondary...